History of Vaccines and New Vaccine Strategies

Selin Gamze Kılıç; İştar Dolapçı

doi:10.4274/atfm.galenos.2020.14227

EN TR

History of Vaccines and New Vaccine Strategies

Abstract

Edward Jenner’s invention of vaccination in 1796 has been considered as one of the greatest accomplishments in the history of medicine and vaccination currently prevents 2 to 3 million deaths every year. Despite this, more than 1,5 million people worldwide die from vaccine-preventable diseases each year. In today’s increasingly mobile lifestyle, infectious diseases know no boundaries. The most recent example to this is the fact that severe acute respiratory syndrome coronavirus-2 which originated in Wuhan, China has become the reason of a global pandemic in a very short time. As well as these and similar infectious diseases that have emerged and have not yet been vaccinated, there are other infectious diseases that existing vaccine technologies cannot prevent despite their undeniable success and constitute a large share of mortality worldwide. Versatile vaccine development studies are being done against these diseases and fields of new delivery platforms, new adjuvants, new approaches in antigen presentation and new stable and efficient antigen production are being focused on. In this review, firstly, the developmental history of vaccine is mentioned briefly and new designs and technologies, distribution platforms and application methods in vaccine studies are explained. Key Words: Vaccine, Vaccination, Vaccine Strategies, Vaccine Types

Keywords

Vaccine, Vaccination, Vaccine Strategies, Vaccine Types

Aşıların Tarihçesi ve Yeni Aşı Stratejileri

Abstract

1796 yılında Edward Jenner ile başlayan aşı serüveni, tıp tarihinin en büyük küresel başarılarından biri olarak kabul edilmekte ve günümüzde her yıl aşılama ile 2-3 milyon insanın hayatı kurtarılmaktadır. Bu gerçeğe rağmen yine her yıl tüm dünyada 1,5 milyondan fazla insan aşı ile önlenebilir hastalıklar yüzünden kaybedilmektedir. Günümüzde uluslararası hareketliliğin artışının bir getirisi olarak enfeksiyon hastalıkları sınır tanımamaktadır. Tüm dünya buna en son 2019 yılının sonunda Çin’in Wuhan kentinde ortaya çıkan şiddetli akut solunum sendromu koronavirüs-2 salgının kısa bir süre içerisinde pandemiye dönüşmesi ile tanık olmuştur. Bu ve benzeri yeni ortaya çıkan ve henüz aşısı olmayan enfeksiyon hastalıkları olduğu gibi, yadsınamaz başarılarına rağmen mevcut aşı teknolojilerinin önleyemediği ve dünya genelinde mortalitenin büyük payını oluşturan başka enfeksiyon hastalıkları da bulunmaktadır. Bu hastalıklara karşı çok yönlü aşı geliştirme çalışmaları sürdürülmekte ve temel olarak yeni dağıtım platformları, yeni adjuvanlar, antijen sunumunda yeni yaklaşımlar ve yeni kararlı, etkin antijen üretimi alanlarına yoğunlaşılmaktadır. Bu derlemede öncelikle aşının tarih boyunca gelişiminden kısaca bahsedilecek daha sonra aşı çalışmalarında yer alan yeni tasarım/teknolojilere, dağıtım platformlarına ve uygulama yollarına değinilecektir. Anahtar Kelimeler: Aşı, Aşılama, Aşı Stratejileri, Aşı Türleri

Keywords

Aşı, Aşılama, Aşı Stratejileri, Aşı Türleri

Ethical Statement

Hakem Değerlendirmesi: Editörler kurulunun içinden ve dışından olan kişiler tarafından değerlendirilmiştir. Yazarlık Katkıları Konsept: S.G.K., İ.D., Dizayn: S.G.K., İ.D., Veri Toplama veya İşleme: S.G.K., İ.D., Analiz veya Yorumlama: S.G.K., İ.D., Literatür Arama: S.G.K., İ.D., Yazan: S.G.K., İ.D. Finansal Destek: Yazarlar tarafından finansal destek almadıkları bildirilmiştir.

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Details

Primary Language

English

Subjects

Medical Microbiology (Other)

Journal Section

Review

Authors

Selin Gamze Kılıç ^* This is me
0000-0002-2747-7293
Türkiye

İştar Dolapçı
0000-0002-6443-4612
Türkiye

Publication Date

April 30, 2021

Submission Date

September 3, 2020

Acceptance Date

November 30, 2020

Published in Issue

Year 2021 Volume: 74 Number: 1

DOI

https://doi.org/10.4274/atfm.galenos.2020.14227

IZ

https://izlik.org/JA82ZM55LT

APA

Kılıç, S. G., & Dolapçı, İ. (2021). History of Vaccines and New Vaccine Strategies. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 74(1), 1-10. https://doi.org/10.4274/atfm.galenos.2020.14227

AMA

1.Kılıç SG, Dolapçı İ. History of Vaccines and New Vaccine Strategies. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2021;74(1):1-10. doi:10.4274/atfm.galenos.2020.14227

Chicago

Kılıç, Selin Gamze, and İştar Dolapçı. 2021. “History of Vaccines and New Vaccine Strategies”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 74 (1): 1-10. https://doi.org/10.4274/atfm.galenos.2020.14227.

EndNote

Kılıç SG, Dolapçı İ (April 1, 2021) History of Vaccines and New Vaccine Strategies. Ankara Üniversitesi Tıp Fakültesi Mecmuası 74 1 1–10.

IEEE

[1]S. G. Kılıç and İ. Dolapçı, “History of Vaccines and New Vaccine Strategies”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 74, no. 1, pp. 1–10, Apr. 2021, doi: 10.4274/atfm.galenos.2020.14227.

ISNAD

Kılıç, Selin Gamze - Dolapçı, İştar. “History of Vaccines and New Vaccine Strategies”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 74/1 (April 1, 2021): 1-10. https://doi.org/10.4274/atfm.galenos.2020.14227.

JAMA

1.Kılıç SG, Dolapçı İ. History of Vaccines and New Vaccine Strategies. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2021;74:1–10.

MLA

Kılıç, Selin Gamze, and İştar Dolapçı. “History of Vaccines and New Vaccine Strategies”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 74, no. 1, Apr. 2021, pp. 1-10, doi:10.4274/atfm.galenos.2020.14227.

Vancouver

1.Selin Gamze Kılıç, İştar Dolapçı. History of Vaccines and New Vaccine Strategies. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2021 Apr. 1;74(1):1-10. doi:10.4274/atfm.galenos.2020.14227

History of Vaccines and New Vaccine Strategies

Abstract

Keywords

Aşıların Tarihçesi ve Yeni Aşı Stratejileri

Abstract

Keywords

Ethical Statement

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite