First Detection of Hypomyelination Associated With Bovine Viral Diarrhoea Virus in an Aborted Calf in Gumushane Region

Yıl 2016, Cilt: 11 Sayı: 1, 0 - 0, 25.04.2016

Güngör Çağdaş Dinçel , Nezihe Gökhan

https://doi.org/10.17094/avbd.98342

Öz

In this study, hydranencephaly and mild cerebellar hypoplasia were reported macroscopically, microscopically and immunohistochemically in an aborted Holstein Friesian calf. A relationship between Bovine Viral Diarrhoea Virus (BVDV) infection and histopathology associated with the central nervous system (CNS) lesions were demonstrated. In the histopathology, perivascular haemorrhage, oedema, neuronal necrosis and degeneration were observed in the CNS. BVDV positive immunoreaction was detected in neurons, glial and endothelial cells of CNS by immunohistochemical examination. As far as the authors are concerned, this is the first report of BVDV present in an aborted Holstein Friesian Calf in Gumushane region. This finding may have important implications for the epidemiology and control of BVDV infection in the Gumushane region.

Anahtar Kelimeler

Hidranensefali, Hipomyelinizasyon, Serebellar hipoplazi, Sığırların Virüsi İshali

Kaynakça

• Barlow RM., Nettleton PF., Gardiner AC., Greig A., Campell JR., Broon JM., 1986. Persistent bovine viral diarrhoea virus infection in a bull. Veterinary Record, 118, 321-324.
• Baker JC., 1987. Bovine viral diarrhea virus: A reviev. American Veterinary Medical Association, 190, 1449-1458.
• Atmaca HT., Dinçel GÇ., Kumandaş A., Kul O., Orhan İÖ., 2012. Central nervous system and skull malformations associated with Bovine Viral Diarrhea Virus in a calf. Veterinary Journal of Ankara University, 59, 223-226.
• Dincel GC., Kul O., 2015. Increased expressions of ADAMTS-13, neuronal nitric oxide synthase, and neurofilament correlate with severity of neuropathology in border disease virus-infected small ruminants. PLoS One, 10, 1-11.
• Dincel GC., Kul O., 2015. eNOS and iNOS trigger apoptosis in the brains of sheep and goats naturally infected with the border disease virus. Histology Histopathology, 10, 1233-1242.
• Radostits OM., Littlejohns IR., 1988. New concepts in the pathogenesis, diagnosis and control of diseases caused by the bovine viral diarrhea virus. Canadian Veterinary Journal, 29, 513-528.
• Miura Y., Kubo M., Goto Y., Kono Y., 1990. Hydranencephaly-cerebellar hypoplasia in a newborn calf after infection of its dam with Chuzan virus. Nippon Juigaku Zasshi, 52, 689- 694.
• Kul O., Kabakcı N., Özkul A., Kalender H., Atmaca HT., 2008. Concurrent peste des petits ruminants virus and pestivirus infection in stillborn twin lambs. Veterinary Pathology, 45, 191-196.
• Liess B., 1990. Bovine viral Diarrhea virus. In “Virus Infections of Ruminant”, Ed., Dinter Z and Morein B, Elsevier, Netherlands.
• Paton DJ., 1995. Pestivirus diversity. Journal of Comparative Pathology, 112, 215-236.
• MacLachlan NJ., Osburn BI., 1988. Congenital bluetongue virus infection. Progress in clinical and biological research, 281, 33-47.
• Evans CA., Lanyon SR., Sims SK., Reichel MP., 2014. Reproductive performance in experimentally BVDV infected ewes and seroconversion rates in sheep co-mingled with BVDV PI calves. Small Ruminant Research, 123, 314-319.