Clinicoepidemiologic Characteristics and Prevalence of Venous Insufficiency in Patients with Pigmented Purpuric Dermatosis

Abstract

Objectives: To describe clinic-epidemiological characteristics of pigmented purpuric dermatosis (PPD) and to assess the potential relationship between venous insufficiency and PPD. Materials and Methods: We retrospectively reviewed the medical records of all patients diagnosed with PPD at University of Health Sciences Türkiye, İstanbul Training and Research Hospital dermatology clinics between January 2010 and September 2022. Clinical, demographic, and radiological characteristics were examined. Results: The study included a total of 195 PPD patients, of whom 111 were female (57%). The mean age of the patients was 44.25±19.99 years, and the average disease duration was 15.4±24.1 months. The most common subtype of the disease was Schamberg’s disease (66%), followed by Majocchi’s disease (16%), lichen aureus (8%), pigmented purpuric lichenoid dermatitis of Gougerot-Blum (7%), and eczematid-like purpura of Doucas and Kapetanakis (2%). Almost all patients (99%) had lesions on their lower extremities, while only 26 (13%) had lesions on the upper body. Lesion distribution was bilateral in 167 (87%) of the cases. Venous Doppler ultrasonography was performed in 101 patients, with venous insufficiency detected in 24 (23.8%) of them. There were no statistically significant differences in terms of age, gender, and disease duration between patients with and without venous insufficiency. There was no correlation between the laterality of venous insufficiency and the laterality of lesion distribution. Conclusion: Considering venous insufficiency is reported to affect 7% to 30% of the general population, our study implies that its occurrence in PPD patients may not be higher than in the general population, contrary to prior research. Key Words: Venous insufficiency, pigmented purpuric eruption, doppler ultrasonography, pigmentation disorders

Keywords

• Venous insufficiency
• pigmented purpuric eruption
• doppler ultrasonography
• pigmentation disorders

Ethical Statement

The study protocol was approved by the University of Health Sciences Türkiye, İstanbul Training and Research Hospital Institutional Review Board (IRB no: 2011-KAEK-50-369).

Pigmente Purpurik Dermatoz Hastalarında Klinik-Epidemiyolojik Özellikler ve Venöz Yetmezlik Sıklığının İncelenmesi

Abstract

Amaç: Pigmente purpurik dermatozların (PPD) klinik ve epidemiyolojik özelliklerini tanımlamak ve hastalığın venöz yetmezlik ile olası ilişkisini araştırmaktır. Gereç ve Yöntem: Ocak 2010 ile Eylül 2022 tarihleri arasında Sağlık Bilimleri Üniversitesi, İstanbul Eğitim ve Araştırma Hastanesi dermatoloji polikliniklerine başvuran, histopatolojik olarak PPD tanısı konmuş tüm hastaların dosyaları retrospektif olarak taranarak; klinik, demografik ve radyolojik özellikleri kaydedildi. Bulgular: Çalışmaya 111’i kadın (%57) toplam 195 PPD hastası dahil edilmiş olup, hastaların ortalama yaşı 44,25±19,99 idi. Ortalama hastalık süresi 15,4±24,1 aydı. En sık tespit edilen hastalık subtipi Schamberg hastalığı (%66) iken bunu sırası ile Majocchi hastalığı (%16), liken aureus (%8), Gougerot-Blum’un likenoid pigmente purpurik dermatiti, (%7) ve Doucas ve Kapetanakis’in egzama benzeri purpurası (%2) izledi. Hastaların neredeyse tamamında (%99) alt ekstremitede lezyon bulunurken, yalnızca 26 (%13) hastada bel üstü vücut bölgelerinde lezyon tespit edildi. Lezyonların dağılımı 167 (%87) hastada bilateraldi. Alt ekstremite venöz Doppler ultrasonografi incelemesi 101 hastada yapılmış olup, bunların 24’ünde (%23,8) venöz yetmezlik tespit edildi. Venöz yetmezlik tespit edilen ve edilmeyen hastalar arasında yaş, cinsiyet, hastalık süresi açısından istatistiksel olarak anlamlı fark bulunmadı. Venöz yetmezlik lateralitesi ile lezyon dağılımların lateralitesi arasında korelasyon bulunmadı. Sonuç: Genel popülasyonda venöz yetmezlik prevalansının %7-30 arasında değişen sıklıkla bildirildiği göz önüne alındığında, bizim çalışmamızda önceki çalışmalardan farklı olarak PPD hastalarında venöz yetmezlik görülme sıklığının topluma göre artmış olmadığı düşünülmüştür. Anahtar Kelimeler: Venöz yetmezlik, pigmente purpurik dermatoz, doppler ultrasonografi, pigmentasyon bozuklukları

Keywords

• Venöz yetmezlik
• pigmente purpurik dermatoz
• doppler ultrasonografi
• pigmentasyon bozuklukları

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