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A Review on Hypoglycemic Effects of the Urtica dioica L. and Punica granatum L. Plants

Yıl 2022, Cilt: 1 Sayı: 1, 67 - 75, 31.12.2022

Öz

Diabetes mellitus is a disease characterized by insulin resistance, impaired insulin secretion, or
increased blood sugar resulting from the development of both. This disease has four forms depending on type 1, type
2, gestational diabetes and special causes. Type 2 diabetes results in the loss of body cells' ability to respond to
insulin, starting with high blood sugar. This disease is important due to its widespread occurrence in the world, high
treatment costs and no exact treatment yet. In this review, knowledge will be given about the hypoglycemic effects
of Stinging Nettle (Urtica dioica L.) and Pomegranate (Punica granatum L.) plants grown in our country.

Kaynakça

  • [1] American Diabetes A. Standards of medical care in diabetes. Diabetes Care, 2016; 39(1): 1-112.
  • [2] T.C Sağlık Bakanlığı, Halk Sağlığı Kurumu. Türkiye Diyabet Programı. https://extranet.who.int/ncdccs/Data/TUR_D1 _T%C3%BCrkiye%20Diyabet%20Program% C4%B1%202015-2020.pdf/1 October 2022.
  • [3] International Diyabetes Federation. IDF Dıabetes Atlas Tenth Edition 2021. https://diabetesatlas.org/idfawp/resourcefiles/2021/07/IDF_Atlas_10th_Edition_2021. pdf/27 October 2022.
  • [4] Şimşek A, İçen H. Kedi ve Köpeklerde Diabetes Mellitus. Dicle Üniversitesi Veteriner Fakültesi Dergisi. 2008; 1(1):23-28.
  • [5] Tanrıkulu Hİ. Türkiye’de Halk Arasında Diabetes Mellitus Tedavisinde Kullanılan Anat. J. Pharm. Sci 2022:1(1) Arctium Lappa Ekstrelerinin Streptozosin İle Hiperglisemi Yapılmış Sıçanların Kan Glikoz Seviyelerine Etkileri. Yüksek Lisans Tezi, Dumlupınar Üniversitesi, Fen Bilimleri Enstitüsü, Kütahya, 2009.
  • [6] Gaia Herbs. An Essential Guide to Nettle: History, Benefits & Uses. https://www.gaiaherbs.com/blogs/seeds-ofknowledge/an-essential-guide-to-nettlehistory-benefits-and-uses/8 Kasım 2022.
  • [7] Baytop T. Türkçe Bitki Adları Sözlüğü, Ankara, Türk Tarih Kurumu Basım Evi, 1994: 139.
  • [8] Çelebi S. Değişik konsantrasyonlarda nitrat içeren hoagland çözeltilerinde yetiştirilen Urtica dioica L. bitkilerinde nitrat birikimi. Yüksek Lisans Tezi, İstanbul Üniv. Fen Bilimleri Enstitüsü, İstanbul, 2001.
  • [9] Özcan C. Semizotu, ısırgan otu, menengiç ve kuşburnu gibi tıbbi ve aromatik bitkilerde flavonollerin HPLC-MS ile tayini. Doktora Tezi, Fırat Üniversitesi Fen Bilimleri Enstitüsü, Elazığ, 2009.
  • [10] Yalçın, B. Isırgan Otundaki (Urtica dioica) Bazı Fenolik Bileşiklerin İncelenmesi. Yüksek Lisans Tezi, Ege Üniversitesi, Fen Bilimleri Enstitüsü, İzmir, 2011.
  • [11] Akgünlü S. Kilis ve Gaziantep yöresinde tüketilen bazı yabani sebzelerin mineral içerikleri ve mikrobiyolojik analizleri. Yüksek Lisans Tezi. Fen Bilimleri Enstitüsü, Kilis, 2012.
