Stent Restenozunu Öngörmede Potansiyel Bir Belirteç: Platelet Dağılım Aralığı/Platelet Oranı

Firdevs Ayşenur Ekizler; Serkan Çay

doi:10.4274/atfm.76476

EN TR

Stent Restenozunu Öngörmede Potansiyel Bir Belirteç: Platelet Dağılım Aralığı/Platelet Oranı

Abstract

Objectives: Platelets play significant role in the pathogenesis of in-stent restenosis (ISR). Platelet distribution width to platelet count ratio (PDW/platelet) is a new marker. There are no data available regarding the predictive role of PDW/platelet ratio for ISR in patients with coronary artery disease. The present study aimed to search the predictive value of preprocedural PDW/platelet ratio on in-stent restenosis in patients with stable or unstable angina pectoris undergoing coronary bare-metal stent implantation. Materials and Methods: We retrospectively analyzed clinical, biochemical, and angiographic data from 763 consecutive patients [mean age 60.3±10.2 years, 546 (71%) male]; all patients had undergone elective bare-metal stent implantation and further control coronary angiography owing to angina pectoris or ischemia. Results: The mean period between stent implantation and control coronary angiography procedures was 15.3±8.7 months. The preprocedural PDW/platelet ratios were significantly higher in patients that had ISR (odds ratio, 3.43; 95% confidence interval, 2.02-5.83; p<0.001). Smoking, uric acid, C-reactive protein levels and PDW/platelet levels identified as independent predictors of ISR. Conclusion: Our results demonstrate that higher PDW/platelet ratio is an independent and powerful predictor of ISR in patients with stable or unstable angina pectoris who underwent successful bare-metal stent implantation

Keywords

Marker, In-stent Restenosis, Platelet Distribution Width to Platelet Count Ratio

A Potantiel Marker of in-Stent Restenosis: Platelet Distribution Width/Platelet Ratio

Abstract

Amaç: Plateletlerin in-stent restenoz (İSR) patogenezinde önemli rolleri vardır. Platelet dağılım aralığının platelet sayısına oranı (PDW/platelet) yakın zaman önce ortaya çıkan bir belirteçtir. Bu oranın koroner arter hastalığında stent restenozunu öngörmedeki prediktif değeriyle ilgili veri yoktur. Çalışmamızda bu nedenle kararlı veya kararsız anjina nedeniyle çıplak metal stent takılan hastalarda prosedür öncesi bakılan PDW/platelet oranının İSR’nin öngörmedeki rolünü araştırmayı amaçladık. Gereç ve Yöntem: Çalışmamızda elektif çıplak metal stent takılan ve anjina ya da iskemi nedeniyle nedeniyle kontrol anjiyografileri yapılan toplam 763 ardışık hastanın [ortalama yaş 60,3±10,2 yıl, 546 (%71) erkek]; klinik, biyokimyasal ve anjiyografik verilerini retrospektif olarak inceledik. Bulgular: Stent implantasyonu ve kontrol koroner anjiyografi arasındaki zaman periyodu ortalama 15,3±8,7 aydı. Prosedür öncesi bakılan PDW/platelet oranı İSR olan hastalarda anlamlı olarak daha yüksekti (odds ratio, 3,43; %95 güven aralığı, 2,02-5,83; p<0,001). Sigara içme, ürik asit düzeyi, C-reaktif protein seviyeleri ve PDW/platelet oranları İSR’nin bağımsız öngördürücüleri olarak saptandı. Sonuç: Kararlı ve kararsız anjinası olup çıplak metal stent takılan hastalarda PDW/platelet oranı İSR’nin bağımsız ve güçlü bir prediktörüdür.

Keywords

Belirteç, İn-stent Restenoz, Platelet Dağılım Aralığının Platelet Sayısına Oranı

Ethical Statement

Etik Kurul Onayı: Çalışma için Sağlık Bilimleri Üniversitesi, Ankara Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi Etik Kurulu’ndan onay alınmıştır (tarih: 09.07.2018, no: 7806).

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Details

Primary Language

English

Subjects

Cardiology

Journal Section

Research Article

Authors

Firdevs Ayşenur Ekizler ^*
0000-0002-3988-6828
Türkiye

Serkan Çay
0000-0002-5476-1214
Türkiye

Publication Date

October 10, 2018

Submission Date

July 18, 2018

Acceptance Date

August 17, 2018

Published in Issue

Year 2018 Volume: 71 Number: 2

DOI

https://doi.org/10.4274/atfm.76476

IZ

https://izlik.org/JA39NY27NW

APA

Ekizler, F. A., & Çay, S. (2018). Stent Restenozunu Öngörmede Potansiyel Bir Belirteç: Platelet Dağılım Aralığı/Platelet Oranı. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 71(2), 123-129. https://doi.org/10.4274/atfm.76476

AMA

1.Ekizler FA, Çay S. Stent Restenozunu Öngörmede Potansiyel Bir Belirteç: Platelet Dağılım Aralığı/Platelet Oranı. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2018;71(2):123-129. doi:10.4274/atfm.76476

Chicago

Ekizler, Firdevs Ayşenur, and Serkan Çay. 2018. “Stent Restenozunu Öngörmede Potansiyel Bir Belirteç: Platelet Dağılım Aralığı Platelet Oranı”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 71 (2): 123-29. https://doi.org/10.4274/atfm.76476.

EndNote

Ekizler FA, Çay S (October 1, 2018) Stent Restenozunu Öngörmede Potansiyel Bir Belirteç: Platelet Dağılım Aralığı/Platelet Oranı. Ankara Üniversitesi Tıp Fakültesi Mecmuası 71 2 123–129.

IEEE

[1]F. A. Ekizler and S. Çay, “Stent Restenozunu Öngörmede Potansiyel Bir Belirteç: Platelet Dağılım Aralığı/Platelet Oranı”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 71, no. 2, pp. 123–129, Oct. 2018, doi: 10.4274/atfm.76476.

ISNAD

Ekizler, Firdevs Ayşenur - Çay, Serkan. “Stent Restenozunu Öngörmede Potansiyel Bir Belirteç: Platelet Dağılım Aralığı Platelet Oranı”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 71/2 (October 1, 2018): 123-129. https://doi.org/10.4274/atfm.76476.

JAMA

1.Ekizler FA, Çay S. Stent Restenozunu Öngörmede Potansiyel Bir Belirteç: Platelet Dağılım Aralığı/Platelet Oranı. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2018;71:123–129.

MLA

Ekizler, Firdevs Ayşenur, and Serkan Çay. “Stent Restenozunu Öngörmede Potansiyel Bir Belirteç: Platelet Dağılım Aralığı Platelet Oranı”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 71, no. 2, Oct. 2018, pp. 123-9, doi:10.4274/atfm.76476.

Vancouver

1.Firdevs Ayşenur Ekizler, Serkan Çay. Stent Restenozunu Öngörmede Potansiyel Bir Belirteç: Platelet Dağılım Aralığı/Platelet Oranı. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2018 Oct. 1;71(2):123-9. doi:10.4274/atfm.76476

Stent Restenozunu Öngörmede Potansiyel Bir Belirteç: Platelet Dağılım Aralığı/Platelet Oranı

Abstract

Keywords

A Potantiel Marker of in-Stent Restenosis: Platelet Distribution Width/Platelet Ratio

Abstract

Keywords

Ethical Statement

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

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