Phytotherapeutic Approaches in Breast Cancer: Biochemical and Clinical Perspectives

Mustafa Orhan Tunçel

doi:10.71133/anatphar.1687703

Phytotherapeutic Approaches in Breast Cancer: Biochemical and Clinical Perspectives

Abstract

Breast cancer remains the most prevalent cancer type in women, posing a major public health challenge due to its rising incidence and the significant strain it places on healthcare systems. Although conventional therapies remain effective, the rise in drug resistance, coupled with undesirable side effects and a decline in patient well-being, has prompted increasing attention toward complementary and alternative treatment optionsIn this regard, phytotherapy has gained significant scientific interest as a promising field of research. This review comprehensively evaluates the therapeutic effects and biochemical mechanisms of selected medicinal plants on breast cancer, based on current literature. A total of 18 phytotherapeutic plants targeting breast cancer-related cellular signaling pathways were selected from up-to-date studies. Their active constituents, apoptotic and antiproliferative effects, potential interactions with chemotherapeutic agents, and molecular targets were systematically analyzed. The examined plants primarily modulate NF-κB, PI3K/Akt, MAPK, JNK, and caspase pathways to suppress tumor growth, inhibit metastasis, and enhance chemotherapeutic efficacy. Some plants also offer advantages against multidrug resistance. Phytotherapeutic agents are increasingly recognized not just for their complementary roles but also for their potential as standalone therapeutic options in breast cancer care. However, further in-depth experimental and clinical research is crucial to connect these promising results with their practical application in clinical practice.

Keywords

Apoptosis, Breast cancer, Complementary medicine, Medicinal plants, Molecular mechanisms, Phytotherapy

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Details

Primary Language

English

Subjects

Plant Biochemistry, Cancer Biology

Journal Section

Review

Authors

Mustafa Orhan Tunçel ^*
0000-0002-8999-2223
Türkiye

Early Pub Date

December 16, 2025

Publication Date

December 19, 2025

Submission Date

April 30, 2025

Acceptance Date

October 8, 2025

Published in Issue

Year 2025 Volume: 4 Number: 3

DOI

https://doi.org/10.71133/anatphar.1687703

IZ

https://izlik.org/JA67XR63UC

APA

Tunçel, M. O. (2025). Phytotherapeutic Approaches in Breast Cancer: Biochemical and Clinical Perspectives. Anatolian Journal of Pharmaceutical Sciences, 4(3), 210-246. https://doi.org/10.71133/anatphar.1687703

AMA

1.Tunçel MO. Phytotherapeutic Approaches in Breast Cancer: Biochemical and Clinical Perspectives. AJPS. 2025;4(3):210-246. doi:10.71133/anatphar.1687703

Chicago

Tunçel, Mustafa Orhan. 2025. “Phytotherapeutic Approaches in Breast Cancer: Biochemical and Clinical Perspectives”. Anatolian Journal of Pharmaceutical Sciences 4 (3): 210-46. https://doi.org/10.71133/anatphar.1687703.

EndNote

Tunçel MO (December 1, 2025) Phytotherapeutic Approaches in Breast Cancer: Biochemical and Clinical Perspectives. Anatolian Journal of Pharmaceutical Sciences 4 3 210–246.

IEEE

[1]M. O. Tunçel, “Phytotherapeutic Approaches in Breast Cancer: Biochemical and Clinical Perspectives”, AJPS, vol. 4, no. 3, pp. 210–246, Dec. 2025, doi: 10.71133/anatphar.1687703.

ISNAD

Tunçel, Mustafa Orhan. “Phytotherapeutic Approaches in Breast Cancer: Biochemical and Clinical Perspectives”. Anatolian Journal of Pharmaceutical Sciences 4/3 (December 1, 2025): 210-246. https://doi.org/10.71133/anatphar.1687703.

JAMA

1.Tunçel MO. Phytotherapeutic Approaches in Breast Cancer: Biochemical and Clinical Perspectives. AJPS. 2025;4:210–246.

MLA

Tunçel, Mustafa Orhan. “Phytotherapeutic Approaches in Breast Cancer: Biochemical and Clinical Perspectives”. Anatolian Journal of Pharmaceutical Sciences, vol. 4, no. 3, Dec. 2025, pp. 210-46, doi:10.71133/anatphar.1687703.

Vancouver

1.Mustafa Orhan Tunçel. Phytotherapeutic Approaches in Breast Cancer: Biochemical and Clinical Perspectives. AJPS. 2025 Dec. 1;4(3):210-46. doi:10.71133/anatphar.1687703

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