Protective role of sildenafil citrate in isoniazid-rifampicin induced histomorphological changes in liver of albino mice

Yıl 2021, Cilt: 15 Sayı: 1, 52 - 58, 29.04.2021

Najma Hameed , Khalid Sadozai

Öz

Objectives: The objective of the study was to reveal the reversal of histo-morphological changes in mice liver induced by combined isoniazid-rifampicin (INH-RIF) therapy with sildenafil treatment.
Methods: Twenty-one mice weighing between 25–35 g were enrolled in the study. Randomisation was carried out by simple balloting method. The selected mice were sorted into three groups with 7 mice, each group. In group C (n=7) control group, mice were administered 0.4ml of saline per kg body weight daily intra peritoneally for 21 days. In group R (n=7) INH-RIF group, rifampicin (50 mg/kg) and isoniazid (50 mg/kg), dissolved in 4 ml/kg isotonic saline, were administered intra-peritoneally (ip) daily for 21 days. In group S (n=7) sildenafil administered group, 10 mg/kg sildenafil was given orally by gastric gavage on daily basis along with the intraperitoneal injection of INH-RIF (50 mg/kg each) daily for 21 days.
Results: Histopathology revealed hepatotoxicity in group R (INH-RIF), while significant improvement was observed in group C (INH-RIF-sildenafil).
Conclusion: Sildenafil citrate possesses hepatoprotective role against INH-RIF induced hepatotoxicity.

Anahtar Kelimeler

hepatotoxicity, histomorphology, INH-RIF, oxidative stress, sildenafil citrate

Destekleyen Kurum

nil

Proje Numarası

nil

Teşekkür

thanks

Kaynakça

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