The Factors Affecting the Efficacy of Interleukin-1 Receptor Antagonists in COVID-19 Patients

Emine Uslu Yurteri; Volkan Alparslan; Mehmet Serindere; Mücteba Enes Yayla; Metin Eser; Leyla Batmaz; Dilşa Mizrak Kaya

doi:10.4274/atfm.galenos.2022.49354

The Factors Affecting the Efficacy of Interleukin-1 Receptor Antagonists in COVID-19 Patients

Abstract

Objectives: Coronavirus disease-2019 (COVID-19) spreads quickly all over the world. Interleukin-1 (IL-1) is a proinflammatory cytokine associated with SARS-CoV-2, causing lung damage. Anakinra is an IL-1 receptor antagonist. In this study, we aimed to describe the characteristics of COVID-19 patients who survived after anakinra treatment. Materials and Methods: Forty-four patients who did not respond to pulse steroid treatment and were given 8 mg/kg Anakinra were included in this study. The clinical, laboratory, and imaging [thorax computed tomography (CT)] findings of survivors and non-survivors who received anakinra treatment were compared. Results: Most of the patients were male (81.8%), the median follow-up period was 19.5 (IQR 15.5) days. Of the patients, 40.9% died. The median age was higher (p<0.001), and diabetes mellitus was more common (p<0.034) in non-survivors. In multivariate cox regression analysis, the presence of underlying hypertension (p=0.017) and pure ground glass opacity (GGO) on thorax CT at first admission to hospital (p=0.04) were found to be independent risk factors for mortality in COVID-19 patients treated with anakinra. Conclusion: The presence of hypertension in COVID-19 patients and the presence of pure GGO on thorax CT at first admission to the hospital are the findings that may reduce the response to anakinra treatment. Prospective studies with larger patient populations are needed to demonstrate the validity of this finding.

Keywords

Ethical Statement

Ethics Committee Approval: Mustafa Kemal University Faculty of Medicine, Clinical Research Ethics Committee approval was provided for the study (approval date/no: 4.2.2020-02). Informed Consent: Written informed consent for the off-label use of steroids and anakinra were obtained from all patients. Peer-reviewed: Externally peer-reviewed.

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Details

Primary Language

English

Subjects

Rheumatology and Arthritis

Journal Section

Research Article

Authors

Emine Uslu Yurteri ^*
0000-0002-4717-3000
Türkiye

Volkan Alparslan
0000-0002-7224-0578
Türkiye

Mehmet Serindere
0000-0003-1166-2467
Türkiye

Mücteba Enes Yayla
Türkiye

Metin Eser
0000-0002-5518-4383
Türkiye

Leyla Batmaz
0000-0002-0333-4765
Türkiye

Dilşa Mizrak Kaya This is me
0000-0002-3325-1178
Türkiye

Publication Date

October 18, 2022

Submission Date

January 25, 2022

Acceptance Date

August 26, 2022

Published in Issue

Year 2022 Volume: 75 Number: 3

DOI

https://doi.org/10.4274/atfm.galenos.2022.49354

IZ

https://izlik.org/JA57HA72YU

Cite

RIS / Bibtex

APA

Uslu Yurteri, E., Alparslan, V., Serindere, M., Yayla, M. E., Eser, M., Batmaz, L., & Mizrak Kaya, D. (2022). The Factors Affecting the Efficacy of Interleukin-1 Receptor Antagonists in COVID-19 Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 75(3), 400-405. https://doi.org/10.4274/atfm.galenos.2022.49354

AMA

1.Uslu Yurteri E, Alparslan V, Serindere M, et al. The Factors Affecting the Efficacy of Interleukin-1 Receptor Antagonists in COVID-19 Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2022;75(3):400-405. doi:10.4274/atfm.galenos.2022.49354

Chicago

Uslu Yurteri, Emine, Volkan Alparslan, Mehmet Serindere, et al. 2022. “The Factors Affecting the Efficacy of Interleukin-1 Receptor Antagonists in COVID-19 Patients”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 75 (3): 400-405. https://doi.org/10.4274/atfm.galenos.2022.49354.

EndNote

Uslu Yurteri E, Alparslan V, Serindere M, Yayla ME, Eser M, Batmaz L, Mizrak Kaya D (October 1, 2022) The Factors Affecting the Efficacy of Interleukin-1 Receptor Antagonists in COVID-19 Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası 75 3 400–405.

IEEE

[1]E. Uslu Yurteri et al., “The Factors Affecting the Efficacy of Interleukin-1 Receptor Antagonists in COVID-19 Patients”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 75, no. 3, pp. 400–405, Oct. 2022, doi: 10.4274/atfm.galenos.2022.49354.

ISNAD

Uslu Yurteri, Emine - Alparslan, Volkan - Serindere, Mehmet - Yayla, Mücteba Enes - Eser, Metin - Batmaz, Leyla - Mizrak Kaya, Dilşa. “The Factors Affecting the Efficacy of Interleukin-1 Receptor Antagonists in COVID-19 Patients”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 75/3 (October 1, 2022): 400-405. https://doi.org/10.4274/atfm.galenos.2022.49354.

JAMA

1.Uslu Yurteri E, Alparslan V, Serindere M, Yayla ME, Eser M, Batmaz L, Mizrak Kaya D. The Factors Affecting the Efficacy of Interleukin-1 Receptor Antagonists in COVID-19 Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2022;75:400–405.

MLA

Uslu Yurteri, Emine, et al. “The Factors Affecting the Efficacy of Interleukin-1 Receptor Antagonists in COVID-19 Patients”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 75, no. 3, Oct. 2022, pp. 400-5, doi:10.4274/atfm.galenos.2022.49354.

Vancouver

1.Emine Uslu Yurteri, Volkan Alparslan, Mehmet Serindere, Mücteba Enes Yayla, Metin Eser, Leyla Batmaz, Dilşa Mizrak Kaya. The Factors Affecting the Efficacy of Interleukin-1 Receptor Antagonists in COVID-19 Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2022 Oct. 1;75(3):400-5. doi:10.4274/atfm.galenos.2022.49354