Iron Overload and Insulin Resistance in a Sample of Turkish Patients with Non-Alcoholic Steatohepatitis

Hale Gökcan; Yasemin Balaban; Halis Simsek; Engin Yılmaz; Gökhan Gedikoğlu; Gülsen Hasçelik; Gonca Tatar

Iron Overload and Insulin Resistance in a Sample of Turkish Patients with Non-Alcoholic Steatohepatitis

Abstract

Aim: We investigated the role of the H63D mutation on the development of hepatic iron overload and hepatic injury in non-alcoholic steatohepatitis patients and its association with insulin resistance and metabolic alterations. Material and Methods: Thirty-two patients with NASH, who were diagnosed at Hacettepe University Gastroenterology Outpatient Clinic depending on clinic and laboratory findings, were included into study. Metabolic syndrome was sought. Waist hip ratio and body mass index were calculated. H63D gene mutation, iron level at serum and liver biopsy specimens and histopathologic exam on liver biopsy specimens were studied in study group. Fasting and post-prandial blood sugar, lipid profile, 75-gr-glucose tolerance test and HOMA insulin resistance were measured to document the insulin resistance and metabolic syndrome. Results: Thirty-two patients with mean body mass index was 28.1 kg/m23,3 were included in study. Hypertension, obesity, hypercholesterolemia, hypertriglyceridemia, insulin resistance were found at 25 %, 37 %, 56 %, 28 % and 39 %, respectively. Serum ferritin and transferrin saturation values were within normal limits in all but except 2 patients. Hepatic iron concentration was ≥ 1600g in 12 (41%) of patients. H63D mutation was homozygote in 1 (3%) and heterozygote 12 (40%) patients. Therefore the H63D allele frequencies were 3.3% for homozygous, 20% for heterozygous and as total 23.4%. The patients with H63D mutation had normal serum and tissue iron parameters. There was no statistically significant relationship between H63D mutation and histopathological findings. Two hour blood sugar levels were higher in Stage 2 patients than in Stage 1 patients (p=0.05), and also higher in Class 4 patients than in Class ≤3 patients (p=0.05). Conclusion: The H63D mutation did not affected either serum iron parameters or histopathology. However, the insulin resistance was related with fibrosis in non-alcoholic steatohepatitis patients.

Keywords

HFE; H63D Mutation, Non-Alcoholic Steatohepatitis, Iron Overload, Insulin Resistance

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Details

Primary Language

English

Subjects

Gastroenterology Surgery

Journal Section

Research Article

Authors

Hale Gökcan
0000-0001-5663-0683
Türkiye

Yasemin Balaban
0000-0002-0901-9192
Türkiye

Halis Simsek
0000-0002-9306-557X
Türkiye

Engin Yılmaz
0000-0001-7765-430X
Türkiye

Gökhan Gedikoğlu This is me
0000-0001-8268-9662
Türkiye

Gülsen Hasçelik This is me
0000-0002-1773-6167
Türkiye

Gonca Tatar This is me
Türkiye

Publication Date

December 31, 2015

Submission Date

May 3, 2015

Acceptance Date

September 7, 2015

Published in Issue

Year 2015 Volume: 68 Number: 3

IZ

https://izlik.org/JA66ZZ89YT

APA

Gökcan, H., Balaban, Y., Simsek, H., Yılmaz, E., Gedikoğlu, G., Hasçelik, G., & Tatar, G. (2015). Iron Overload and Insulin Resistance in a Sample of Turkish Patients with Non-Alcoholic Steatohepatitis. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 68(3), 111-118. https://izlik.org/JA66ZZ89YT

AMA

1.Gökcan H, Balaban Y, Simsek H, et al. Iron Overload and Insulin Resistance in a Sample of Turkish Patients with Non-Alcoholic Steatohepatitis. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2015;68(3):111-118. https://izlik.org/JA66ZZ89YT

Chicago

Gökcan, Hale, Yasemin Balaban, Halis Simsek, et al. 2015. “Iron Overload and Insulin Resistance in a Sample of Turkish Patients With Non-Alcoholic Steatohepatitis”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 68 (3): 111-18. https://izlik.org/JA66ZZ89YT.

EndNote

Gökcan H, Balaban Y, Simsek H, Yılmaz E, Gedikoğlu G, Hasçelik G, Tatar G (December 1, 2015) Iron Overload and Insulin Resistance in a Sample of Turkish Patients with Non-Alcoholic Steatohepatitis. Ankara Üniversitesi Tıp Fakültesi Mecmuası 68 3 111–118.

IEEE

[1]H. Gökcan et al., “Iron Overload and Insulin Resistance in a Sample of Turkish Patients with Non-Alcoholic Steatohepatitis”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 68, no. 3, pp. 111–118, Dec. 2015, [Online]. Available: https://izlik.org/JA66ZZ89YT

ISNAD

Gökcan, Hale - Balaban, Yasemin - Simsek, Halis - Yılmaz, Engin - Gedikoğlu, Gökhan - Hasçelik, Gülsen - Tatar, Gonca. “Iron Overload and Insulin Resistance in a Sample of Turkish Patients With Non-Alcoholic Steatohepatitis”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 68/3 (December 1, 2015): 111-118. https://izlik.org/JA66ZZ89YT.

JAMA

1.Gökcan H, Balaban Y, Simsek H, Yılmaz E, Gedikoğlu G, Hasçelik G, Tatar G. Iron Overload and Insulin Resistance in a Sample of Turkish Patients with Non-Alcoholic Steatohepatitis. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2015;68:111–118.

MLA

Gökcan, Hale, et al. “Iron Overload and Insulin Resistance in a Sample of Turkish Patients With Non-Alcoholic Steatohepatitis”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 68, no. 3, Dec. 2015, pp. 111-8, https://izlik.org/JA66ZZ89YT.

Vancouver

1.Hale Gökcan, Yasemin Balaban, Halis Simsek, Engin Yılmaz, Gökhan Gedikoğlu, Gülsen Hasçelik, Gonca Tatar. Iron Overload and Insulin Resistance in a Sample of Turkish Patients with Non-Alcoholic Steatohepatitis. Ankara Üniversitesi Tıp Fakültesi Mecmuası [Internet]. 2015 Dec. 1;68(3):111-8. Available from: https://izlik.org/JA66ZZ89YT