Araştırma Makalesi
BibTex RIS Kaynak Göster

Protective role of sildenafil citrate in isoniazid-rifampicin induced histomorphological changes in liver of albino mice

Yıl 2021, Cilt: 15 Sayı: 1, 52 - 58, 29.04.2021

Öz

Objectives: The objective of the study was to reveal the reversal of histo-morphological changes in mice liver induced by combined isoniazid-rifampicin (INH-RIF) therapy with sildenafil treatment.
Methods: Twenty-one mice weighing between 25–35 g were enrolled in the study. Randomisation was carried out by simple balloting method. The selected mice were sorted into three groups with 7 mice, each group. In group C (n=7) control group, mice were administered 0.4ml of saline per kg body weight daily intra peritoneally for 21 days. In group R (n=7) INH-RIF group, rifampicin (50 mg/kg) and isoniazid (50 mg/kg), dissolved in 4 ml/kg isotonic saline, were administered intra-peritoneally (ip) daily for 21 days. In group S (n=7) sildenafil administered group, 10 mg/kg sildenafil was given orally by gastric gavage on daily basis along with the intraperitoneal injection of INH-RIF (50 mg/kg each) daily for 21 days.
Results: Histopathology revealed hepatotoxicity in group R (INH-RIF), while significant improvement was observed in group C (INH-RIF-sildenafil).
Conclusion: Sildenafil citrate possesses hepatoprotective role against INH-RIF induced hepatotoxicity.

Destekleyen Kurum

nil

Proje Numarası

nil

Teşekkür

thanks

Kaynakça

  • Laghari M, Sulaiman SA, Khan AH, Memon N. Epidemiology of tuberculosis and treatment outcomes among children in Pakistan: a 5-year retrospective study. PeerJ 2018;6:e5253.
  • D'Ambrosio L, Dara M, Tadolini M, Centis R, Sotgiu G, Van Der Werf MJ, Gaga M, Cirillo D, Spanevello A, Raviglione M, Blasi F. Tuberculosis elimination: theory and practice in Europe. Eur Respir J 2014;43:1410–20.
  • Pan Y, Cao M, You D, Qin G, Liu Z. Research progress on the animal models of drug-induced liver injury: current status and further perspectives. Biomed Res Int 2019;2019:1283824
  • Humayun F, Tahir M, Lone KP. Histological effects of isoniazid on the liver of albino mice. Khyber Medical University Journal 2017;30:85–91.
  • Schaberg T, Rebhan K, Lode H. Risk factors for side-effects of isoniazid, rifampin and pyrazinamide in patients hospitalized for pulmonary tuberculosis. Eur Respir J 1996;9:2026–30.
  • Ramappa V, Aithal GP. Hepatotoxicity related to anti-tuberculosis drugs: mechanisms and management. J Clin Exp Hepatol 2013;3: 37–49.
  • Čustović S, Muzika V, Mornjaković Z, Ćosović E, Kapić D. Qualitative histological study of isoniazid-rifampicin induced liver injury in rats. Folia Medica Facultatis Medicinae Universitatis Saraeviensis 2015;50:2.
  • Sodhi CP, Rana SV, Mehta SK, Vaiphei K, Attari S, Mehta S. Study of oxidative-stress in isoniazid-rifampicin induced hepatic injury in young rats. Drug Chem Toxicol 1997;20:255–69.
  • Bigoniya P, Singh CS, Shukla A. A comprehensive review of different liver toxicants used in experimental pharmacology. International Journal of Pharmaceutical Sciences and Drug Research 2009;1:124–35.
  • Hatzimouratidis K. Sildenafil in the treatment of erectile dysfunction: an overview of the clinical evidence. Clin Interv Aging 2006;1: 403–14.
  • Sheweita S, Salama B, Hassan M. Erectile dysfunction drugs and oxidative stress in the liver of male rats. Toxicol Rep 2015;2:933–8.
  • Said E, Said SA, Gameil NM, Ammar EM. Modulation of thioacetamide-induced liver fibrosis/cirrhosis by sildenafil treatment. Can J Physiol Pharmacol 2013;91:1055–63.
  • Ekor M, Odewabi AO, Kale OE, Bamidele TO, Adesanoye OA, Farombi EO. Modulation of paracetamol-induced hepatotoxicity by phosphodiesterase isozyme inhibition in rats: a preliminary study. J Basic Clin Physiol Pharmacol 2013;24:73–9.
  • Rizk AA, Shawky YM, Motawie AG. Can sildenafil citrate ameliorate cisplatin-induced nephrotoxicity? Crosstalk between the possible mechanisms. Eur J Anat 2019;23:113–9.
  • Vitaglione P, Morisco F, Caporaso N, Fogliano V. Dietary antioxidant compounds and liver health. Crit Rev Food Sci Nutr 2005;44: 575–86.
  • Alía M, Horcajo C, Bravo L, Goya L. Effect of grape antioxidant dietary fiber on the total antioxidant capacity and the activity of liver antioxidant enzymes in rats. Nutrition Research 2003;23: 1251–67.
  • Pal R, Vaiphei K, Arbab Sikander KS, Rana SV. Effect of garlic on isoniazid and rifampicin-induced hepatic injury in rats. World J Gastroenterol 2006;12:636–9.
  • Pal R, Rana S, Vaiphei K, Singh K. Effect of different doses of carotenoids in isoniazid-rifampicin induced hepatotoxicity in rats. Trop Gastroenterol 2010;29:153–9.
  • Wang C, Fan RQ, Zhang YX, Nie H, Li K. Naringenin protects against isoniazid-and rifampicin-induced apoptosis in hepatic injury. World J Gastroenterol 2016;22:9775–83.
  • Yang Y, Jiang L, Wang S, Zeng T, Xie K. Diallyl trisulfide protects the liver against hepatotoxicity induced by isoniazid and rifampin in mice by reducing oxidative stress and activating Kupffer cells. Toxicol Res 2016;5:954–62.
  • Li S, Tan HY, Wang N, Zhang ZJ, Lao L, Wong CW, Feng Y. The role of oxidative stress and antioxidants in liver diseases. Int J Mol Sci 2015;16:26087–124.
  • Adhvaryu MR, Reddy NM, Vakharia BC. Prevention of hepatotoxicity due to anti tuberculosis treatment: a novel integrative approach. World J Gastroenterol 2008;14:4753–62.
  • Tetsi L, Charles AL, Georg I, Goupilleau F, Lejay A, Talha S, Maumy-Bertrand M, Lugnier C, Geny B. Effect of the phosphodiesterase 5 inhibitor sildenafil on ischemia-reperfusion-induced muscle mitochondrial dysfunction and oxidative stress. Antioxidants (Basel) 2019;8:93.
Yıl 2021, Cilt: 15 Sayı: 1, 52 - 58, 29.04.2021

Öz

Proje Numarası

nil

Kaynakça

  • Laghari M, Sulaiman SA, Khan AH, Memon N. Epidemiology of tuberculosis and treatment outcomes among children in Pakistan: a 5-year retrospective study. PeerJ 2018;6:e5253.
  • D'Ambrosio L, Dara M, Tadolini M, Centis R, Sotgiu G, Van Der Werf MJ, Gaga M, Cirillo D, Spanevello A, Raviglione M, Blasi F. Tuberculosis elimination: theory and practice in Europe. Eur Respir J 2014;43:1410–20.
  • Pan Y, Cao M, You D, Qin G, Liu Z. Research progress on the animal models of drug-induced liver injury: current status and further perspectives. Biomed Res Int 2019;2019:1283824
  • Humayun F, Tahir M, Lone KP. Histological effects of isoniazid on the liver of albino mice. Khyber Medical University Journal 2017;30:85–91.
  • Schaberg T, Rebhan K, Lode H. Risk factors for side-effects of isoniazid, rifampin and pyrazinamide in patients hospitalized for pulmonary tuberculosis. Eur Respir J 1996;9:2026–30.
  • Ramappa V, Aithal GP. Hepatotoxicity related to anti-tuberculosis drugs: mechanisms and management. J Clin Exp Hepatol 2013;3: 37–49.
  • Čustović S, Muzika V, Mornjaković Z, Ćosović E, Kapić D. Qualitative histological study of isoniazid-rifampicin induced liver injury in rats. Folia Medica Facultatis Medicinae Universitatis Saraeviensis 2015;50:2.
  • Sodhi CP, Rana SV, Mehta SK, Vaiphei K, Attari S, Mehta S. Study of oxidative-stress in isoniazid-rifampicin induced hepatic injury in young rats. Drug Chem Toxicol 1997;20:255–69.
  • Bigoniya P, Singh CS, Shukla A. A comprehensive review of different liver toxicants used in experimental pharmacology. International Journal of Pharmaceutical Sciences and Drug Research 2009;1:124–35.
  • Hatzimouratidis K. Sildenafil in the treatment of erectile dysfunction: an overview of the clinical evidence. Clin Interv Aging 2006;1: 403–14.
  • Sheweita S, Salama B, Hassan M. Erectile dysfunction drugs and oxidative stress in the liver of male rats. Toxicol Rep 2015;2:933–8.
  • Said E, Said SA, Gameil NM, Ammar EM. Modulation of thioacetamide-induced liver fibrosis/cirrhosis by sildenafil treatment. Can J Physiol Pharmacol 2013;91:1055–63.
  • Ekor M, Odewabi AO, Kale OE, Bamidele TO, Adesanoye OA, Farombi EO. Modulation of paracetamol-induced hepatotoxicity by phosphodiesterase isozyme inhibition in rats: a preliminary study. J Basic Clin Physiol Pharmacol 2013;24:73–9.
  • Rizk AA, Shawky YM, Motawie AG. Can sildenafil citrate ameliorate cisplatin-induced nephrotoxicity? Crosstalk between the possible mechanisms. Eur J Anat 2019;23:113–9.
  • Vitaglione P, Morisco F, Caporaso N, Fogliano V. Dietary antioxidant compounds and liver health. Crit Rev Food Sci Nutr 2005;44: 575–86.
  • Alía M, Horcajo C, Bravo L, Goya L. Effect of grape antioxidant dietary fiber on the total antioxidant capacity and the activity of liver antioxidant enzymes in rats. Nutrition Research 2003;23: 1251–67.
  • Pal R, Vaiphei K, Arbab Sikander KS, Rana SV. Effect of garlic on isoniazid and rifampicin-induced hepatic injury in rats. World J Gastroenterol 2006;12:636–9.
  • Pal R, Rana S, Vaiphei K, Singh K. Effect of different doses of carotenoids in isoniazid-rifampicin induced hepatotoxicity in rats. Trop Gastroenterol 2010;29:153–9.
  • Wang C, Fan RQ, Zhang YX, Nie H, Li K. Naringenin protects against isoniazid-and rifampicin-induced apoptosis in hepatic injury. World J Gastroenterol 2016;22:9775–83.
  • Yang Y, Jiang L, Wang S, Zeng T, Xie K. Diallyl trisulfide protects the liver against hepatotoxicity induced by isoniazid and rifampin in mice by reducing oxidative stress and activating Kupffer cells. Toxicol Res 2016;5:954–62.
  • Li S, Tan HY, Wang N, Zhang ZJ, Lao L, Wong CW, Feng Y. The role of oxidative stress and antioxidants in liver diseases. Int J Mol Sci 2015;16:26087–124.
  • Adhvaryu MR, Reddy NM, Vakharia BC. Prevention of hepatotoxicity due to anti tuberculosis treatment: a novel integrative approach. World J Gastroenterol 2008;14:4753–62.
  • Tetsi L, Charles AL, Georg I, Goupilleau F, Lejay A, Talha S, Maumy-Bertrand M, Lugnier C, Geny B. Effect of the phosphodiesterase 5 inhibitor sildenafil on ischemia-reperfusion-induced muscle mitochondrial dysfunction and oxidative stress. Antioxidants (Basel) 2019;8:93.
Toplam 23 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Original Articles
Yazarlar

