Gestational Trophoblastic Disease with Pulmonary and Cerebral Metastasis: Can Fluorodeoxyglucose Positron Emission Tomography Really Detect Cranial Metastatic Disease ?

Ulaş Kumbasar; Serkan Uysal; Tuba Şahinoğlu; Sevgen Önder; Metin Demircin

Case Report

Gestational Trophoblastic Disease with Pulmonary and Cerebral Metastasis: Can Fluorodeoxyglucose Positron Emission Tomography Really Detect Cranial Metastatic Disease ?

Year 2016, Volume: 69 Issue: 3, 257 - 260, 31.12.2016

Ulaş Kumbasar , Serkan Uysal , Tuba Şahinoğlu , Sevgen Önder , Metin Demircin

Abstract

Gestational trophoblastic neoplasms (GTN) originate from placental tissue and usually metastasizes because
of its propensity for early vascular invasion. Intracranial metastases are relatively uncommon. There are
limited data on the efficacy of 18-fluorodeoxyglucose positron emission tomography (FDG-PET) in the evaluation of metastatic GTN. We present a case of GTN with simultaneous pulmonary and cranial metastases in
which the cranial metasteses were undetectable with positron emission tomography (PET) scan.

Keywords

Gestational Trophoblastic Neoplasms , Cranial Metastasis , Positron Emission Tomography

References

1. Szulman AE. Trophoblastic disease: clinical pathology of hydatidiform moles. Obstet Gynecol Clin North Am 1988;15: 443–456.
2. Bagshawe KD. Risks and prognostic factors in trophoblastic neoplasia. Cancer 1976;38:1373–1385.
3. Berkowitz RS, Goldstein DP. Pathogenesis of gestational trophoblastic neoplasms. Pathobiol Ann 1981;11:391–411.
4. Berkowitz RS, Goldstein DP. Current management of gestational trophoblastic diseases. Gynecologic Oncology; 2003;112: 654-662.
5. Lathrop JC, Lauchlan S, Nayak R. Clinical characteristics of placental site trophoblastic tumor. Gynecol Oncol 1988;31:32-42.
6. Bagshawe KD, Noble MIM. Cardiorespiratory aspects of trophoblastic tumors. Q J Med 1966;137:39–54.
7. Suresh TN, Santosh V, Shastry Kolluri VR. Intracranial haemorrhage resulting from unsuspected choriocarcinoma metastasis. Neurol India 2001;49:231–236.
8. Hammond CB, Weed JC, Currie JL. The role of operation in the current therapy of gestational trophoblastic disease. Amer J Obstet Gynecol 1980;136:844–856.
9. Watanabe AS, Smoker WR. Computed tomography and angiographic findings in metastatic choriocarcinoma. J Comput Assist Tomogr 1989;13:319–322.
10. Dhillon T, Palmieri C, Sebire NJ, et al. Value of whole body 18 FDG-PET to identify the active site of gestational trophoblastic neoplasia. J Reprod Med 2006;51:879–887.
11. Allen SD, Lim AK, Seckl MJ, Blunt DM, Mitchell AW. Radiology of gestational trophoblastic neoplasia. Clinical radiology 2006; 61:301-313.
12. Dose J, Bohuslavizki K, Huneke B, et al. Detection of intramural choriocarcinoma of the uterus with FDG-PET: a case report. Clin Positron Imaging 2000;3:37-40.
13. Hebart H, Erley C, Kaskas B, et al. Positron emission tomography helps to diagnose tumor emboli and residual disease in choriocarcinoma. Ann Oncol 1996;7:416– 418.
14. Zhuang H, Yamamoto AJ, Ghesani N, Alavi A. Detection of choriocarcinoma in the lung by FDG positron emission tomography. Clin Nucl Med 2001;26:723.
15. Sironi S, Pichio M, Mangili G, et al. Fluorodeoxyglucose positron emission tomography as a useful indicator of metastatic gestational trophoblastic tumor: preliminary results in three patients. Gynecologic oncology 2003;91:226-230.
16. Coleman RE. PET in lung cancer staging. Q J Nucl Med. 2001;45:231-234.

Akciğer ve Beyin Metastazlı Gestasyonel Trofoblastik Hastalık: Pozitron Emisyon Tomografisi Kranial Metastatik Hastalığı Saptayabiliyor mu?

Year 2016, Volume: 69 Issue: 3, 257 - 260, 31.12.2016

Ulaş Kumbasar , Serkan Uysal , Tuba Şahinoğlu , Sevgen Önder , Metin Demircin

Abstract

Gestasyonel Trofoblastik Neoplaziler (GTN) plasenta dokusundan köken alırlar ve erken vasküler invazyon
yaptıklarından sıklıkla metastaz yaparlar. Beyin metastazı nadir görülür. Metastatik GTN’nin taranmasında
18-florodeoksiglukoz pozitron emisyon tomografisinin (FDG-PET) etkinliği konusunda veriler yetersizdir. Bu
olgu sunumunda, eş zamanlı akciğer ve beyin metastazı olan ve beyin metastazının FDG-PET ile saptanamadığı bir GTN olgusunu sunuyoruz.

Keywords

Gestasyonel Trofoblastik Neoplazi , Beyin Metastazı , Pozitron Emisyon Tomografisi

References

1. Szulman AE. Trophoblastic disease: clinical pathology of hydatidiform moles. Obstet Gynecol Clin North Am 1988;15: 443–456.
2. Bagshawe KD. Risks and prognostic factors in trophoblastic neoplasia. Cancer 1976;38:1373–1385.
3. Berkowitz RS, Goldstein DP. Pathogenesis of gestational trophoblastic neoplasms. Pathobiol Ann 1981;11:391–411.
4. Berkowitz RS, Goldstein DP. Current management of gestational trophoblastic diseases. Gynecologic Oncology; 2003;112: 654-662.
5. Lathrop JC, Lauchlan S, Nayak R. Clinical characteristics of placental site trophoblastic tumor. Gynecol Oncol 1988;31:32-42.
6. Bagshawe KD, Noble MIM. Cardiorespiratory aspects of trophoblastic tumors. Q J Med 1966;137:39–54.
7. Suresh TN, Santosh V, Shastry Kolluri VR. Intracranial haemorrhage resulting from unsuspected choriocarcinoma metastasis. Neurol India 2001;49:231–236.
8. Hammond CB, Weed JC, Currie JL. The role of operation in the current therapy of gestational trophoblastic disease. Amer J Obstet Gynecol 1980;136:844–856.
9. Watanabe AS, Smoker WR. Computed tomography and angiographic findings in metastatic choriocarcinoma. J Comput Assist Tomogr 1989;13:319–322.
10. Dhillon T, Palmieri C, Sebire NJ, et al. Value of whole body 18 FDG-PET to identify the active site of gestational trophoblastic neoplasia. J Reprod Med 2006;51:879–887.
11. Allen SD, Lim AK, Seckl MJ, Blunt DM, Mitchell AW. Radiology of gestational trophoblastic neoplasia. Clinical radiology 2006; 61:301-313.
12. Dose J, Bohuslavizki K, Huneke B, et al. Detection of intramural choriocarcinoma of the uterus with FDG-PET: a case report. Clin Positron Imaging 2000;3:37-40.
13. Hebart H, Erley C, Kaskas B, et al. Positron emission tomography helps to diagnose tumor emboli and residual disease in choriocarcinoma. Ann Oncol 1996;7:416– 418.
14. Zhuang H, Yamamoto AJ, Ghesani N, Alavi A. Detection of choriocarcinoma in the lung by FDG positron emission tomography. Clin Nucl Med 2001;26:723.
15. Sironi S, Pichio M, Mangili G, et al. Fluorodeoxyglucose positron emission tomography as a useful indicator of metastatic gestational trophoblastic tumor: preliminary results in three patients. Gynecologic oncology 2003;91:226-230.
16. Coleman RE. PET in lung cancer staging. Q J Nucl Med. 2001;45:231-234.

