Research Article
BibTex RIS Cite

Analysis of Patients with Intrathoracic Placement Schwannoma Pathological Diagnosis, Single Center Experience

Year 2020, Volume: 73 Issue: 2, 135 - 138, 31.08.2020
https://izlik.org/JA47ND23XA

Abstract

Objectives: The origin of neurilemmoma is Schwann cells and it is the most frequent subgroup of neurogenic tumors. It is often detected in the 3rd-5th decades. The region is located in the posterior mediastinum. Recurrence rates are very low when surgically resected. In this study, this type of tumor resected in our clinic was analyzed and evaluated with the literature.

Materials and Methods: Twenty-five patients diagnosed with Schwannoma resected between January 2008 and January 2018 in Ankara University Faculty of Medicine, Department of Thoracic Surgery were retrospectively reviewed. All preoperative patients were evaluated by thoracic computed tomography. In case of suspicion of invasion into the spinal canal, magnetic resonance imaging was used.

Results: Of all the patients included in the study, 14 (56%) were male and 11 (44%) were female. The mean age was 47±12.6 (31-66) years. The main symptom in the patients was back pain. It was determined that the lesions were frequently located in the paravertebral sulcus. 56% of Schwannoma masses were observed in the right and 44% in the left hemithorax. For resection, 18 patients underwent muscle sparing thoracotomy, six patients underwent video-assisted thoracoscopic surgery, and one patient underwent a median sternotomy procedure.

Conclusion: The most common type of neurogenic tumors originating from neural cells is neurilemmomas originating from Schwann cells. It is generally located in the posterior mediastinum. They are asymptomatic between the rates of 40% and 60%. In our patients, the rate of symptomatic patients was higher. Recurrence is very low in patients undergoing resection in Schwannoma

Ethical Statement

Çalışma geriye dönük analiz olduğundan dolayı etik kurul onayı alınmamıştır

Supporting Institution

-

Project Number

-

Thanks

-

References

  • 1. Ida CM, Scheithauer BW, Yapıcıer Ö, et al. Primary schwannoma of the bone: A clinicopathologic and radiologic study of 17 cases. Am J Surg Pathol. 2011;35:989-997.
  • 2. Kurtkaya-Yapicier Ö, Scheithauer BW, Woodruff JM, et al. Schwannoma with rhabdomyoblastic differentiation: A unique variant of Malignant Triton Tumor. 2003;27:848-853.
  • 3. Meis-Kindblom JM, Enzinger FM. Plexiform malignant peripheral nerve sheath tumor of infancy and childhood. Am J Surg Pathol. 1994;18:479- 485.
  • 4. Miettinen M, Shekitka KM, Sobin LH. Schwannomas in the Colon and Rectum. A Clinicopathologic and Immunohistochemical Study of 20 Cases. 2001;25:846-855.
  • 5. Topçu S, Alper A, Gülhan E, et al. Neurogenic tumours of the mediastinum: a report of 60 cases. Can Respir J. 2000;7:261-265.
  • 6. Yamaguchi M, Yoshino I, Fukuyama S, et al. Surgical treatment of neurogenic tumors of the chest. Ann Thorac Cardiovasc Surg. 2004;10:148-151.
  • 7. Strollo DC, Rosado-de-Christenson ML, Jett JR. Primary mediastinal tumors: part II. Tumors of the middle and posterior mediastinum. Chest. 1997;112:1344-1357.
  • 8. Endo S, Murayama F, Otani S, et al. Alternative surgical approaches for apical neurinomas: a thoracoscopic approach. Ann Thorac Surg. 2005;80:295-298.
  • 9. Ohtsuka T, Nomori H, Naruke T, et al. Intrapulmonary schwannoma. Jpn J Thorac Cardiovasc Surg. 2005;53:154-156.
  • 10. Lin YF, Hsi SC, Chang JL, et al. Intrapulmonary psammomatous melanotic schwannoma. J Thorac Cardiovasc Surg. 2009;137:25-27.
  • 11. Rammos KS, Foroulis CN, Zaramboukas TK, et al. Schwannoma of the vagus nerve, a rare middle mediastinal neurogenic tumor: case report. J Cardiothorac Surg. 2009;4:68.
  • 12. Stouffer CW, Allan RW, Shillingford MS, et al. Endobronchial schwannoma presenting with bronchial obstruction. Interact Cardiovasc Thorac Surg. 2010;10:133-134.
  • 13. Kasahara K, Fukuoka K, Konishi M, et al. Two cases of endobronchial neurilemmoma and review of the literature in Japan. Intern Med. 2003;42:1215-1218.
  • 14. Heitmiller RF, Labs JD, Lipsett PA. Vagal schwannoma. Ann Thorac Surg 1990;50:811-813.
  • 15. Ayub S, Shakoor MT, Hasan S, et al. Mediastinal mass diagnosed as a benign schwannoma. Singapore Med J. 2011;52:e167-e169.
  • 16. AndersenDB, Kamp S, Madelung A, et al. Unilateral hyperhidrosis and hypothermia: symptoms of an intrathoracic tumour. British Journal of Dermatology. 2015;74:1147-1148.
  • 17. Kato M, Shioata S, Shiga K, et al. Benign Giant Mediastinal Schwannoma Presenting as Cardiac Tamponade in a Woman: A Case Report. J Med Case Rep. 2011;14:5:61.
  • 18. Kitamura Y, Sakakura N, Uchida T, et al. Neurinoma Arising From Brachial Plexus With Intrathoracic Extension Resected Through the Second Intercostal Space. Kyobu Geka. 2010;63:1133-1135.
  • 19. Gossot D, Izquierdo RR, Girard P, Stern JB, Magdeleinat P. Thoracoscopic resection of bulky intrathoracic benign lesions. Eur J Cardiothorac Surg. 2007;32:848-851.
  • 20. Kan P, Schmidt MH. Minimally invasive thoracoscopic resection of paraspinal neurogenic tumors: technical case report. Neurosurgery. 2008;63:54.
  • 21. Yamaguchi M, Yoshino I, Kameyama T, et al. Thoracoscopic surgery combined with a supraclavicular approach for removing a cervicomediastinal neurogenic tumor: a case report. Ann Thorac Cardiovasc Surg. 2006;12:194-196.
  • 22. Endo S, Murayama F, Otani S, et al. Alternative surgical approaches for apical neurinomas: a thoracoscopic approach. Ann Thorac Surg. 2005;80:295-298.
  • 23. Landreneau RJ, Dowling RD, Ferson PF. Thoracoscopic resection of a posterior mediastinal neurogenic tumor. Chest. 1992;102:1288-1290.
  • 24. Sakumoto N, Inafuku S, Shimoji H, et al. Videothoracoscopic surgery for thoracic neurogenic tumors: a 7-year experience. Surg Today. 2000;30:974- 977.

