Role of Liver Biopsy in the Diagnosis of Liver Diseases in Children
Abstract
Objectives: It was aimed to determine the diagnostic efficacy of liver biopsy with clinical and laboratory data by analyzing liver biopsies performed
in our center in terms of indication, clinical and laboratory data, pre-diagnosis and histopathological diagnoses.
Materials and Methods: The study was conducted by retrospectively examining demographic, physical examination, laboratory, ultrasonography
findings, biopsy indications and histopathological diagnosis information of patients aged 0-18 years, who underwent liver biopsy with neonatal
cholestasis, chronic liver disease, isolated hypertransaminasemia, isolated hepatomegaly and ultrasonographic parenchymal findings between 2008
and 2017. The patients were evaluated by dividing into two groups: those who underwent liver biopsy to confirm the pre-diagnosis (Group 1), and
those without pre-diagnosis and underwent biopsy for diagnostic purposes (Group 2).
Results: A total of 262 patients (mean age: 8.8±5.7 years, 53% male), including 183 (69.8%) in Group 1 and 79 (30.2%) in Group 2, were included.
The definitive diagnosis was reached in 87.4% and 26.6% in two groups, respectively. Presence of pre-diagnosis (p=0.001), hepatomegaly (p=0.001),
splenomegaly (p=0.001) on physical examination and detection of liver parenchymal pathology with ultrasonography (p=0.008) were found to be
statistically significant in obtaining a definitive diagnosis with biopsy.
Keywords
Biopsy, Liver, Child, Pre-diagnosis, Histopathological Diagnosis
Ethical Statement
Etik Kurul Onayı: 24.07.2017’de Ankara Üniversitesi Tıp
Fakültesi Klinik Araştırmalar Etik Kurulu’ndan 12-740-17 karar
numaralı etik onay alınmıştır.
Hasta Onayı: Retrospektif çalışmadır.
Hakem Değerlendirmesi: Editörler kurulunun dışından olan
kişiler tarafından değerlendirilmiştir.
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