DENEYSEL ARTRİT MODELİNDE İNTRAARTİKOLER HYALURONIK ASİT VE METİL PREDNİSOLON ASETATIN KIKIRDAK OZERİNE ETKİLERİ / EFFECTS OF INTRAARTICULAR HYALURONIC ACID AND METHYL PREDNISOLONE ACETATE ON CARTILAGE IN A MODEL OF EXPERIMENTAL ARTHRITIS

Yıl 2002, Cilt: 4 Sayı: 1, 0 - 0, 20.02.2010

Şirzat Çoğalgil Orhan Karsan Lale Cerrahoğlu Halis Süleyman Cemal Gündoğdu Fazlı Erdoğan

Öz

Dejeneratil artritlerde intraartikuler olarak uygulanan hyaluronik asit (HA) ve metil prednisolon asetat (MPA)
tedavilerinin etkilerini ara$tlrmak i9in deneysel bir 9all!~ma yaplldl. 40 adet erkek raM sag arka diz eklemleri
i9ine 0.2 ml %1'lik lormalin veriierek deneysel artrit olu$turuldu. IIa9 verilmesinden bir hafta sonra 10 rat
61dunJlerek artrilin olu$tugu histopatolojik olarak be/iriendi. Kalan 30 rat 3 gruba aynldl. Birinci gruba 0.05 ml
intraartikiiler HA (HA grubu), ikinci gruba 0.05 ml intraartikLiler MPA (MPA grubu) verildi. 09uncu gruba ise
intraartikiiler 0.05 ml serum lizyolojik venlerek kontrol grubu olu$turuldu. Tedaviler artrit olu$turulduktan sonra
7. Gun, 14. Gun ve 21. gun uygulandl. Uygulanan bu tedavilerin bitiminden 15 giin sonra rat/ar 61duriildu ve
alman omekler, histopatolojik olarak incelendi.
Yapilan incelemede; MPA grubunda klkmjak iyile$mesi a9lsmdan kontrol grubuna g6re anlaml! fark
bulunamadl (p>0.05). HA grubunda ise klklrdak iyile$mesi MPA ve kontrol grubuna gore anlamli olarak
yiiksek bulundu (p<0.05).
Intraartikiiler artrit tedavisinde klklrdak dokusu uzerine olumlu etkilerinden dolaYI HA'in MPA 'a g6re daha
yararll oldugu sonucuna vanldl.

Anahtar kelimeler: Oeneysel artrit, klklrdak, hyaluronik asit, metil prednisolon asetat.

SUMMARY
This experimental study was performed to determine the effects of intraarticular hyaluronic acid (HA) and
methyl prednisolone acetate (MPA) in degenerative osteoarthritis. 0.2 ml 1% formaline were injected to the
posterior right knee joints of 40 male rats. One week after the injections. 10 rats were killed and arthritis was
determined histopathologically. The remained 30 rats were divided to three groups. First group received
intraarticularly 0.05 ml HA (HA group), second group 005 ml MPA (MPA group) and third group 0.05 ml saline
as controls. The injections were performed at 7., 14. and 21- days after the arthritis. 15 days after the end of
these treatments, rats were killed and sections were examined histopathologically.
There was no significantly difference in cartilage healing between MPA and control groups (p>0.05). However
cartilage healing was significantly high in HA group compared to MPA and control groups (p<0.05).
It was concluded that HA is more useful than MPA in the treatment of arthritis intraarticularfy because of its
positive effects on cartilage tissue.

Key words: Experimental arthritis, cartilage, hyaluronic acid, methyl prednisolone acetate.