The Mediating Effect of Caudate Nucleus Dopaminergic Activity on the Relationship Between Age and Cognitive Functions in Parkinson’s Disease Patients

Evrim Gökçe

doi:10.4274/atfm.galenos.2024.15010

EN TR

The Mediating Effect of Caudate Nucleus Dopaminergic Activity on the Relationship Between Age and Cognitive Functions in Parkinson’s Disease Patients

Abstract

Objectives: Advancing age is the primary risk factor for Parkinson’s disease (PD). In PD patients, dopaminergic activity is impaired, and cognitive dysfunctions are observed. This study investigated the mediating effect of caudate nucleus dopamine transporter binding score on the relationship between age and cognition in PD patients. Materials and Methods: The open database of the Michael J. Fox Association was used, and data on 1,099 PD patients were accessed. Cognitive function scores and single-photon emission tomography findings assessing caudate nucleus dopaminergic activity were used. Results: The caudate nucleus dopamine transporter binding score mediated the relationship between age and attention, processing speed, linguistic function, working memory, verbal episodic memory, and visual-spatial functions. Conclusion: The cumulative neurodegenerative effect of age and PD requires monitoring of cognitive function. This study emphasizes the significance of considering dopaminergic activity in the caudate nucleus for diagnosing, monitoring, and treating cognitive functions in Parkinson’s disease.

Keywords

Parkinson’s disease, mediation analysis, cognition, caudate nucleus, dopamine transporter

Ethical Statement

The PPMI protocol was reviewed and approved by the Institutional Review Board and the Independent Ethics Committee (IRB/IEC) at each center and the study followed the Guideline for Good Clinical Practice. This study obtained the right to use the PPMI database data

Parkinson Hastalarında Kaudat Çekirdek Dopaminerjik Aktivitesinin Yaş ve Bilişsel İşlevler Arasındaki İlişkiye Aracılık Etkisi

Abstract

Amaç: İlerleyen yaş, Parkinson hastalığı için birincil risk faktörüdür. Parkinson hastalarında, dopaminerjik aktivite bozulur ve bilişsel işlev bozuklukları görülür. Bu çalışmanın amacı, Parkinson hastalarında yaş ve biliş ilişkisinde, kaudat çekirdek dopamin taşıyıcısı bağlanma skorunun aracılık etkisinin araştırılmasıdır. Gereç ve Yöntem: Michael J. Fox Derneğinin erişime açık veritabanı kullanılmış, 1.099 Parkinson hastasının verilerine erişim sağlanmıştır. Hastaların bilişsel işlev puanları ve kaudat çekirdek dopaminerjik aktivitesini değerlendiren tek foton emisyon tomografisi bulguları kullanılmıştır. Bulgular: Kaudat çekirdek dopamin taşıyıcısı bağlanma skoru, yaş ile dikkat, işlem hızı, dilsel işlev, çalışma belleği, sözel epizodik bellek ve görseluzamsal işlevler arasındaki ilişkiye aracılık etmiştir. Sonuç: Yaş ve Parkinson hastalığının kümülatif nörodejeneratif etkisi, bilişsel işlevlerin takibini gerektirmektedir. Bu çalışma, Parkinson hastalığında bilişsel işlevlerin tanı, takip ve tedavisinde, kaudat çekirdek dopaminerjik aktivitesinin dikkate alınmasının önemini vurgulamaktadır.

Keywords

Parkinson hastalığı, aracılık analizi, biliş, kaudat çekirdek, dopamin taşıyıcısı

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Details

Primary Language

English

Subjects

Neurology and Neuromuscular Diseases

Journal Section

Research Article

Authors

Evrim Gökçe ^*
0000-0003-1548-8785
France

Publication Date

December 31, 2024

Submission Date

July 29, 2024

Acceptance Date

October 22, 2024

Published in Issue

Year 2024 Volume: 77 Number: 4

DOI

https://doi.org/10.4274/atfm.galenos.2024.15010

IZ

https://izlik.org/JA65UB77YM

APA

Gökçe, E. (2024). The Mediating Effect of Caudate Nucleus Dopaminergic Activity on the Relationship Between Age and Cognitive Functions in Parkinson’s Disease Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 77(4), 367-373. https://doi.org/10.4274/atfm.galenos.2024.15010

AMA

1.Gökçe E. The Mediating Effect of Caudate Nucleus Dopaminergic Activity on the Relationship Between Age and Cognitive Functions in Parkinson’s Disease Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2024;77(4):367-373. doi:10.4274/atfm.galenos.2024.15010

Chicago

Gökçe, Evrim. 2024. “The Mediating Effect of Caudate Nucleus Dopaminergic Activity on the Relationship Between Age and Cognitive Functions in Parkinson’s Disease Patients”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 77 (4): 367-73. https://doi.org/10.4274/atfm.galenos.2024.15010.

EndNote

Gökçe E (December 1, 2024) The Mediating Effect of Caudate Nucleus Dopaminergic Activity on the Relationship Between Age and Cognitive Functions in Parkinson’s Disease Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası 77 4 367–373.

IEEE

[1]E. Gökçe, “The Mediating Effect of Caudate Nucleus Dopaminergic Activity on the Relationship Between Age and Cognitive Functions in Parkinson’s Disease Patients”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 77, no. 4, pp. 367–373, Dec. 2024, doi: 10.4274/atfm.galenos.2024.15010.

ISNAD

Gökçe, Evrim. “The Mediating Effect of Caudate Nucleus Dopaminergic Activity on the Relationship Between Age and Cognitive Functions in Parkinson’s Disease Patients”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 77/4 (December 1, 2024): 367-373. https://doi.org/10.4274/atfm.galenos.2024.15010.

JAMA

1.Gökçe E. The Mediating Effect of Caudate Nucleus Dopaminergic Activity on the Relationship Between Age and Cognitive Functions in Parkinson’s Disease Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2024;77:367–373.

MLA

Gökçe, Evrim. “The Mediating Effect of Caudate Nucleus Dopaminergic Activity on the Relationship Between Age and Cognitive Functions in Parkinson’s Disease Patients”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 77, no. 4, Dec. 2024, pp. 367-73, doi:10.4274/atfm.galenos.2024.15010.

Vancouver

1.Evrim Gökçe. The Mediating Effect of Caudate Nucleus Dopaminergic Activity on the Relationship Between Age and Cognitive Functions in Parkinson’s Disease Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2024 Dec. 1;77(4):367-73. doi:10.4274/atfm.galenos.2024.15010

The Mediating Effect of Caudate Nucleus Dopaminergic Activity on the Relationship Between Age and Cognitive Functions in Parkinson’s Disease Patients

Abstract

Keywords

Ethical Statement

Parkinson Hastalarında Kaudat Çekirdek Dopaminerjik Aktivitesinin Yaş ve Bilişsel İşlevler Arasındaki İlişkiye Aracılık Etkisi

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

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