  • [12] Baytop T. Türkiye‟nin tıbbi ve zehirli bitkileri. İsmail Akgün Matbaası, İstanbul, Türkiye. 1996: 258-259.
  • [13] Rain-Tree Publishers. The Healing Power of Rainforest Plants. The Tropical Plant Database. http://www.raintree.com/nettles.htm/8 November 2005
  • [14] Hoşbaş S. Urtica Dioica L. Bitkisi Üzerinde Farmakognozik Araştırmalar. Doctoral dissertation, Yüksek Lisans Tezi, 1s., Ankara, 2008.
  • [15] Farzami B, Ahmadvand D, Vardasbi S, Majin FJ, Khaghani S. Induction of insulin secretion by a component of Urtica dioica leave extract in perifused Islets of Langerhans and its in vivo effects in normal and streptozotocin diabetic rats. Journal of ethnopharmacology, 2003; 89(1):47-53.
  • [16] Bnouham M, Merhfour FZ, Ziyyat A, Mekhfi H, Aziz M, Legssyer A. Antihyperglycemic activity of the aqueous extract of Urtica dioica. Fitoterapia, 2003; 74(7-8): 677-681.
  • [17] Golalipour MJ, Ghafari S, Afshar M. Protective role of Urtica dioica L.(Urticaceae) extract on hepatocytes morphometric changes in STZ diabetic Wistar rats. Turkish Journal of Gastroenterology, 2010; 21(3): 262-269.
  • [18] Golalipour MJ, Balajadeh BK, Ghafari S, Azarhosh R, Khori V. Protective effect of Urtica dioica L.(Urticaceae) on morphometric and morphologic alterations of seminiferous tubules in STZ diabetic rats. Iranian journal of basic medical sciences, 2011; 14(5): 472.
  • [19] Esfade H, Mirabolghasemi G, Azarnia M. The joint effect of hydro-alcoholic extract of nettle root and metformin on ovarian tissue of diabetic model of Wistar rat. Nova Biologica Reperta, 2019; 6(2): 131-139.
  • [20] Khanaki K, Abedinzade M, Mohammadi M. The Extract of Lamium album and Urtica dioica Increase Serum Insulin-Like Growth Factor 1 Level in Streptozotocin-Induced Diabetic Rats. Zahedan Journal of Research in Medical Sciences, 2017; 19(12): e58054.
  • [21] Hussaini ZS, Askndari H, Alami K, Mousavi SY. Effect of Rheum Ribes and Urtica Dioica on type 2 diabetic rats. International Journal of Pharmaceutical and Phytopharmacological Research (eIJPPR), 2021; 11(1): 63-69.
  • [22] Jahromi HK, Dowlatkhah H, Zaer S, Afrasiabi M, Rahimipour M, Hassannezhad A, Shaterian N, Moazeni R. Urtica Dioica Extract Modifies the Gastric Tissue Changes Caused by Streptozotocin-Induced Diabetes in Male Rat. Japanese Journal of Gastroenterology and Hepatology, 2022; 8: 1-7.
  • [23] Van Den Berk Fidanlıkları. Punica granatum. https://www.vdberk.com.tr/agaclar/punicagranatum/8 November 2022.
  • [24] Chamberlain DF. Punicaceae, “Flora of Turkey and the East Aegean Islands” Cilt IV, (Ed. D.F. Chamberlain)’de, University Press, Edinburghs, 1982: 173-174.
  • [25] Davis PH. “Flora of Turkey and the East Aegean Islands”, Cilt IV, University Press, Edinburgh, 1982.
