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Assessment of Effectiveness and Safety of Upper Gastrointestinal System Endoscopy in Geriatric Patients

Year 2018, Volume: 71 Issue: 3, 228 - 233, 31.12.2018

Abstract

Objectives: Upper gastrointestinal system (GIS) endoscopy is an important diagnostic and therapeutic tool in geriatric patients, similarly to other
age groups. Here we aimed to present the indications, endoscopic and pathologic findings and also endoscopy related complications of upper
endoscopic procedures in our geriatric population.

Materials and Methods: This study was designed as a retrospective study. Patients over 65 years old who had either diagnostic and/or therapeutic
upper gastrointestinal system endoscopy between 1 January 2017-1 January 2018 in Keçiören Training and Research Hospital were enrolled into the
study. Based on their age, patients were divided into two subgroups: group 1: patients aged between 65-80 years old and group 2: patients aged
over 80 years old.

Results: Overall 1154 patients (median age 74.2±6.38, male/female: 44.7/55.3) were enrolled into the study. Tissue biopsy was performed in 1018
patients. The most frequent upper GIS endoscopy indication was dyspepsia (86.3%). Gastritis (81.5%) and lower esophageal sphincter (LES) relaxation
(34%) were the most frequent endoscopic findings. Nevertheless the frequency of gastric cancer and peptic ulcer were 1.4% and 1.1%, respectively.
The frequency of H. pylori in our patients was 41.7%. Between two groups, endoscopy indications, endoscopic findings and frequency of H. pylori
were not significantly different. We did not observe any complication and upper GIS endoscopy associated mortality in our patientsConclusion: Upper GIS endoscopy can be perform in terms of diagnostic or therapeutic with safely in geriatric patients even if patient is extremely
elder. Age, alone must not a router to decide upper GIS endoscopy in geriatric patient.

Project Number

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References

  • 1. Franceschi M, Di Mario F, Leandro G, et al. Acid-related disorders in the elderly. Best Pract Res Clin Gastroenterol. 2009;23:839-848.
  • 2. Jim MA, Pinheiro PS, Carreira H, et al. Stomach cancer survival in the United States by race and stage (2001-2009): Findings from the CONCORD-2 study. Cancer. 2017;24:4994-5013.
  • 3. Wongrakpanich S, Wongrakpanich A, Melhado K, et al. A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug Use in The Elderly. Aging Dis. 2018;9:143-150.
  • 4. Kandemir A, Arabul M, Çelik M, ve ark. Yaşlı Hastalarda Gastrointestinal Endoskopik İncelemerin Değerlendirilmesi. Turkish Journal of Geriatrics 2013;16:43-47.
  • 5. Durazzo M, Campion D, Fagoonee S, Pellicano R. Gastrointestinal tract disorders in the elderly. Minerva Med. 2017;108:575-591.
  • 6. Clarke GA, Jacobson BC, Hammett RJ, et al. The indications, utilization and safety of gastrointestinal endoscopy in an extremely elderly patients cohort. Endoscopy. 2001;33:580-584
  • 7. Seinelä L, Ahvenainen J, Rönneikkö J, et al. Reasons for and outcome of upper gastrointestinal endoscopy in patients aged 85 years or more: retrospective study. BMJ. 1998;317:575-580.
  • 8. Lee TC, Huang SP, Yang JY, et al. Age is not a discriminating factor for outcomes of therapeutic upper gastrointestinal endoscopy. Hepatogastroenterology. 2007;54:1319-1322.
  • 9. Kawaguchi K, Kurumi H, Takeda Y, et al. Management for non-variceal bleeding in elderly patients: the gastrointestinal bleeding in elderly patients: the experience of a tertiary university hospital. Ann Transl Med. 2017;5:181.
  • 10. Van Kouwen MC, Drenth JP, Verhoeven HM, et al. Upper gastrointestinal endoscopy in patients aged 85 years or more. Results of a feasibility study in a district general hospitalArch Gerontol Geriatr. 2003;37:45-50.
  • 11. Archimandritis A, Spiliadis C, Tzivras M, et al. Gastric epithelial polyps: a retrospective endoscopic study of 12974 symptomatic patients. Ital J Gastroenterol. 1996;28:387-390
  • 12. Jalving M, Koornstra JJ, Wesseling J, et al. Increased risk of fundic gland polyps during long-term proton pump inhibitor therapy. Aliment Pharmacol Ther. Aliment Pharmacol Ther. 2006;24:1341-1348.
  • 13. Pilotto A. Aging and the gastrointestinal tract. Ital J Gastroenterol Hepatol 1999;31:137-153.
  • 14. Pilotto A, Franceschi M, Valerio G, et al. Helicobacter pylori infection in elderly patients with peptic ulcer. Age Ageing. 1999;28:412-414.
  • 15. Nagini S. Carcinoma of the stomach: A review of epidemiology, pathogenesis, molecular genetics and chemoprevention. World J Gastrointest Oncol 2012;4:156-169.
  • 16. Daniel VT, Wiseman JT, Flahive J,et al. Predictors of mortality in the elderly after open repair for perforated peptic ulcer disease J Surg Res. 2017l;215:108-113.