Najma Hameed 0000-0003-2537-1759

Khalid Sadozai Bu kişi benim 0000-0003-1985-0235

Proje Numarası nil
Yayımlanma Tarihi 29 Nisan 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 15 Sayı: 1

Kaynak Göster

APA Hameed, N., & Sadozai, K. (2021). Protective role of sildenafil citrate in isoniazid-rifampicin induced histomorphological changes in liver of albino mice. Anatomy, 15(1), 52-58.
AMA Hameed N, Sadozai K. Protective role of sildenafil citrate in isoniazid-rifampicin induced histomorphological changes in liver of albino mice. Anatomy. Nisan 2021;15(1):52-58.
Chicago Hameed, Najma, ve Khalid Sadozai. “Protective Role of Sildenafil Citrate in Isoniazid-Rifampicin Induced Histomorphological Changes in Liver of Albino Mice”. Anatomy 15, sy. 1 (Nisan 2021): 52-58.
EndNote Hameed N, Sadozai K (01 Nisan 2021) Protective role of sildenafil citrate in isoniazid-rifampicin induced histomorphological changes in liver of albino mice. Anatomy 15 1 52–58.
IEEE N. Hameed ve K. Sadozai, “Protective role of sildenafil citrate in isoniazid-rifampicin induced histomorphological changes in liver of albino mice”, Anatomy, c. 15, sy. 1, ss. 52–58, 2021.
ISNAD Hameed, Najma - Sadozai, Khalid. “Protective Role of Sildenafil Citrate in Isoniazid-Rifampicin Induced Histomorphological Changes in Liver of Albino Mice”. Anatomy 15/1 (Nisan 2021), 52-58.
JAMA Hameed N, Sadozai K. Protective role of sildenafil citrate in isoniazid-rifampicin induced histomorphological changes in liver of albino mice. Anatomy. 2021;15:52–58.
MLA Hameed, Najma ve Khalid Sadozai. “Protective Role of Sildenafil Citrate in Isoniazid-Rifampicin Induced Histomorphological Changes in Liver of Albino Mice”. Anatomy, c. 15, sy. 1, 2021, ss. 52-58.
Vancouver Hameed N, Sadozai K. Protective role of sildenafil citrate in isoniazid-rifampicin induced histomorphological changes in liver of albino mice. Anatomy. 2021;15(1):52-8.

Anatomy is the official publication of the Turkish Society of Anatomy and Clinical Anatomy(TSACA).