  • [26] Aksu S. Punica granatum L. Üzerinde Farmakognozik Arastırmalar. Yüksek Lisans Tezi, Hacettepe Üniversitesi, Saglık Bilimleri Enstitüsü, Ankara, 2007.
  • [27] Manav S. Nar (Punica granatum L.) meyva kabuklarını eczacılıkta degerlendirme açısından Türkiye’de yetisen dogal ve kültür nar çeşitlerinin karsılastırılması. Yüksek lisans tezi, Ankara Üniversitesi, Ankara, 1988.
  • [28] Ricci D, Giamperi L, Bucchini A, Fraternale D. Antioxidant activity of Punica granatum fruits. Fitoterapia, 2006; 77: 310– 312.
  • [29] Ephraim PL. Robert AN.Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. Journal of Ethnopharmacology, 2007;109: 177–206.
  • [30] Arun N, Singh DP. Punica granatum: a review on pharmacological and therapeutic properties. International Journal of Pharmaceutical Sciences and Research, 2012; 3(5): 1240.
  • [31] Khalil EA. Antidiabetic effect of an aqueous extract of Pomegranate (Punica granatum L.) peels in normal and alloxan diabetic rats. The Egyptian Journal of Hospital Medicine, 2004; 16(1): 92-99.
  • [32] Bhaskar A, Kumar A. Antihyperglycemic, antioxidant and hypolipidemic effect of Punica granatum L flower extract in streptozotocin induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine, 2012; 2(3): 1764-1769.
  • [33] Najafzadeh H, Aghel N, Hemmati AA, Oulapour S. Effect of hydro alcoholic extract of peel of Punica granatum on experimental diabetes mellitus by streptozotocin in rats. Pharmaceutical Sciences, 2011; 16: 239-248.
  • [34] Osman HF, Eshak MG, El-Sherbiny EM, Bayoumi MM. Biochemical and genetical evaluation of pomegranate impact on diabetes mellitus induced by alloxan in female rats. Life Science Journal, 2012; 9(3): 1543-53.
  • [35] Mestry SN, Dhodi JB, Kumbhar SB, Juvekar AR. Attenuation of diabetic nephropathy in streptozotocin-induced diabetic rats by Punica granatum Linn. leaves extract. Journal of Traditional and Complementary Medicine, 2017; 7(3): 273- 280.
  • [36] Watson RR, Preedy VR. Bioactive food as dietary interventions for diabetes. Academic Press. 2019: 641-645
  • [37] El‐Hadary AE, Ramadan MF. Phenolic profiles, antihyperglycemic, antihyperlipidemic, and antioxidant properties of pomegranate (Punica granatum) peel extract. Journal of Food Biochemistry, 2019; 43(4): 12803.
  • [38] Pottathil S, Nain P, Morsy MA, Kaur J, Al-Dhubiab BE, Jaiswal S, Nair AB. Mechanisms of antidiabetic activity of methanolic extract of punica granatum leaves in nicotinamide/streptozotocin-induced type 2 diabetes in rats. Plants, 2020; 9(11): 1609.
  • [39] Barnes J, Anderson LA, Phillipson JD. Herbal Medicines, third ed., Pharmaceutical Press, London: UK, 2007.
  • [40] Pizzorno JE, Murray MT. Textbook of Natural Medicine. Elsevier Health Sciences. 2012.
Yıl 2022, Cilt: 1 Sayı: 1, 67 - 75, 31.12.2022