Geriatrik Hastalarda Üst Gastrointestinal Sistem Endoskopisinin Etkinlik ve Güvenilirliğinin Değerlendirilmesi

Year 2018, Volume: 71 Issue: 3, 228 - 233, 31.12.2018

Abstract

Amaç: Üst gastrointestinal sistem (GİS) endoskopisi diğer hastalarda olduğu gibi geriatrik hastalarda da önemli bir tanısal ve terapötik araçtır. Biz
bu çalışmada geriatrik hastalarımızda yapılan üst GİS endoskopi işlemlerinin endikasyonlarını, endoskopide tanı alan lezyonların sıklığını ve bu yaş
grubunun mide patolojilerinin değerlendirilmesini amaçladık.

Gereç ve Yöntem: Bu çalışmaya Sağlık Bilimleri Üniversitesi, Keçiören Eğitim ve Araştırma Hastanesi, Gastroenteroloj Bilim Dalı Endoskopi Ünitesi’nde
1 Ocak 2017-1 Ocak 2018 tarihleri arasında üst gastrointestinal sistem endoskopisi yapılan 65 yaş ve üzeri hastalar retrospektif olarak dahil edildi.
Çalışmaya alınan hastalar yaşlarına göre iki gruba ayrıldı: 65-80 yaş arası grup 1 ve 80 yaş üzeri grup 2.

Bulgular: Çalışmaya toplam 1154 hasta (yaş ortalaması: 74,2±6,38, erkek/kadın: 44,7/55,3) alındı. Bu hastaların 1018 tanesinden endoskopi
esnasında biyopsi ve/veya doku örneklemesi yapıldı. En sık endoskopi endikasyonu dispepsi (%86,3) idi. Gastrit (%81,5) ve alt özofagus sfinkter
(AÖS) gevşekliği (%34) en sık izlenen endoskopik bulgularken mide kanseri %1,4, peptik ülser %1,1 sıklıkta izlendi. Hastalarımızda H. pylori sıklığı
%41,7’ydi. Endoskopi endikasyonları, endoskopik bulgular ve H. pylori varlığı gruplar arasında anlamlı farklılık göstermedi. Hastalarımızın hiçbirinde
tanısal ve terapötik üst GİS endoskopisine bağlı olarak komplikasyon ve mortalite izlenmedi.