İntratorasik Yerleşimli Schwannoma Patolojik Tanılı Hastaların Analizi, Tek Merkez Deneyimi

Year 2020, Volume: 73 Issue: 2, 135 - 138, 31.08.2020
https://izlik.org/JA47ND23XA

Abstract

Project Number

-

References

  • 1. Ida CM, Scheithauer BW, Yapıcıer Ö, et al. Primary schwannoma of the bone: A clinicopathologic and radiologic study of 17 cases. Am J Surg Pathol. 2011;35:989-997.
  • 2. Kurtkaya-Yapicier Ö, Scheithauer BW, Woodruff JM, et al. Schwannoma with rhabdomyoblastic differentiation: A unique variant of Malignant Triton Tumor. 2003;27:848-853.
  • 3. Meis-Kindblom JM, Enzinger FM. Plexiform malignant peripheral nerve sheath tumor of infancy and childhood. Am J Surg Pathol. 1994;18:479- 485.
  • 4. Miettinen M, Shekitka KM, Sobin LH. Schwannomas in the Colon and Rectum. A Clinicopathologic and Immunohistochemical Study of 20 Cases. 2001;25:846-855.
  • 5. Topçu S, Alper A, Gülhan E, et al. Neurogenic tumours of the mediastinum: a report of 60 cases. Can Respir J. 2000;7:261-265.
  • 6. Yamaguchi M, Yoshino I, Fukuyama S, et al. Surgical treatment of neurogenic tumors of the chest. Ann Thorac Cardiovasc Surg. 2004;10:148-151.
  • 7. Strollo DC, Rosado-de-Christenson ML, Jett JR. Primary mediastinal tumors: part II. Tumors of the middle and posterior mediastinum. Chest. 1997;112:1344-1357.
  • 8. Endo S, Murayama F, Otani S, et al. Alternative surgical approaches for apical neurinomas: a thoracoscopic approach. Ann Thorac Surg. 2005;80:295-298.
  • 9. Ohtsuka T, Nomori H, Naruke T, et al. Intrapulmonary schwannoma. Jpn J Thorac Cardiovasc Surg. 2005;53:154-156.
  • 10. Lin YF, Hsi SC, Chang JL, et al. Intrapulmonary psammomatous melanotic schwannoma. J Thorac Cardiovasc Surg. 2009;137:25-27.
  • 11. Rammos KS, Foroulis CN, Zaramboukas TK, et al. Schwannoma of the vagus nerve, a rare middle mediastinal neurogenic tumor: case report. J Cardiothorac Surg. 2009;4:68.
  • 12. Stouffer CW, Allan RW, Shillingford MS, et al. Endobronchial schwannoma presenting with bronchial obstruction. Interact Cardiovasc Thorac Surg. 2010;10:133-134.
  • 13. Kasahara K, Fukuoka K, Konishi M, et al. Two cases of endobronchial neurilemmoma and review of the literature in Japan. Intern Med. 2003;42:1215-1218.
  • 14. Heitmiller RF, Labs JD, Lipsett PA. Vagal schwannoma. Ann Thorac Surg 1990;50:811-813.
  • 15. Ayub S, Shakoor MT, Hasan S, et al. Mediastinal mass diagnosed as a benign schwannoma. Singapore Med J. 2011;52:e167-e169.
  • 16. AndersenDB, Kamp S, Madelung A, et al. Unilateral hyperhidrosis and hypothermia: symptoms of an intrathoracic tumour. British Journal of Dermatology. 2015;74:1147-1148.
  • 17. Kato M, Shioata S, Shiga K, et al. Benign Giant Mediastinal Schwannoma Presenting as Cardiac Tamponade in a Woman: A Case Report. J Med Case Rep. 2011;14:5:61.
  • 18. Kitamura Y, Sakakura N, Uchida T, et al. Neurinoma Arising From Brachial Plexus With Intrathoracic Extension Resected Through the Second Intercostal Space. Kyobu Geka. 2010;63:1133-1135.
  • 19. Gossot D, Izquierdo RR, Girard P, Stern JB, Magdeleinat P. Thoracoscopic resection of bulky intrathoracic benign lesions. Eur J Cardiothorac Surg. 2007;32:848-851.
  • 20. Kan P, Schmidt MH. Minimally invasive thoracoscopic resection of paraspinal neurogenic tumors: technical case report. Neurosurgery. 2008;63:54.
  • 21. Yamaguchi M, Yoshino I, Kameyama T, et al. Thoracoscopic surgery combined with a supraclavicular approach for removing a cervicomediastinal neurogenic tumor: a case report. Ann Thorac Cardiovasc Surg. 2006;12:194-196.
  • 22. Endo S, Murayama F, Otani S, et al. Alternative surgical approaches for apical neurinomas: a thoracoscopic approach. Ann Thorac Surg. 2005;80:295-298.
  • 23. Landreneau RJ, Dowling RD, Ferson PF. Thoracoscopic resection of a posterior mediastinal neurogenic tumor. Chest. 1992;102:1288-1290.
  • 24. Sakumoto N, Inafuku S, Shimoji H, et al. Videothoracoscopic surgery for thoracic neurogenic tumors: a 7-year experience. Surg Today. 2000;30:974- 977.
There are 24 citations in total.