Öz

Kaynakça

  • [1] American Diabetes A. Standards of medical care in diabetes. Diabetes Care, 2016; 39(1): 1-112.
  • [2] T.C Sağlık Bakanlığı, Halk Sağlığı Kurumu. Türkiye Diyabet Programı. https://extranet.who.int/ncdccs/Data/TUR_D1 _T%C3%BCrkiye%20Diyabet%20Program% C4%B1%202015-2020.pdf/1 October 2022.
  • [3] International Diyabetes Federation. IDF Dıabetes Atlas Tenth Edition 2021. https://diabetesatlas.org/idfawp/resourcefiles/2021/07/IDF_Atlas_10th_Edition_2021. pdf/27 October 2022.
  • [4] Şimşek A, İçen H. Kedi ve Köpeklerde Diabetes Mellitus. Dicle Üniversitesi Veteriner Fakültesi Dergisi. 2008; 1(1):23-28.
  • [5] Tanrıkulu Hİ. Türkiye’de Halk Arasında Diabetes Mellitus Tedavisinde Kullanılan Anat. J. Pharm. Sci 2022:1(1) Arctium Lappa Ekstrelerinin Streptozosin İle Hiperglisemi Yapılmış Sıçanların Kan Glikoz Seviyelerine Etkileri. Yüksek Lisans Tezi, Dumlupınar Üniversitesi, Fen Bilimleri Enstitüsü, Kütahya, 2009.
  • [6] Gaia Herbs. An Essential Guide to Nettle: History, Benefits & Uses. https://www.gaiaherbs.com/blogs/seeds-ofknowledge/an-essential-guide-to-nettlehistory-benefits-and-uses/8 Kasım 2022.
  • [7] Baytop T. Türkçe Bitki Adları Sözlüğü, Ankara, Türk Tarih Kurumu Basım Evi, 1994: 139.
  • [8] Çelebi S. Değişik konsantrasyonlarda nitrat içeren hoagland çözeltilerinde yetiştirilen Urtica dioica L. bitkilerinde nitrat birikimi. Yüksek Lisans Tezi, İstanbul Üniv. Fen Bilimleri Enstitüsü, İstanbul, 2001.
  • [9] Özcan C. Semizotu, ısırgan otu, menengiç ve kuşburnu gibi tıbbi ve aromatik bitkilerde flavonollerin HPLC-MS ile tayini. Doktora Tezi, Fırat Üniversitesi Fen Bilimleri Enstitüsü, Elazığ, 2009.
  • [10] Yalçın, B. Isırgan Otundaki (Urtica dioica) Bazı Fenolik Bileşiklerin İncelenmesi. Yüksek Lisans Tezi, Ege Üniversitesi, Fen Bilimleri Enstitüsü, İzmir, 2011.
  • [11] Akgünlü S. Kilis ve Gaziantep yöresinde tüketilen bazı yabani sebzelerin mineral içerikleri ve mikrobiyolojik analizleri. Yüksek Lisans Tezi. Fen Bilimleri Enstitüsü, Kilis, 2012.
  • [12] Baytop T. Türkiye‟nin tıbbi ve zehirli bitkileri. İsmail Akgün Matbaası, İstanbul, Türkiye. 1996: 258-259.
  • [13] Rain-Tree Publishers. The Healing Power of Rainforest Plants. The Tropical Plant Database. http://www.raintree.com/nettles.htm/8 November 2005
  • [14] Hoşbaş S. Urtica Dioica L. Bitkisi Üzerinde Farmakognozik Araştırmalar. Doctoral dissertation, Yüksek Lisans Tezi, 1s., Ankara, 2008.
  • [15] Farzami B, Ahmadvand D, Vardasbi S, Majin FJ, Khaghani S. Induction of insulin secretion by a component of Urtica dioica leave extract in perifused Islets of Langerhans and its in vivo effects in normal and streptozotocin diabetic rats. Journal of ethnopharmacology, 2003; 89(1):47-53.
  • [16] Bnouham M, Merhfour FZ, Ziyyat A, Mekhfi H, Aziz M, Legssyer A. Antihyperglycemic activity of the aqueous extract of Urtica dioica. Fitoterapia, 2003; 74(7-8): 677-681.
  • [17] Golalipour MJ, Ghafari S, Afshar M. Protective role of Urtica dioica L.(Urticaceae) extract on hepatocytes morphometric changes in STZ diabetic Wistar rats. Turkish Journal of Gastroenterology, 2010; 21(3): 262-269.
  • [18] Golalipour MJ, Balajadeh BK, Ghafari S, Azarhosh R, Khori V. Protective effect of Urtica dioica L.(Urticaceae) on morphometric and morphologic alterations of seminiferous tubules in STZ diabetic rats. Iranian journal of basic medical sciences, 2011; 14(5): 472.
  • [19] Esfade H, Mirabolghasemi G, Azarnia M. The joint effect of hydro-alcoholic extract of nettle root and metformin on ovarian tissue of diabetic model of Wistar rat. Nova Biologica Reperta, 2019; 6(2): 131-139.
  • [20] Khanaki K, Abedinzade M, Mohammadi M. The Extract of Lamium album and Urtica dioica Increase Serum Insulin-Like Growth Factor 1 Level in Streptozotocin-Induced Diabetic Rats. Zahedan Journal of Research in Medical Sciences, 2017; 19(12): e58054.
  • [21] Hussaini ZS, Askndari H, Alami K, Mousavi SY. Effect of Rheum Ribes and Urtica Dioica on type 2 diabetic rats. International Journal of Pharmaceutical and Phytopharmacological Research (eIJPPR), 2021; 11(1): 63-69.
