In Vitro Fertilizasyon (IVF) Yapılan Polikistik Over Sendromlu Kadınların Gebelik Komplikasyonlarının Değerlendirilmesi
Abstract
Objectives: The aim of the study is to compare the pregnancy complications including particularly gestational diabetes mellitus (GDM) and
preeclampsia of women having polycystic ovarian syndrome (PCOS), with normal pregnancy complications.
Materials and Methods: To investigate the impact of PCOS on pregnancy complications, we retrospectively compared the pregnant patients
(diagnosed with PCOS) with normal pregnant patients who became pregnant using the intra cytoplasmic sperm injection method, having same
age and body mass index, at İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Obstetrics and Gynecology, In Vitro
Fertilization Unit between 2002 and 2011.
Results: When the patients diagnosed with PCOS and control group were compared in terms of the pregnancy complications, early pregnancy loss
and GDM were found to be statistically significant. (respectively p=0.005, p=0.013). The interaction between early pregnancy loss and gestational
diabetes with age, body mass index, gestational weight gain, fasting glucose, fasting insulin and Homeostasis Model Assessment (HOMA-IR) values
were investigated with the Spearman correlation analysis. While the gestational weight gain was negatively correlated with early pregnancy loss;
age, fasting glucose, fasting insulin and HOMA-IR were positively correlated with gestational diabetes (p=0.001 for early pregnancy loss; p=0.005,
p=0.001, p=0.005, p=0.001 respectively for GDM).
Conclusion: Early pregnancy loss and GDM are seen more often in polycystic ovary syndrome. Early pregnancy loss of pregnant women with PCOS
was found to be high independent of the blood sugar regulation parameters of the patients.
Keywords
Polycstic Ovarian Syndrome, GDM, Preeclampsia, Early Pregnancy Loss, Pregnancy Complications
Ethical Statement
Etik
Etik Kurul Onayı: İstanbul Üniversitesi-Cerrahpaşa,
Cerrahpaşa Tıp Fakültesi Etik Kurulu’ndan (tarih: 22.06.2012,
karar no: 3221) onay alınmıştır.
Hasta Onayı: Çalışmamız retrospektif olduğu için
hastalardan yazılı onam alınamamıştır.
Hakem Değerlendirmesi: Editörler kurulu dışında olan
kişiler tarafından değerlendirilmiştir.
References
- 1. Fauser BC, Tarlatzis BC, Rebar RW, et al. Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRMSponsored 3rd PCOS Consensus Workshop Group. Fertil Steril. 2012;97:28-38.
- 2. Rotterdam EA-SPCWG. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81:19-25.
- 3. Zeng X, Xie YJ, Liu YT, et al. Polycystic ovarian syndrome: Correlation between hyperandrogenism, insulin resistance and obesity. Clin Chim Acta. 2020;502:214-221.
- 4. González F, Considine RV, Abdelhadi OA, et al. Inflammation Triggered by Saturated Fat Ingestion Is Linked to Insulin Resistance and Hyperandrogenism in Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2020;105:2152-2167.
- 5. Wild RA. Long-term health consequences of PCOS. Hum Reprod Update. 2002;8:231-241.
- 6. Bannigida DM, Nayak BS, Vijayaraghavan R. Insulin resistance and oxidative marker in women with PCOS. Arch Physiol Biochem. 2020;126:183-186.
- 7. International Association of Diabetes and Pregnancy Study Groups Consensus Panel, Metzger BE, Gabbe SG, et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care. 2010;33:676-682.
- 8. Boomsma CM, Fauser BC, Macklon NS. Pregnancy complications in women with polycystic ovary syndrome. Semin Reprod Med. 2008;26:72-84.
- 9. Hatch R, Rosenfield RL, Kim MH, et al. Hirsutism: implications, etiology, and management. Am J Obstet Gynecol. 1981;140:815-830 . 10. Balen AH, Laven JS, Tan SL, et al. Ultrasound assessment of the polycystic ovary: international consensus definitions. Hum Reprod Update. 2003;9:505-514.
- 11. Heijnen EM, Eijkemans MJ, Hughes EG, et al. A meta-analysis of outcomes of conventional IVF in women with polycystic ovary syndrome. Hum Reprod Update. 2006;12:13-21.