The Role of Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Red Cell Distribution Width as Inflammatory Markers in Brucellosis

Year 2022, Volume: 75 Issue: 4, 508 - 514, 20.01.2023

Ezgi Gülten , Sengül Üçer , Sümeyye Kazancıoğlu

Abstract

Objectives: Brucellosis is a zoonotic infectious disease. C-reactive protein (CRP) is widely used in the diagnosis, treatment and follow-up of
brucellosis. However, CRP is not a specific test. In this study, it is aimed to investigate the role of neutrophil to lymphocyte ratio (NLR), platelet to
lymphocyte ratio and red cell distribution width (RDW) as inflammatory markers in brucellosis.

Materials and Methods: In our study, ≥18 year old brucellosis patients followed between January 1st, 2017 and January 1st, 2019 were included.
Patients’ data were obtained through hospital information systems. Initial and monthly consecutive values of neutrophil counts, lymphocyte counts, platelet counts, RDW and CRP levels were recorded.

Results: One hundredand thirty-six patients were included in the study. 63.2% (n=86) of the cases were male. It was determined that Brucella
spp. was cultured in 7.4% of the patients’ samples. The patients were given antibacterial treatment during the median period of 7 (6-40) weeks. Under treatment, CRP and NLR declined significantly (p<0.05). At the end of the first and second months, RDW declined significantly but the same association could not be detected at the end of the third month (p=0.059). It was found that only NLR was correlated with CRP levels and its declining trend (p<0.05).

Conclusion: It is concluded that the values of NLR and RDW are useful to monitor treatment response in brucellosis patients. These values provide advantage since they can speedily be measured via automated complete blood count analyzer with no necessity for additional cost and human capital.

Keywords

Neutrophil To Lymphocyte Ratio , Platelet To Lymphocyte Ratio , Red Cell Distribution Width , Brucellosis , Inflammatory Markers In Brucellosis

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Bruselloz Olgularında Nötrofil Lenfosit Oranı, Platelet Lenfosit Oranı ve Eritrosit Dağılım Genişliğinin Enflamasyon Göstergesi Olarak Rolü

Abstract

Amaç: Bruselloz zoonotik bir enfeksiyon hastalığıdır. C-reaktif protein (CRP) bruselloz tanı ve tedavi takibinde yaygın bir biçimde kullanılmaktadır. Ancak, CRP özgül bir test değildir. Bu çalışmada nötrofil lenfosit oranı (NLO), platelet lenfosit oranı ve eritrosit dağılım genişliğinin (RDW) brusellozda enflamasyon göstergesi olarak rolünün araştırılması amaçlanmıştır.

Gereç ve Yöntem: Çalışmamıza 1 Ocak 2017 ve 1 Ocak 2019 tarihleri arasında takip edilen ≥18 yaş ve üzeri bruselloz hastaları dahil edildi. Hastaların verileri hastane bilgi sistemleri vasıtasıyla elde edildi. Başlangıç ve aylık ardışık nötrofil, lenfosit ve platelet sayıları, RDW ve CRP değerleri kaydedildi.

Bulgular: Çalışmaya 136 hasta dahil edildi. Olguların %63,2’si (n=86) erkekti. Hastaların %7,4’ünde kültürde Brucella spp. ürediği saptandı. Hastalara ortanca 7 (6-40) hafta süreyle antibakteriyel tedavi verildi. CRP ve NLO tedavi altında anlamlı biçimde geriledi (p<0,05). RDW birinci ve ikinci ay sonunda anlamlı değişiklik göstermekteyken (p<0,05), aynı ilişki üçüncü ay sonunda saptanamadı (p=0,059). CRP değerleri ve değişimiyle yalnız NLO ve değişimi arasında anlamlı korelasyon bulundu (p<0,05).

Sonuç: Bruselloz olgularında NLO ve RDW değerlerinin tedavi yanıtının izleminde yararlı olduğu sonucuna varılmıştır. Bu değerler otomatize tam
kan sayımıyla, hızlı bir şekilde ve ek maliyet ve iş gücü gerekmeksizin ölçülebildiğinden avantaj taşımaktadırlar.

Keywords

Nötrofil Lenfosit Oranı , Platelet Lenfosit Oranı , Eritrosit Dağılım Genişliği , Bruselloz , Brusellozda enflamasyon Göstergeleri

Ethical Statement

Çalışma için Balıkesir Üniversitesi Klinik Araştırmalar Etik Kurulu tarafından 10 Nisan 2019 tarihinde, 2019/62 karar numarasıyla onay alınmıştır

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