Gerçek Yaşam Çalışması: Miyeloproliferatif Neoplazm Hastalarında Pegile İnterferon Alfa- 2a’nın Etkinliği ve Güvenliği

Year 2025, Volume: 78 Issue: 1, 60 - 68, 31.03.2025

Derya Koyun , Güldane Cengiz Seval , Sinem Civriz Bozdağ Selami Koçak Toprak , Pervin Topçuoğlu , Önder Arslan , Muhit Özcan

https://doi.org/10.4274/atfm.galenos.2025.36744

Abstract

Amaç: Bazı klinik çalışmalarda, pegile interferon alfa-2a (PEG-IFN-α-2a) ile tedavi edilen esansiyel trombositemi (ET) ve polisitemia vera (PV)
hastalarında umut verici sonuçlar bildirmiştir. Biz de bu çalışmada, kendi kliniğimizde takip ve tedavi ettiğimiz miyeloproliferatif neoplazm (MPN)
tanılı hastalarımızda PEG-IFN-α-2a etkinlik ve güvenilirliğini değerlendirdik.
Gereç ve Yöntem: Bu retrospektif analizde, 2014 ve 2021 yılları arasında tanı almış ve PEG-IFN-α-2a ile tedavi edilmiş, 39 MPN tanılı hastanın (25
ET, 13 PV, 1 primer miyelofibrozis) sonuçlarını sunduk.
Bulgular: Hastaların ortanca yaşı 49 (aralık, 23-71) olup, çoğunluğu (%92) daha önce en az bir sıra farklı sitoredüktif tedaviyi almıştı. PEG-IFN-α-
2a’nın ortanca başlangıç dozu 126 mcg/hafta (aralık, 22,5-180 mcg/hafta) olup, hastalar tedaviyi kendine-enjeksiyon ile uygulanmıştır. Hastalar
ortanca 24 ay (aralık, 1-77) tedavi almıştır. Polisitemi vera ve ET tanılı hastalarda tüm yanıt oranları sırasıyla %84,6 ve %92 olarak bulunmuştur. Tüm
hastalar arasında tedavi süresinde gözlemlenen en yaygın yan etkiler yorgunluk (%71), miyalji (%54) ve artralji (%53) olmuştur.
Sonuç: Sonuçlarımız, PEG-IFN-α-2a’nın, özellikle uzun süreli sitotoksik tedaviden kaçınmak isteyen daha genç hastalar için uygulanabilir bir tedavi
seçeneği olabileceğini göstermektedir.

Keywords

Pegile interferon alfa-2a , polisitemia vera

Project Number

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Gerçek Yaşam Çalışması: Miyeloproliferatif Neoplazm Hastalarında Pegile İnterferon Alfa2a’nın Etkinliği ve Güvenliği

Abstract

Objectives: Several clinical studies have reported promising results in patients with essential thrombocythemia (ET) and polycythemia vera (PV)
treated with pegylated interferon alpha-2a (PEG-IFN-α-2a). In this study, we evaluated the efficacy and safety of PEG-IFN-α-2a in patients with
myeloproliferative neoplasms (MPNs) followed and treated in our clinic.
Materials and Methods: In this retrospective analysis, we present the outcomes of 39 patients diagnosed with MPNs (25 with ET, 13 with PV, 1 with
primary myelofibrosis) who received PEG-IFN-α-2a between 2014 and 2021.
Results: The average age of the participants was 49 years, ranging from 23 to 71. Most patients (92%) had received at least one prior cytoreductive
therapy. The median starting dose of PEG-IFN-α-2a was 126 mcg/week (range, 22.5-180 mcg/week), administered by self-injection. The median
duration of treatment was 24 months (range, 1-77). The overall response rates in patients with PV and ET were 84.6% and 92%, respectively. The
most common adverse events observed during the treatment period were fatigue (71%), myalgia (54%), and arthralgia (53%).
Conclusion: Our results suggest that PEG-IFN-α-2a remains a feasible treatment option, particularly for younger patients who wish to avoid
prolonged cytotoxic therapy.

Keywords

Pegylated interferon alpha-2a , polycythemia vera , essential thrombocythemia

Ethical Statement

Ethics Committee Approval: The study was approved by the Ankara University Faculty of Medicine Human Research Ethics Committee (date: 10.12.2021, approval no.: İ10-663-21).

Supporting Institution

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Project Number

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Thanks

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