Repolarization Parameters in Patients with Premature Coronary Artery Disease
Abstract
Objectives: Coronary artery disease (CAD) in young adults is relatively rare. Few data on CAD in young adults are available in the literature. In the current study, repolarization parameters were evaluated in patients with newly diagnosed premature CAD.
Materials and Methods: A total of 200 patients [128 male, 38.0 (29.3-42.0) years] were included and 100 cases with newly diagnosed premature coronary heart disease (aged ≤45 years) formed the study group. Remaining 100 cases were well-matched controls. Repolarization parameters including QTc interval, Tp-e interval and Tp-e∕QTc in leads DII, V2 and V6 were compared between the two groups.
Results: The median QTc interval (430.3 ms vs 405.3 ms, p<0.001) in lead D2, (433.8 ms vs 404.7 ms, p<0.001) in lead V2 and (430.2 ms vs 401.7 ms, p<0.001) in lead V6; the median Tp-e interval (80 ms vs 64 ms, p<0.001) in lead D2, (82 ms vs 74 ms, p<0.001) in lead V2 and (88 ms vs 72 ms, p<0.001) in lead V6; and the median Tp-e/QTc (0.188 vs 0.158, p<0.001) in lead D2, (0.190 vs 0.181, p=0.022) in lead V2 and (0.196 vs 0.183, p<0.001) in lead V6 were significantly higher in patients with premature CAD compared controls, respectively.
Conclusion: In conclusion, premature coronary heart disease may be related to abnormal dispersion of repolarization and subsequent arrhythmic risk.
Keywords
Coronary, Dispersion, Premature, Repolarization
Ethical Statement
Ethics Committee Approval: This study was submitted to and approved by the Ethics Commission of Turkiye Yuksek Ihtisas Training and Research Hospital (Reference number: E.7415).
Informed Consent: This is a retrospective study, so the consent to participate is not applicable.
Peer-review: Externally peer-reviewed.
Authorship Contributions Concept: F.A.E, S.Ç., B.T.T.,
Design: F.A.E, S.Ç., H.K., Ö.Ö.,
F.Ö., S.T., B.T.T, D.A.,
Data Collection or Processing: A.E., S.Ç.,
Analysis or Interpretation: A.E., S.Ç.,
Literature Search: A.E., S.Ç., B.T.T., H.K.,
Writing: A.E., S.Ç.
Conflict of Interest: No conflict of interest was declared by the authors.
Financial Disclosure: The authors declared that this study received no financial support.
References
- 1. Uhl GS, Farrell PW. Myocardial infarction in young adults: risk factors and natural history. Am Heart J. 1983;105:548-553.
- 2. Glover MU, Kuber MT, Warren SE, et al. Myocardial infarction before age 36: risk factor and arteriographic analysis. Am J Cardiol. 1982;49:1600-1603.
- 3. Chouhan L, Hajar HA, Pomposiello JC. Comparison of thrombolytic therapy for acute myocardial infarction in patients aged < 35 and > 55 years. Am J Cardiol. 1993;71:157-159.
- 4. Egred M, Viswanathan G, Davis GK. Myocardial infarction in young adults. Postgrad Med J. 2005;81:741-745.
- 5. van Loon JE, de Maat MP, Deckers JW, et al. Prognostic markers in young patients with premature coronary heart disease. Atherosclerosis. 2012;224:213-217.
- 6. Konishi H, Miyauchi K, Kasai T, et al. Long-term prognosis and clinical characteristics of young adults (
- 7. Genest JJ, McNamara JR, Salem DN, et al. Prevalence of risk factors in men with premature coronary artery disease. Am J Cardiol. 1991;67:1185-1189.
- 8. Christus T, Shukkur AM, Rashdan I, et al. Coronary Artery Disease in Patients Aged 35 or less - A Different Beast? Heart Views. 2011;12:7-11. PubMed PMID: 21731802.
- 9. Akosah KO, Schaper A, Cogbill C, et al. Preventing myocardial infarction in the young adult in the first place: how do the National Cholesterol Education Panel III guidelines perform? J Am Coll Cardiol. 2003;41:1475- 1479.
- 10. Doughty M, Mehta R, Bruckman D, et al. Acute myocardial infarction in the young--The University of Michigan experience. Am Heart J. 2002;143:56-62.