Increased Galectin-3 Levels Predicts Ventricular Arrhythmic Events Following ST-elevation Myocardial İnfarction

Abstract

Objectives: We aimed to determine the association between Galectin-3 (Gal-3) levels and microvolt T-wave alternans (MTWA) and frequent premature ventricular complexes (PVCs) in single-vessel patients with left ventricular ejection fraction (EF) (LVEF) >35%, who presented with STelevated myocardial infarction (MI) (STEMI) and were treated with primary percutane-ous coronary intervention (pPCI). Materials and Methods: A total of 81 patients were included in this cross-sectional study. Blood samples for Gal-3 levels were obtained from all patients at the time of admission. The patients were separated into low and high Gal-3 (≤ and >1.93 ng/dL, respectively) groups. Low-Gal-3 and high-Gal-3 groups were compared with respect to both MTWA and PVC positivity and their association with Gal-3 levels were examined. Results: When compared to the low-Gal-3 group, left atrial volume (LAV) was higher in the high-Gal-3 patients (55.7±18.0 vs 40.6±13.7 mL, p<0.001). Multivariate analyses revealed that age, LAV and Gal-3 levels were significant independent predictors of PVC positivity (p=0.005, p=0.04, p=0.002, respectively); and Gal-3 was a significant independent predictor of MTWA positivity (p=0.002). Conclusion: Gal-3 was associated with PVC and MTWA positivity, and was a predictor of arrhythmic events in single-vessel STEMI patients with LVEF >35%.

Keywords

• Galectin-3
• Microvolt T-wave Alternans
• Premature Ventricular Complexes
• ST-elevated Myocardial Infarction

Artmış Galektin-3 Düzeyleri, ST Elevasyonlu Miyokart Enfarktüsünü Takiben Gelişen Ventriküler Aritmik Olayları Öngörür

Abstract

Amaç: Sol ventrikül ejeksiyon fraksiyonu (EF) (LVEF) >%35 ve tek damar tıkanıklığı olan ve primer perkütan koroner girişim (pPCI) ile tedavi edilen ST segment elevasyonlu miyokart enfarktüsü (MI) (STEMI) hastalarında, Galektin-3 (Gal-3) düzeyleri ile mikrovolt T dalga alternans (MTWA) ve sık prematüre ventriküler kompleksler (PVC) arasındaki ilişkiyi belirlemeyi amaçladık. Gereç ve Yöntem: Bu kesitsel çalışmaya toplam 81 hasta dahil edildi. Başvuru anında tüm has talardan Gal-3 düzeyleri için kan örnekleri alındı. Hastalar düşük ve yüksek Gal-3 (sırasıyla ≤ ve > 1,93 ng/dL) gruplarına ayrıldı. Düşük Gal-3 ve yüksek Gal-3 grupları hem MTWA hem de PVC pozitifliği açısından karşılaştırılmış ve Gal-3 düzeyleri ile ilişkisi incelenmiştir. Bulgular: Düşük Gal-3 grubu ile karşılaştırıldığında, yüksek Gal-3 hastalarında sol atriyal hacim (LAV) daha yüksekti (55,7±18,0’a karşı 40,6±13,7 mL, p<0,001). Çok değişkenli analizler yaş, LAV ve Gal-3 düzeylerinin PVC pozitifliğinin anlamlı bağımsız prediktörleri olduğunu (sırasıyla p=0,005, p=0,04, p=0,002); ve Gal-3’ün, MTWA pozitifliğinin anlamlı bir bağımsız prediktörü olduğunu gösterdi (p=0,002). Sonuç: Gal-3, PVC ve MTWA pozitifliği ile ilişkiliydi ve LVEF >%35 olan tek damarlı STE-MI hastalarında aritmik olayların bir prediktörü idi.

Keywords

• Galectin-3
• Mikrovolt T Dalgası Değişim Testi
• Ventriküler Erken Atımlar
• ST-yükselmeli Miyokart Enfarktüsü

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