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Abstract

In the present study, an electrospinning procedure was carried out in order to develop a simple and effective tool for fabricating gelatin/bioactive glass (Gt/BG) nanofibers with a controllable and predictable fiber diameter. For this purpose, a quadratic model was obtained within the context of response surface methodology based on a three-level, three-variable Box–Behnken design technique to describe the relationship between the fiber diameter and the electrospinning parameters, namely BG content, tip-to-collector distance, and flow rate. Meanwhile, the quality of fit of the model was evaluated by the coefficients of determination (R-square) and the analysis of variances. Moreover, the adequacy of the model was examined by conducting additional experiments that were not employed in the model generation

Keywords

• Electrospinning, Gelatin, Bioactive glass, Fiber diameter, Response surface methodology

ELEKTROSPİNNİNG PARAMETRELERİNİN JELATİN/BİYOAKTİF CAM NANOLİF YAPISI ÜZERİNDEKİ ETKİLERİNİN İNCELENMESİ

Abstract

Bu çalışmada, malzeme ve proses değişkenlerinin jelatin/biyoaktif cam (Gt/BG) nanokompozit liflerinin çapı üzerindeki etkilerinin incelenmesi hedeflenmiştir. Bu amaçla; farklı oranlarda biyoaktif cam tozu içeren jelatin çözeltilerine elektrospinning işlemi uygulanarak nanokompozit malzemeler üretilmiştir. Biyoaktif cam içeriğinin, uç ile toplayıcı arasındaki açıklığın ve çözelti akış hızının ortalama lif çapı üzerindeki etkileri yanıt yüzey yöntemi kullanılarak incelenmiştir. Sonuç olarak; üç değişkenli ve üç seviyeli Box–Benkhen tasarım yöntemi kullanılarak ikinci dereceden bir model oluşturulmuş ve geliştirilen bu model aracılığı ile değişkenlerin etkinlikleri değerlendirilerek, hedeflenen lif çapının sağlanması için gerekli proses koşullarının tahmin edilebileceği basit ve etkin bir yöntem geliştirilmiştir.

Keywords

• Elektrospinning; Jelatin; Biyoaktif Cam; Lif Çapı; Yanıt Yüzey Yöntemi

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