Examination Of The Protective Efficiency Of The Fruit Extract And Fruit Vinegar Of The Hawthorn (Crataegus Tanacetifolia) Plant Against Hyperlipidemia And Possible Endothelial Damage In An Experimentally Induced Model Of Hyperlipidemia In Rats

Year 2025, Volume: 4 Issue: 3, 150 - 165, 19.12.2025

Celalettin Rahman Çetin Özlem Çankaya , Yakup Yılmaztekin , Ayşe Burçin Uyumlu , Basri Satılmış , İsmet Yılmaz , Metin Genç , Kadir Batçıoğlu

https://doi.org/10.71133/anatphar.1791675

https://izlik.org/JA27XE32XX

Abstract

Atherosclerosis is one of the leading causes of death in humans worldwide. Hyperlipidaemia is a significant risk factor for atherosclerosis and is characterised by accelerated atherosclerosis. However, factors such as homocysteine, adhesion molecules, and low HDL-C levels have been reported to play a role in the development of atherosclerosis and hyperlipidaemia. This study aimed to investigate the effects of hawthorn (Crataegus tanacetifolia) fruit extract and fruit vinegar on total cholesterol (TC), triglycerides (TG), Nitrit (NOx), HDL-C, LDL-C, homocysteine, P-selectin, and VCAM-1 levels, which are among the factors causing hyperlipidaemia and atherosclerosis. In the study, hawthorn extract (HE) and hawthorn vinegar (HV) were administered by gavage to rats with experimentally induced hyperlipidaemia (HL). Rats were divided into seven groups. The control group was fed a normal diet. Blood samples taken at the beginning of the study and the end of the fourth and eighth weeks were separated, and the levels of TC, TG, NOx, HDL-C, LDL-C, homocysteine, P-selectin, and VCAM-1 were measured. Our results showed that adding HE or HV to the diet reduced homocysteine, P-selectin, TC, LDL-C, NOx and TG levels and increased HDL-C levels. In conclusion, the results of this study, in which we hypothesised that hawthorn fruit extract and fruit vinegar may reduce the risk of atherosclerosis, which increases in correlation with hyperlipidaemia, hypercholesterolaemia, hyperhomocysteinemia and increased levels of adhesion molecules caused by a high-fat diet, showed that hawthorn fruit extract had a strong antiatherogenic effect

Keywords

Hawthorn , Hawthorn vinegar , Crataegus tanacetifolia , Hyperlipidaemia , Atherosclerosis

Ethical Statement

I declare that all processes of the study are in accordance with research and publication ethics, and that I comply with ethical rules and scientific citation principles.

Supporting Institution

Inonu Univertsity

Project Number

2011/148

Thanks

We would like to thank Inönü University Scientific Research Coordination Unit for providing financial support for this study.

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