Serum Chitotriosidase Activity in Bronchopulmonary Dysplasia: A Cross-Sectional Study

Year 2022, Volume: 75 Issue: 4, 491 - 496, 20.01.2023

Fatma Tuba Eminoğlu , Elif Keleştemur Özlem Doğan , Engin Köse , Zehra Şule Haskoloğlu , Fatma Nazan Çobanoğlu

Abstract

Objectives: Serum chitotriosidase (CHIT1) is a novel and promising biomarker of inflammatory diseases including airway and lung diseases. To date,
there are no studies regarding serum CHIT1 activity in bronchopulmonary dysplasia (BPD) patients for determining inflammation. The aim of this
study was to investigate whether serum CHIT1 activity is a useful marker for determining inflammation in BPD patients.

Materials and Methods: In this cross-sectional study, demographic data and serum CHIT1 activity in patients with BPD (n=21) and in healthy
controls (n=19) were compared. According to therapy, BPD patients were divided into two groups: inhaled steroid-free (n=13) and inhaled steroidpositive
(n=8), and all the aforementioned data were compared between these two groups also.
Results: In the comparison of laboratory parameters, no significant differences were in C-reactive protein (CRP), albumin and CRP/albumin ratio
(CAR) between healthy group and BPD group. While higher CHIT1 activity was detected in BPD group [16.4±13.0 nmol/mL/h] compared to healthy group [12.1±8.3 nmol/mL/h], this difference was not statistically significant. (p=0.456). On the other hand, CHIT1 activity was significantly higher
in inhaled steroid-free BPD patients (p=0.025) than inhaled steroid-positive ones. There was a positive correlation between ages and serum CHIT1
(r=0.26, p=0.025) in all subjects. On the other hand, in the correlation analysis of laboratory parameters, there was no correlation between CHIT1
level and CRP, albumin and CAR in all subjects.

Conclusion: Although this study provided some evidence that inhaled steroid treatment might decrease serum CHIT1 activity in BPD, further studies
with more patients are necessary.

Keywords

Bronchopulmonary Dysplasia , Chitotriosidase Activity , Inflammation

Ethical Statement

Ethical approval was obtained from Ankara University Clinical Research Ethics Committee (Approval no: 21.311.17, Date: 25.12.2017).

Supporting Institution

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Project Number

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Bronkopulmoner Displazide Serum Kitotriozidaz Aktivitesi: Kesitsel Bir Çalışma

Abstract

Amaç: Serum kitotriozidaz (CHIT1), hava yolu ve akciğer hastalıkları dahil olmak üzere enflamatuvar hastalıklarda kullanılan yeni bir biyobelirteçtir.
Bugüne kadar, bronkopulmoner displazi (BPD) hastalarında enflamasyonu belirlemek için serum CHIT1 aktivitesini değerlendiren bir çalışma yoktur.
Bu çalışmanın amacı, serum CHIT1 aktivitesinin BPD hastalarında enflamasyonu belirlemede yararlı bir belirteç olup olmadığını araştırmaktır.

Gereç ve Yöntem: Bu kesitsel çalışmada, BPD’li hastalarda (n=21) ve sağlıklı kontrollerde (n=19) demografik veriler ve serum CHIT1 aktivitesi
karşılaştırıldı. Tedaviye göre BPD hastaları inhale steroid tedavisi almayan (n=13) ve inhale steroid tedavisi alan (n=8) olmak üzere iki gruba ayrıldı
ve yukarıda belirtilen tüm veriler bu iki grup arasında da karşılaştırıldı.

Bulgular: Laboratuvar parametrelerinin karşılaştırılmasında, sağlıklı grup ile BPD grubu arasında C-reaktif protein (CRP), albümin ve CRP/albümin
oranı (CAO) açısından anlamlı fark bulunmadı. BPD grubunda [16,4±13,0 nmol/mL/h] sağlıklı gruba [12,1±8,3 nmol/mL/h] göre daha yüksek CHIT1
aktivitesi saptanırken, bu fark istatistiksel olarak anlamlı değildi (p=0,456). Öte yandan, inhale steroid içermeyen BPD hastalarında CHIT1 aktivitesi
inhale steroid tedavisi alanlara göre anlamlı olarak daha yüksekti (p=0,025). Tüm çalışma popülasyonunda yaş ile serum CHIT1 (r=0,26, p=0,025)
arasında pozitif bir korelasyon vardı. Öte yandan laboratuvar parametrelerinin korelasyon analizinde tüm çalışma popülasyonunda CHIT1 düzeyi ile
CRP, albümin ve CAO arasında anlamlı bir ilişki yoktu.

Sonuç: Bu çalışma, inhale steroid tedavisinin BPD’de serum CHIT1 aktivitesini azaltabileceğine dair bazı kanıtlar sağlasa da, daha fazla hasta içeren
ileri çalışmalara ihtiyaç vardır.

Keywords

Bronkopulmoner Displazi , Kitotriozidaz Aktivitesi , enflamasyon

Ethical Statement

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Supporting Institution

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Project Number

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Thanks

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