Details

Primary Language English
Subjects Thoracic Surgery
Journal Section Research Article
Authors

Bülent Mustafa Yenigün 0000-0001-6543-5441

Project Number -
Publication Date August 31, 2020
DOI https://doi.org/10.4274/atfm.galenos.2020.20438
IZ https://izlik.org/JA47ND23XA
Published in Issue Year 2020 Volume: 73 Issue: 2

Cite

APA Yenigün, B. M. (2020). Analysis of Patients with Intrathoracic Placement Schwannoma Pathological Diagnosis, Single Center Experience. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 73(2), 135-138. https://doi.org/10.4274/atfm.galenos.2020.20438
AMA 1.Yenigün BM. Analysis of Patients with Intrathoracic Placement Schwannoma Pathological Diagnosis, Single Center Experience. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2020;73(2):135-138. doi:10.4274/atfm.galenos.2020.20438
Chicago Yenigün, Bülent Mustafa. 2020. “Analysis of Patients With Intrathoracic Placement Schwannoma Pathological Diagnosis, Single Center Experience”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 73 (2): 135-38. https://doi.org/10.4274/atfm.galenos.2020.20438.
EndNote Yenigün BM (August 1, 2020) Analysis of Patients with Intrathoracic Placement Schwannoma Pathological Diagnosis, Single Center Experience. Ankara Üniversitesi Tıp Fakültesi Mecmuası 73 2 135–138.
IEEE [1]B. M. Yenigün, “Analysis of Patients with Intrathoracic Placement Schwannoma Pathological Diagnosis, Single Center Experience”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 73, no. 2, pp. 135–138, Aug. 2020, doi: 10.4274/atfm.galenos.2020.20438.
ISNAD Yenigün, Bülent Mustafa. “Analysis of Patients With Intrathoracic Placement Schwannoma Pathological Diagnosis, Single Center Experience”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 73/2 (August 1, 2020): 135-138. https://doi.org/10.4274/atfm.galenos.2020.20438.
JAMA 1.Yenigün BM. Analysis of Patients with Intrathoracic Placement Schwannoma Pathological Diagnosis, Single Center Experience. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2020;73:135–138.
MLA Yenigün, Bülent Mustafa. “Analysis of Patients With Intrathoracic Placement Schwannoma Pathological Diagnosis, Single Center Experience”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 73, no. 2, Aug. 2020, pp. 135-8, doi:10.4274/atfm.galenos.2020.20438.
Vancouver 1.Bülent Mustafa Yenigün. Analysis of Patients with Intrathoracic Placement Schwannoma Pathological Diagnosis, Single Center Experience. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2020 Aug. 1;73(2):135-8. doi:10.4274/atfm.galenos.2020.20438