Sonuç: Geriatrik hastalarda üst GİS endoskopisi, hastalar çok ileri yaş olsalar dahi tanısal ve terapötik amaçla güvenli bir şekilde kullanılabilir. Yaş
tek başına endoskopi işlemine karar vermede yönlendirici olmamalıdır

Ethical Statement

Etik Kurul Onayı: Çalışma retrospektif olduğu için etik kurul onayı alınmamıştır. Hasta Onayı: Çalışma retrospektif olduğu için hasta onayı alınmamıştır. Hakem Değerlendirmesi: Editörler kurulu tarafından değerlendirilmiştir. Yazarlık Katkıları Cerrahi ve Medikal Uygulama: M.Y.A., E.K.A., F.P.S., M.U., Y.N., Konsept: M.Y.A., E.K.A., Dizayn: E.K.A., M.Y.A., Veri Toplama veya İşleme: M.U., Y.N., F.P.S., Analiz veya Yorumlama: Z.G. Literatür Arama: M.Y.A., F.P.S., Yazan: M.Y.A., Çıkar Çatışması: Yazarlar tarafından çıkar çatışması bildirilmemiştir. Finansal Destek: Yazarlar tarafından finansal destek almadıkları bildirilmiştir.

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Project Number

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Thanks

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References

  • 1. Franceschi M, Di Mario F, Leandro G, et al. Acid-related disorders in the elderly. Best Pract Res Clin Gastroenterol. 2009;23:839-848.
  • 2. Jim MA, Pinheiro PS, Carreira H, et al. Stomach cancer survival in the United States by race and stage (2001-2009): Findings from the CONCORD-2 study. Cancer. 2017;24:4994-5013.
  • 3. Wongrakpanich S, Wongrakpanich A, Melhado K, et al. A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug Use in The Elderly. Aging Dis. 2018;9:143-150.
  • 4. Kandemir A, Arabul M, Çelik M, ve ark. Yaşlı Hastalarda Gastrointestinal Endoskopik İncelemerin Değerlendirilmesi. Turkish Journal of Geriatrics 2013;16:43-47.
  • 5. Durazzo M, Campion D, Fagoonee S, Pellicano R. Gastrointestinal tract disorders in the elderly. Minerva Med. 2017;108:575-591.
  • 6. Clarke GA, Jacobson BC, Hammett RJ, et al. The indications, utilization and safety of gastrointestinal endoscopy in an extremely elderly patients cohort. Endoscopy. 2001;33:580-584
  • 7. Seinelä L, Ahvenainen J, Rönneikkö J, et al. Reasons for and outcome of upper gastrointestinal endoscopy in patients aged 85 years or more: retrospective study. BMJ. 1998;317:575-580.
  • 8. Lee TC, Huang SP, Yang JY, et al. Age is not a discriminating factor for outcomes of therapeutic upper gastrointestinal endoscopy. Hepatogastroenterology. 2007;54:1319-1322.
  • 9. Kawaguchi K, Kurumi H, Takeda Y, et al. Management for non-variceal bleeding in elderly patients: the gastrointestinal bleeding in elderly patients: the experience of a tertiary university hospital. Ann Transl Med. 2017;5:181.
  • 10. Van Kouwen MC, Drenth JP, Verhoeven HM, et al. Upper gastrointestinal endoscopy in patients aged 85 years or more. Results of a feasibility study in a district general hospitalArch Gerontol Geriatr. 2003;37:45-50.
  • 11. Archimandritis A, Spiliadis C, Tzivras M, et al. Gastric epithelial polyps: a retrospective endoscopic study of 12974 symptomatic patients. Ital J Gastroenterol. 1996;28:387-390
  • 12. Jalving M, Koornstra JJ, Wesseling J, et al. Increased risk of fundic gland polyps during long-term proton pump inhibitor therapy. Aliment Pharmacol Ther. Aliment Pharmacol Ther. 2006;24:1341-1348.
  • 13. Pilotto A. Aging and the gastrointestinal tract. Ital J Gastroenterol Hepatol 1999;31:137-153.
  • 14. Pilotto A, Franceschi M, Valerio G, et al. Helicobacter pylori infection in elderly patients with peptic ulcer. Age Ageing. 1999;28:412-414.
  • 15. Nagini S. Carcinoma of the stomach: A review of epidemiology, pathogenesis, molecular genetics and chemoprevention. World J Gastrointest Oncol 2012;4:156-169.
  • 16. Daniel VT, Wiseman JT, Flahive J,et al. Predictors of mortality in the elderly after open repair for perforated peptic ulcer disease J Surg Res. 2017l;215:108-113.
There are 16 citations in total.

