Investigation of The Stabilization of Camptothecin Anticancer Drug via PSA-PEG Polymeric Particles

Dilay Kizisar; N. Tuna Subasi; Serap Eroksuz; Ayhan S. Demir; Olcay Mert

doi:10.18038/btda.87862

TR EN

INVESTIGATION OF THE STABILIZATION OF CAMPTOTHECIN ANTICANCER DRUG VIA PSA-PEG POLYMERIC PARTICLES

Abstract

Nano ve mikro taşıyıcı oluşumu için biyolojik olarak parçalanabilen PSA:PEG kopolimerlerinin sentezleri gerçekleştirilmiştir. Kamptotesin (CPT), antikanser ilaç olarak seçilmiştir. CPT fizyolojik koşullar altında kolay hidrolize olabilir (pH=7.4). Bu aktivite kaybına yol açar ve ilaç aktif lakton formundan aktif olmayan zehirli karboksilat forma dönüşür. Bu çalışmada anti kanser ilacı lakton formunda tutmak için, CPT etkili bir şekilde PSA:PEG nanopartikül ve mikropartiküllere yüklenmiştir ve taşıyıcı içindeki CPT kararlılığı detaylı bir şekilde HPLC ile incelenmiştir. Nano ve mikro taşıyıcılar içinde ilacın yüksek derecede kararlı ve aktif biçimde olduğu bulunmuştur (> % 95). Son olarak parçacıklar konfokal, SEM ve optik mikroskoplar ile görüntülenmiştir

References

Hou S, McCauley L K, Ma P X. Synthesis and erosion properties of PEG-containing Polyanhydrides. Macromol Biosci 2007; 7: 620–628.
Shuai X, Tan H. Synthesis and properties of biodegradable copolymers based on polyether oligomers and fatty diacids. J Appl Polym Sci 1997; 66: 1891–1898.
Domb A J, Langer R. Polyanhydrides. I. Preparation of high molecular weight polyanhydrides. J Polym Sci A1 1987; 25: 3373-3386.
Kumara N, Langer R S, Domb A J. Polyanhydrides: an overview. Adv Drug Deliver Rev 2002; 54: 889– 910.
Fu J, Fiegel J, Hanes J. Synthesis and characterization of PEG-based ether−anhydride terpolymers: novel polymers for controlled drug delivery. Macromolecules 2004; 37: 7174-7180.
Fu J, Fiegel J, Krauland E, Hanes J, New polymeric carriers for controlled drug delivery following inhalation or injection. Biomaterials 2002; 23: 4425–4433.
Lee J, Joo M K, Oh H, Sohn Y S, Jeong B. Injectable gel: poly(ethylene glycol)-sebacic acid polyester. Polymer 2006; 47: 3760–3766.
Tang BC, Dawson M, Lai S K, Wang Y Y, Zeitlin P, Boyle M P, Fu J, Hanes J. Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier. Pro Natl Acad Sci USA 2009; 106: 19268-73.
Tang B C, Fu J, Watkins D N, Hanes J, Enhanced efficacy of local etoposide delivery by poly(ether-anhydride) particles against small cell lung cancer in vivo. Biomaterials 2010; 31: 339–44.
Wall M E, Wani M C, Cook C E, Palmer K H, McPhail A T, Sim G A. Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from camptotheca acuminata. J Am Chem Soc 1966; 88: 3888-90.

Hsiang Y H, Hertzberg R, Hecht S, Liu L F. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem 1985; 260(27): 14873-14878.
Oberlies N H, Kroll D J, Camptothecin and taxol: historic achievements in natural products research. J Nat Prod 2004; 67(2): 129-135.
Fassberg J, Stella V J, A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues. J Pharm Sci 1992; 81: 676-684.
Wani M C, Nicholas A W, Manikumar G, Wall M E. Plant antitumor agents. 25. Total synthesis and antileukemic activity of ring A substituted camptothecin analogs. structure-activity correlations. J Med Chem 1987; 30: 1774-1779.
Wani M C, Nicholas A W, Wall M E. Plant antitumor agents. 28. Resolution of a key tricyclic synthon, 5'(RS)-1,5-dioxo-5'-hydroxy-2'H,5'H,6'H-6'-oxopyrano[3',4'-f].delta.6,8-tetrahydroindolizine: total synthesis and antitumor activity of 20(S)- and 20(R)-camptothecin. J Med Chem 1987; 30: 2317-2319.
Jaxel C, Kohn K W, Wani M C, Wall M E. Pommier, Y. Structure-Activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity. Cancer Res 1989; 49: 1465-1469.
Moertel C G, Schutt A J, Reitemeier R J, Hahn R G. Phase II study of camptothecin (NSC- 100880) in the treatment of advanced gastrointestinal cancer. Cancer Chemoth Rep 1972; 56: 95-101.
Gottlieb J A, Luce J K. Treatment of malignant melanoma with camptothecin. Cancer Chemoth Rep 1972; 56: 103-105.
Dancey J, Eisenhauer E A. Current perspectives on camptothecins in cancer treatment. Br J Cancer 1996; 74: 327-338.
Pommier Y, Pourquier P, Fan Y, Strumberg D. Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme. Biochim Biophys Acta 1998; 1400: 83-106.
Shenderova A, Burke T G, Schwendeman S P. Stabilization of 10-Hydroxycamptothecin in poly(lactide-co-glycolide) microsphere delivery vehicles. Pharm Res 1997; 14: 1406-1414.
McCarron P A, Marouf W M, Quinn D J, Fay F, Burden R E, Olwill S A, Scott C J. Antibody targeting of camptothecin-loaded PLGA nanoparticles to tumor cells. Bioconjugate Chem 2008; 19: 1561-1569.
Tong R, Cheng J. Controlled Synthesis of Camptothecin−Polylactide Conjugates and Nanoconjugates. Bioconjugate Chem 2010; 21: 111-121.
Yang D, Strode J T, Spielmann H P, Wang A H-J, Burke T G. DNA Interactions of two clinical camptothecin drugs stabilize their active lactone forms. J Am Chem Soc 1998; 120: 2979-2980.
Liu J, Jiang Z, Zhang S, Saltzman W M. Poly(ω-pentadecalactone-co-butylene-co-succinate) nanoparticles as biodegradable carriers for camptothecin delivery. Biomaterials 2009; 30: 5707-5719.
Wani M C, Ronman P E, Lindley J T, Wall M E. Plant antitumor agents. 18. synthesis and biological activity of camptothecin analogs. J Med Chem 1980; 23: 554-560.
Mert O, Esendaglı G, Dogan A L, Demir A S. Injectable biodegradable polymeric system for preserving the active form and delayed-release of camptothecin anticancer drugs. RSC Adv 2012; 2: 176- 185.
Warner D L, Burke T G. Simple and versatile high-performance liquid chromatographic method for the simultaneous quantitation of the lactone and carboxylate forms of camptothecin anticancer drugs, J Chromatogr B Biomed Sci Appl 1997; 691: 161-171.

Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Dilay Kizisar This is me

N. Tuna Subasi

Serap Eroksuz This is me

Ayhan S. Demir This is me

Olcay Mert

Publication Date

April 25, 2016

Submission Date

February 9, 2016

Acceptance Date

-

Published in Issue

Year 2016 Volume: 17 Number: 1

DOI

https://doi.org/10.18038/btda.87862

IZ

https://izlik.org/JA62GW67SR

APA

Kizisar, D., Subasi, N. T., Eroksuz, S., Demir, A. S., & Mert, O. (2016). Investigation of The Stabilization of Camptothecin Anticancer Drug via PSA-PEG Polymeric Particles. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering, 17(1), 221-231. https://doi.org/10.18038/btda.87862

AMA

1.Kizisar D, Subasi NT, Eroksuz S, Demir AS, Mert O. Investigation of The Stabilization of Camptothecin Anticancer Drug via PSA-PEG Polymeric Particles. AUJST-A. 2016;17(1):221-231. doi:10.18038/btda.87862

Chicago

Kizisar, Dilay, N. Tuna Subasi, Serap Eroksuz, Ayhan S. Demir, and Olcay Mert. 2016. “Investigation of The Stabilization of Camptothecin Anticancer Drug via PSA-PEG Polymeric Particles”. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering 17 (1): 221-31. https://doi.org/10.18038/btda.87862.

EndNote

Kizisar D, Subasi NT, Eroksuz S, Demir AS, Mert O (June 1, 2016) Investigation of The Stabilization of Camptothecin Anticancer Drug via PSA-PEG Polymeric Particles. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering 17 1 221–231.

IEEE

[1]D. Kizisar, N. T. Subasi, S. Eroksuz, A. S. Demir, and O. Mert, “Investigation of The Stabilization of Camptothecin Anticancer Drug via PSA-PEG Polymeric Particles”, AUJST-A, vol. 17, no. 1, pp. 221–231, June 2016, doi: 10.18038/btda.87862.

ISNAD

Kizisar, Dilay - Subasi, N. Tuna - Eroksuz, Serap - Demir, Ayhan S. - Mert, Olcay. “Investigation of The Stabilization of Camptothecin Anticancer Drug via PSA-PEG Polymeric Particles”. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering 17/1 (June 1, 2016): 221-231. https://doi.org/10.18038/btda.87862.

JAMA

1.Kizisar D, Subasi NT, Eroksuz S, Demir AS, Mert O. Investigation of The Stabilization of Camptothecin Anticancer Drug via PSA-PEG Polymeric Particles. AUJST-A. 2016;17:221–231.

MLA

Kizisar, Dilay, et al. “Investigation of The Stabilization of Camptothecin Anticancer Drug via PSA-PEG Polymeric Particles”. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering, vol. 17, no. 1, June 2016, pp. 221-3, doi:10.18038/btda.87862.

Vancouver

1.Dilay Kizisar, N. Tuna Subasi, Serap Eroksuz, Ayhan S. Demir, Olcay Mert. Investigation of The Stabilization of Camptothecin Anticancer Drug via PSA-PEG Polymeric Particles. AUJST-A. 2016 Jun. 1;17(1):221-3. doi:10.18038/btda.87862

Investigation of The Stabilization of Camptothecin Anticancer Drug via PSA-PEG Polymeric Particles

INVESTIGATION OF THE STABILIZATION OF CAMPTOTHECIN ANTICANCER DRUG VIA PSA-PEG POLYMERIC PARTICLES

Abstract

Investigation of The Stabilization of Camptothecin Anticancer Drug via PSA-PEG Polymeric Particles

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite