Research Article

An Analysis of Xanthogranulomatous Cholecystitis Cases

Volume: 71 Number: 1 October 16, 2018
Serhat Tokgöz , Muzaffer Akkoca , Demet Yılmazer , Şener Balas , Cem Azılı , Kerim Bora Yılmaz , Ahmet Oğuz Hasdemir
EN TR

An Analysis of Xanthogranulomatous Cholecystitis Cases

Abstract

Aim: Xanthogranulomatous cholecystitis (XGC) is usually an inflammatory condition due to gallstones and bile stasis. Pathological, radiological and clinical features are similar to gallbladder cancer, leading to erroneous treatments such as excessive or inadequate surgery. The aim of this study was to identify the clinical and surgical characteristics of XGC cases. Materials and Methods: The medical records were reviewed of 55 patients diagnosed as XGC from 4818 patients who underwent cholecystectomy between 2008 and 2015. Results: The most common clinical finding (90%) was right upper quadrant pain, followed by acute cholecystitis (30%). Biliary wall thickening was found in 64% of patients. Conversion to open cholecystectomy rate was 39%, which was significantly higher than that of all cholecystectomies conversion rates 3.4%. Postoperative biliary fistula was determined at 9% and total morbidity at 23%. Conclusion: XGC is a rare form of cholecystitis. Although it is histologically benign, preoperative and intraoperative diagnosis is difficult and complicated due to its aggressive course. Although carcinoma may be suspected during surgery in XGC, the association is not very high. It is quite useful to study frozen samples to avoid extensive surgery. The definitive treatment is surgery, but it should not be forgotten that there are high morbidity rates during and after the operation

Keywords

xanthogranulomatosis, cholecystitis, conversion cholecystectomy

References

  1. 1) Dixit VK, Parakash A, Gupta A, Pandey M, Gautam A, Kumar M, Shukla VK. Xanthogranulomatous cholecystitis. Dig Dis Sci. 1998 May;43(5):940–942.
  2. 2) Gilberto Guzman-Valdivia. Xanthogranulomatous Cholecystitis: 15 years Experience. World J Surg. 2004;28: 254–257.
  3. 3) Mori M, Watanabe M, Sakuma M, Tsutsumi Y. Infectious etiology of xanthogranulomatous cholecystitis: Immunohistochemical identification of bacterial antigens in the xanthogranulomatous lesions. Pathol Int. 1999;49:849–852
  4. 4) Seiko Sawada, Kenichi Harada, Kumiko Isse, Yasunori Sato, Motoko sasaki, Yasuharu Kaizaki, Yasi Nakanuma. Involvement of Escherichia coli in pathogenesis of xanthogranulomatous cholecystitis with scavenger receptor class A and CXCL16-CXCR6 interaction. Pathol Int. 2007;57:652–663.
  5. 5) Goodman Z, Ishak K. (1981) Xanthogranulomatous cholecystitis. Am J Surg Pathol 5:653–659.
  6. 6) Roberts K, Parsons M. (1987) Xanthogranulomatous cholecystitis:clinico-pathological study of 13 cases. J Clin Pathol 40:412–417
  7. 7) Yoshida J, Chijiiwa K, Shimura H, et al. Xanthogranulomatous cholecystitis versus gallbladder cancer: Clinical differentiating factors. Am Surg. 1997;63(4):367–371.
  8. 8) Adachi Y, Iso Y, Moriyama M, et al. Increased serum CA 19-9 in patients with xanthogranulomatous cholecystitis. Hepatogastroenterology. 1998;45(19):77–80.
  9. 9) L.-F.Zhang,C.-S.Hou, J.-Y.Liuet al., “Strategies for diagnosisof xanthogranulomatous cholecystitis masquerading as gallbladder cancer,” ChineseMedical Journal, vol. 125, no. 1, pp. 109–113, 2012.
  10. 10) Krishnani N, Dhingra S, Kapoor S, Pandey R. (2007) Cytopathologic diagnosis of xanthogranulomatous cholecystitis and coexistent lesions. A prospective study of 31 cases. Acta Cytol 51:37–41.
APA
Tokgöz, S., Akkoca, M., Yılmazer, D., Balas, Ş., Azılı, C., Yılmaz, K. B., & Hasdemir, A. O. (2018). An Analysis of Xanthogranulomatous Cholecystitis Cases. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 71(1), 81-86. https://izlik.org/JA78AF84FB
AMA
1.Tokgöz S, Akkoca M, Yılmazer D, et al. An Analysis of Xanthogranulomatous Cholecystitis Cases. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2018;71(1):81-86. https://izlik.org/JA78AF84FB
Chicago
Tokgöz, Serhat, Muzaffer Akkoca, Demet Yılmazer, et al. 2018. “An Analysis of Xanthogranulomatous Cholecystitis Cases”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 71 (1): 81-86. https://izlik.org/JA78AF84FB.
EndNote
Tokgöz S, Akkoca M, Yılmazer D, Balas Ş, Azılı C, Yılmaz KB, Hasdemir AO (October 1, 2018) An Analysis of Xanthogranulomatous Cholecystitis Cases. Ankara Üniversitesi Tıp Fakültesi Mecmuası 71 1 81–86.
IEEE
[1]S. Tokgöz et al., “An Analysis of Xanthogranulomatous Cholecystitis Cases”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 71, no. 1, pp. 81–86, Oct. 2018, [Online]. Available: https://izlik.org/JA78AF84FB
ISNAD
Tokgöz, Serhat - Akkoca, Muzaffer - Yılmazer, Demet - Balas, Şener - Azılı, Cem - Yılmaz, Kerim Bora - Hasdemir, Ahmet Oğuz. “An Analysis of Xanthogranulomatous Cholecystitis Cases”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 71/1 (October 1, 2018): 81-86. https://izlik.org/JA78AF84FB.
JAMA
1.Tokgöz S, Akkoca M, Yılmazer D, Balas Ş, Azılı C, Yılmaz KB, Hasdemir AO. An Analysis of Xanthogranulomatous Cholecystitis Cases. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2018;71:81–86.
MLA
Tokgöz, Serhat, et al. “An Analysis of Xanthogranulomatous Cholecystitis Cases”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 71, no. 1, Oct. 2018, pp. 81-86, https://izlik.org/JA78AF84FB.
Vancouver
1.Serhat Tokgöz, Muzaffer Akkoca, Demet Yılmazer, Şener Balas, Cem Azılı, Kerim Bora Yılmaz, Ahmet Oğuz Hasdemir. An Analysis of Xanthogranulomatous Cholecystitis Cases. Ankara Üniversitesi Tıp Fakültesi Mecmuası [Internet]. 2018 Oct. 1;71(1):81-6. Available from: https://izlik.org/JA78AF84FB