Details

Primary Language English
Subjects Gastroenterology Surgery
Journal Section Research Article
Authors

Evrim Kahramanoğlu Aksoy 0000-0001-8887-3428

Muhammet Yener Akpınar 0000-0003-0903-4664

Ferdane Pirinççi Sapmaz This is me 0000-0003-1278-110X

Zeynep Göktaş 0009-0009-2629-4362

Metin Uzman 0000-0001-5504-0470

Yaşar Nazlıgül This is me 0000-0003-1926-4594

Project Number -
Publication Date December 31, 2018
Published in Issue Year 2018 Volume: 71 Issue: 3

Cite

APA Kahramanoğlu Aksoy, E., Akpınar, M. Y., Pirinççi Sapmaz, F., … Göktaş, Z. (2018). Assessment of Effectiveness and Safety of Upper Gastrointestinal System Endoscopy in Geriatric Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 71(3), 228-233. https://doi.org/10.4274/atfm.20982
AMA Kahramanoğlu Aksoy E, Akpınar MY, Pirinççi Sapmaz F, Göktaş Z, Uzman M, Nazlıgül Y. Assessment of Effectiveness and Safety of Upper Gastrointestinal System Endoscopy in Geriatric Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası. December 2018;71(3):228-233. doi:10.4274/atfm.20982
Chicago Kahramanoğlu Aksoy, Evrim, Muhammet Yener Akpınar, Ferdane Pirinççi Sapmaz, Zeynep Göktaş, Metin Uzman, and Yaşar Nazlıgül. “Assessment of Effectiveness and Safety of Upper Gastrointestinal System Endoscopy in Geriatric Patients”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 71, no. 3 (December 2018): 228-33. https://doi.org/10.4274/atfm.20982.
EndNote Kahramanoğlu Aksoy E, Akpınar MY, Pirinççi Sapmaz F, Göktaş Z, Uzman M, Nazlıgül Y (December 1, 2018) Assessment of Effectiveness and Safety of Upper Gastrointestinal System Endoscopy in Geriatric Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası 71 3 228–233.
IEEE E. Kahramanoğlu Aksoy, M. Y. Akpınar, F. Pirinççi Sapmaz, Z. Göktaş, M. Uzman, and Y. Nazlıgül, “Assessment of Effectiveness and Safety of Upper Gastrointestinal System Endoscopy in Geriatric Patients”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 71, no. 3, pp. 228–233, 2018, doi: 10.4274/atfm.20982.
ISNAD Kahramanoğlu Aksoy, Evrim et al. “Assessment of Effectiveness and Safety of Upper Gastrointestinal System Endoscopy in Geriatric Patients”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 71/3 (December2018), 228-233. https://doi.org/10.4274/atfm.20982.
JAMA Kahramanoğlu Aksoy E, Akpınar MY, Pirinççi Sapmaz F, Göktaş Z, Uzman M, Nazlıgül Y. Assessment of Effectiveness and Safety of Upper Gastrointestinal System Endoscopy in Geriatric Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2018;71:228–233.
MLA Kahramanoğlu Aksoy, Evrim et al. “Assessment of Effectiveness and Safety of Upper Gastrointestinal System Endoscopy in Geriatric Patients”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 71, no. 3, 2018, pp. 228-33, doi:10.4274/atfm.20982.
Vancouver Kahramanoğlu Aksoy E, Akpınar MY, Pirinççi Sapmaz F, Göktaş Z, Uzman M, Nazlıgül Y. Assessment of Effectiveness and Safety of Upper Gastrointestinal System Endoscopy in Geriatric Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2018;71(3):228-33.