  • [22] Jahromi HK, Dowlatkhah H, Zaer S, Afrasiabi M, Rahimipour M, Hassannezhad A, Shaterian N, Moazeni R. Urtica Dioica Extract Modifies the Gastric Tissue Changes Caused by Streptozotocin-Induced Diabetes in Male Rat. Japanese Journal of Gastroenterology and Hepatology, 2022; 8: 1-7.
  • [23] Van Den Berk Fidanlıkları. Punica granatum. https://www.vdberk.com.tr/agaclar/punicagranatum/8 November 2022.
  • [24] Chamberlain DF. Punicaceae, “Flora of Turkey and the East Aegean Islands” Cilt IV, (Ed. D.F. Chamberlain)’de, University Press, Edinburghs, 1982: 173-174.
  • [25] Davis PH. “Flora of Turkey and the East Aegean Islands”, Cilt IV, University Press, Edinburgh, 1982.
  • [26] Aksu S. Punica granatum L. Üzerinde Farmakognozik Arastırmalar. Yüksek Lisans Tezi, Hacettepe Üniversitesi, Saglık Bilimleri Enstitüsü, Ankara, 2007.
  • [27] Manav S. Nar (Punica granatum L.) meyva kabuklarını eczacılıkta degerlendirme açısından Türkiye’de yetisen dogal ve kültür nar çeşitlerinin karsılastırılması. Yüksek lisans tezi, Ankara Üniversitesi, Ankara, 1988.
  • [28] Ricci D, Giamperi L, Bucchini A, Fraternale D. Antioxidant activity of Punica granatum fruits. Fitoterapia, 2006; 77: 310– 312.
  • [29] Ephraim PL. Robert AN.Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. Journal of Ethnopharmacology, 2007;109: 177–206.
  • [30] Arun N, Singh DP. Punica granatum: a review on pharmacological and therapeutic properties. International Journal of Pharmaceutical Sciences and Research, 2012; 3(5): 1240.
  • [31] Khalil EA. Antidiabetic effect of an aqueous extract of Pomegranate (Punica granatum L.) peels in normal and alloxan diabetic rats. The Egyptian Journal of Hospital Medicine, 2004; 16(1): 92-99.
  • [32] Bhaskar A, Kumar A. Antihyperglycemic, antioxidant and hypolipidemic effect of Punica granatum L flower extract in streptozotocin induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine, 2012; 2(3): 1764-1769.
  • [33] Najafzadeh H, Aghel N, Hemmati AA, Oulapour S. Effect of hydro alcoholic extract of peel of Punica granatum on experimental diabetes mellitus by streptozotocin in rats. Pharmaceutical Sciences, 2011; 16: 239-248.
  • [34] Osman HF, Eshak MG, El-Sherbiny EM, Bayoumi MM. Biochemical and genetical evaluation of pomegranate impact on diabetes mellitus induced by alloxan in female rats. Life Science Journal, 2012; 9(3): 1543-53.
  • [35] Mestry SN, Dhodi JB, Kumbhar SB, Juvekar AR. Attenuation of diabetic nephropathy in streptozotocin-induced diabetic rats by Punica granatum Linn. leaves extract. Journal of Traditional and Complementary Medicine, 2017; 7(3): 273- 280.
  • [36] Watson RR, Preedy VR. Bioactive food as dietary interventions for diabetes. Academic Press. 2019: 641-645
  • [37] El‐Hadary AE, Ramadan MF. Phenolic profiles, antihyperglycemic, antihyperlipidemic, and antioxidant properties of pomegranate (Punica granatum) peel extract. Journal of Food Biochemistry, 2019; 43(4): 12803.
  • [38] Pottathil S, Nain P, Morsy MA, Kaur J, Al-Dhubiab BE, Jaiswal S, Nair AB. Mechanisms of antidiabetic activity of methanolic extract of punica granatum leaves in nicotinamide/streptozotocin-induced type 2 diabetes in rats. Plants, 2020; 9(11): 1609.
  • [39] Barnes J, Anderson LA, Phillipson JD. Herbal Medicines, third ed., Pharmaceutical Press, London: UK, 2007.
  • [40] Pizzorno JE, Murray MT. Textbook of Natural Medicine. Elsevier Health Sciences. 2012.
Toplam 40 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri
Bölüm Reviews
Yazarlar

Yakup Yılmaztekin Bu kişi benim 0000-0002-8676-4487

Yayımlanma Tarihi 31 Aralık 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 1 Sayı: 1

Kaynak Göster

EndNote Yılmaztekin Y (01 Aralık 2022) A Review on Hypoglycemic Effects of the Urtica dioica L. and Punica granatum L. Plants. Anatolian Journal of Pharmaceutical Sciences 1 1 67–75.

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