The Association Between Different Revascularization Methods and Left Ventricular Functions and Serum sST2 Levels in Patients with Acute Myocardial Infarction
Abstract
Objectives: We investigated the effects of different revascularization methods on soluble ST2 (sST2) levels and echocardiographic parameters of left
ventricular systole and diastolic in patients admitted with acute myocardial infarction (AMI).
Materials and Methods: A total of 30 patients were included in the study. The study population was divided into two groups. Patients who underwent
primary percutaneous intervention (PCI) or fibrinolytic therapy admitted with AMI were formed the study groups. sST2 and echocardiography
parameters were compared during 3-month follow-up of patients.
Results: There was no difference between sST2 levels in both groups. Left ventricular ejection fraction (LVEF) was higher in the PCI group.
Conclusion: Consequently, the sST2 level did not change in AMI patients regardless of the revascularization method. LVEF was significantly higher
in the PCI group compared to the fibrinolytic group.
Keywords
References
- 1. Thom T, Haase N, Rosamond W, et al. Heart disease and stroke statistics--2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2006;113:e85-151.
- 2. Glasser SP. The time course of left ventricular remodeling after acute myocardial infarction. The American journal of cardiology. 1997;80:506- 507.
- 3. Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation. 1990;81:1161-1172.
- 4. Januzzi JL, Jr. ST2 as a cardiovascular risk biomarker: from the bench to the bedside. Journal of cardiovascular translational research. 2013;6:493-500.
- 5. Ahmad T, Fiuzat M, Felker GM, et al. Novel biomarkers in chronic heart failure. Nature reviews Cardiology. 2012;9:347-359.
- 6. Ibanez B, James S, Agewall S, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). European heart journal. 2018;39:119-177.
- 7. Cantor WJ, Fitchett D, Borgundvaag B, et al. Routine early angioplasty after fibrinolysis for acute myocardial infarction. The New England journal of medicine. 2009;360:2705-2718.
- 8. Di Mario C, Dudek D, Piscione F, et al. Immediate angioplasty versus standard therapy with rescue angioplasty after thrombolysis in the Combined Abciximab REteplase Stent Study in Acute Myocardial Infarction (CARESS-in-AMI): an open, prospective, randomised, multicentre trial. Lancet (London, England). 2008;371:559-568.
- 9. Bohmer E, Hoffmann P, Abdelnoor M, et al. Efficacy and safety of immediate angioplasty versus ischemia-guided management after thrombolysis in acute myocardial infarction in areas with very long transfer distances results of the NORDISTEMI (NORwegian study on DIstrict treatment of STelevation myocardial infarction). J Am Coll of Cardiol. 2010;55:102-110.
- 10. Cheitlin MD, Armstrong WF, Aurigemma GP, et al. ACC/AHA/ASE 2003 Guideline Update for the Clinical Application of Echocardiography: summary article. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASE Committee to Update the 1997 Guidelines for the Clinical Application of Echocardiography). Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. 2003;16:1091-1110.