There are 16 citations in total.

Details

Primary Language	English
Subjects	Surgical Diseases Nursing
Journal Section	Case Report
Authors	Ulaş Kumbasar 0000-0003-0616-1326 Serkan Uysal 0009-0000-2466-4993 Tuba Şahinoğlu 0000-0002-1085-4865 Sevgen Önder 0000-0002-5523-0669 Metin Demircin 0000-0002-4756-3869
Publication Date	December 31, 2016
Published in Issue	Year 2016 Volume: 69 Issue: 3

Cite

APA	Kumbasar, U., Uysal, S., Şahinoğlu, T., … Önder, S. (2016). Gestational Trophoblastic Disease with Pulmonary and Cerebral Metastasis: Can Fluorodeoxyglucose Positron Emission Tomography Really Detect Cranial Metastatic Disease ? Ankara Üniversitesi Tıp Fakültesi Mecmuası, 69(3), 257-260.
AMA	Kumbasar U, Uysal S, Şahinoğlu T, Önder S, Demircin M. Gestational Trophoblastic Disease with Pulmonary and Cerebral Metastasis: Can Fluorodeoxyglucose Positron Emission Tomography Really Detect Cranial Metastatic Disease ? Ankara Üniversitesi Tıp Fakültesi Mecmuası. December 2016;69(3):257-260.
Chicago	Kumbasar, Ulaş, Serkan Uysal, Tuba Şahinoğlu, Sevgen Önder, and Metin Demircin. “Gestational Trophoblastic Disease With Pulmonary and Cerebral Metastasis: Can Fluorodeoxyglucose Positron Emission Tomography Really Detect Cranial Metastatic Disease ?”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 69, no. 3 (December 2016): 257-60.
EndNote	Kumbasar U, Uysal S, Şahinoğlu T, Önder S, Demircin M (December 1, 2016) Gestational Trophoblastic Disease with Pulmonary and Cerebral Metastasis: Can Fluorodeoxyglucose Positron Emission Tomography Really Detect Cranial Metastatic Disease ? Ankara Üniversitesi Tıp Fakültesi Mecmuası 69 3 257–260.
IEEE	U. Kumbasar, S. Uysal, T. Şahinoğlu, S. Önder, and M. Demircin, “Gestational Trophoblastic Disease with Pulmonary and Cerebral Metastasis: Can Fluorodeoxyglucose Positron Emission Tomography Really Detect Cranial Metastatic Disease ?”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 69, no. 3, pp. 257–260, 2016.
ISNAD	Kumbasar, Ulaş et al. “Gestational Trophoblastic Disease With Pulmonary and Cerebral Metastasis: Can Fluorodeoxyglucose Positron Emission Tomography Really Detect Cranial Metastatic Disease ?”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 69/3 (December2016), 257-260.
JAMA	Kumbasar U, Uysal S, Şahinoğlu T, Önder S, Demircin M. Gestational Trophoblastic Disease with Pulmonary and Cerebral Metastasis: Can Fluorodeoxyglucose Positron Emission Tomography Really Detect Cranial Metastatic Disease ? Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2016;69:257–260.
MLA	Kumbasar, Ulaş et al. “Gestational Trophoblastic Disease With Pulmonary and Cerebral Metastasis: Can Fluorodeoxyglucose Positron Emission Tomography Really Detect Cranial Metastatic Disease ?”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 69, no. 3, 2016, pp. 257-60.
Vancouver	Kumbasar U, Uysal S, Şahinoğlu T, Önder S, Demircin M. Gestational Trophoblastic Disease with Pulmonary and Cerebral Metastasis: Can Fluorodeoxyglucose Positron Emission Tomography Really Detect Cranial Metastatic Disease ? Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2016;69(3):257-60.