Is There a Difference in Anxiety, Body Perception, and Depression Scales According to Subphenotypes of Polycystic Ovary Syndrome?

Year 2021, Volume: 74 Issue: 1, 38 - 42, 30.04.2021

Asena Gökçay Canpolat , Özgür Demir , Merve Sema Sert Betül Yarsan Züleyha Tekfidan Şeyma Nur Yaman Esmanur Oğuz Ela Gazal Hande Hatice Şimşek Tuğba Altun Ensari , Demet Çorapçıoğlu

Abstract

Objectives: Polycystic ovary syndrome (PCOS) is the most prevalent female reproductive disorder. PCOS is associated with increased mood disorders. We aimed to evaluate the association between PCOS sub-phenotypes and anxiety, body perception, and depression scales in our study.

Materials and Methods: We enrolled 74 patients with PCOS and we assigned them into subphenotypes of PCOS. The Beck depression inventory (BDI-II) was used for depression, the Beck anxiety inventory (BAI) was used for anxiety, and the body esteem scale (BES) was used to assess body perception for all participants.

Results: The BDI-II scores of phenotype A were higher than phenotype D. The BAI scores of phenotype A were higher than phenotype B, C, and D. There was no difference between BES scores through all PCOS phenotypes. There was a difference in modified Ferriman-Gallwey score between phenotypes except between phenotype A and phenotype B (p=0.13). An increase in BMI by 1 kg/m2 was found to cause a 0.49 increase in depression scores (p=0.01) but there was no association between BMI and BAI and BES scores (p=0.33, p=0.18).

Conclusion: PCOS is associated with mood disorders, especially anxiety and depression. Until now, there was no information about the prevalence of mood disturbances according to subphenotypes of PCOS. The higher prevalence of depression was seen in phenotype A than phenotype D but it was similar among A, B, and C. It has suggested that hyperandrogenism may have a causative effect on pathogenesis of depression in women with PCOS. The higher BAI scores were recorded in phenotype A than phenotype B, C, and D, and BES scores were similar through phenotypes. Although we could not find a close phenotype-mood disorder association, we believe the need for screening for mood disorders, especially anxiety and depression, for patients with PCOS because of the importance of the disease’s psychological consequences.

Key Words: PCOS Phenotypes, Depression, Anxiety, Body Perception, Modified Ferriman-Gallwey Score

Keywords

PCOS Phenotypes , Depression , Anxiety , Body Perception , Modified Ferriman-Gallwey Score

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Polikistik Over Sendrom Fenotipleri Arasında Depresyon, Anksiyete ve Beden Algısı Ölçekleri Açısından Farklılık Var Mıdır?

Abstract

Amaç: Polikistik over sendromu (PKOS), en yaygın kadın üreme bozukluğudur. PKOS duygudurum bozuklukları ile ilişkilidir. Çalışmamızda PKOS alt fenotipleri ile anksiyete, beden algısı ve depresyon ölçekleri arasındaki ilişkiyi değerlendirmeyi amaçladık.

Gereç ve Yöntem: Çalışmaya PKOS’li 74 hasta dahil edilmiş ve PKOS’nin alt fenotiplerine ayrılmıştır. Tüm katılımcılara depresyon için Beck depresyon envanteri (BDI-II), anksiyete için Beck anksiyete envanteri (BAE) ve beden algısını değerlendirmek için beden saygısı ölçeği (BES) kullanıldı.

Bulgular: Fenotip A’nın BDI-II skorları, fenotip D’den daha yüksekti. Fenotip A’nın BAI skorları, fenotip B,C ve D’den yüksekti. BES skorları açısından tüm fenotipler açısından fark yoktu. Fenotip A ve fenotip B dışında (p=0,13), fenotipler arasında Ferriman-Gallway skorları açısından fark yoktu. BKİ’deki her 1 kg/m2 artışın, depresyon skorlarında 0,49 artışa neden olduğu, ancak BKİ, BAI ve BES skorları arasında ilişki bulunmadığı tespit edildi (p=0,33, p=0,18).

Sonuç: PKOS duygudurum bozuklukları ile ve özellikle anksiyete ve depresyon ile ilişkilidir. Şimdiye kadar, PKOS alt fenotiplerine göre duygudurum bozukluklarının yaygınlığı hakkında bilgi bulunmamaktadır. Fenotip A’da, fenotip D’ye göre daha yüksek depresyon prevalansı görülmüş, ancak A, B ve C arasında benzerlik görülmüştür. Bu durum, PKOS’li kadınlarda hiperandrojenizmin depresyon patogenezinde nedensel bir etkiye sahip olabileceğini düşündürmüştür. Fenotip A’da, fenotip B, C ve D’ye oranla daha yüksek BAI skorları tespit edilmiş, ancak BES skorları tüm gruplarda benzer bulunmuştur. Fenotip-duygudurum bozukluğu ilişkisi özgül olarak bulunamamış olsa da, hastalığın psikolojik sonuçlarının önemi nedeniyle PKOS’li hastalarda duygudurum bozukluklarının, özellikle anksiyete ve depresyonun taranması gerektiğine inanıyoruz.

Anahtar Kelimeler: PKOS Alt Fenotipleri, Depresyon, Anksiyete, Beden Algısı, Modifiye Ferriman Gallway Skoru

Keywords

PKOS Alt Fenotipleri , Depresyon , Anksiyete , Beden Algısı , Modifiye Ferriman Gallway Skoru

Ethical Statement

Ethics Committee Approval: This study was approved by Ankara University Faculty of Medicine Undergraduate Student Research Ethics Review Board (date: 25.12.2018, decision no: 9530). Informed Consent: All subjects signed informed consent forms. Peer-review: Externally and internally peer-reviewed. Authorship Contributions Surgical and Medical Practices: T.A.E., Concept: D.Ç., Design: Ö.D., Data Collection or Processing: M.S.S., B.Y., Z.T., Ş.N.Y., E.O., E.G., H.H.Ş., Analysis or Interpretation: M.S.S., B.Y., Z.T., Ş.N.Y., E.O., E.G., H.H.Ş., Literature Search: A.G.C., Writing: A.G.C. Conflict of Interest: No conflict of interest was declared by the authors. Financial Disclosure: The authors declared that this study received no financial support.

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