Ovarian Sertoliform Endometrioid Adenocarcinoma: A Rare Variant Which Causes Diagnostic Pitfalls

Year 2015, Volume: 68 Issue: 3, 134 - 136, 31.12.2015

Duygu Kankaya , Korhan Kahraman Fırat Ortaç , Arzu Ensari

Abstract

Sertoliform endometrioid carcinoma (SEC) is a rare variant of endometrioid adenocarcinoma, which causes diagnostic pitfalls due to its morphologic resemblance of sex cord stromal tumors. Herein, we report a case of SEC in the ovary almost all of which consisted of sex-cord like areas and was presumed to be a sertoli cell tumour initially. Immunohistochemical features incompatible with sertoli cell tumour were alerting and extensive sampling revealed a focal component of classical endometrioid carcinoma with anastomosing cribriform areas of more columnar cells. The final diagnosis was sertoliform endometrioid adenocarcinoma. This entity should be kept in mind for all the pathologists and gynaecologic oncologists. Sampling such tumours extensively and confirming the diagnosis by immunohistochemistry using a large antibody panel is requisite for the correct diagnosis and preventing the patient from inappropriate therapies.

Keywords

Endometrioid Adenocarcinoma , Ovary , Sertoli Cell Tumour , Differential Diagnosis

Over Sertoliform Endometrioid Adenokarsinomu: Tanisal Tuzak Olușturan Nadir Bir Varyant

Abstract

Sertoliform endometrioid karsinoma (SEK), endometrioid adenokarsinomanın nadir görülen bir varyantı olup, seks kord stromal tümöre morfolojik benzerlikleri nedeniyle tanısal tuzak olușturur. Burada, neredeyse tamamı seks kord benzeri alanlardan olușan ve bașlangıçta sertoli hücreli tümör olarak düșünülen over SEK’sına ait bir olgu sunulmuștur. Sertoli hücreli tümör ile uyumlu olmayan immunohistokimyasal özellikler uyarıcı olmuș ve makroskopik olarak çok geniș örnekleme yapılmıștır, Fokal bir komponent olarak anastomozlașan kribriform alanlar meydana getiren daha kolumnar özellikte hücrelerle karakterli klasik endometrioid karsinoma alanlarının saptanması üzerine olgu sertoliform endometrioid adenokarsinoma olarak raporlanmıștır. Bu antitenin tüm patologlar ve jinekolojik onkologlar tarafından akılda tutulması gerekir. Bu tümörlerde doğru tanıya ulașılabilmesi ve dolayısıyla hastaların yanlıș tedavilerden korunabilmesi açısından, geniș makroskopik örneklemeyle inceleme yapılması ve geniș bir antikor paneliyle immunohistokimyasal doğrulama çok önemlidir

Keywords

Endometrioid Adenokarsinoma , Over , Sertoli Hücreli Tümör , Ayırıcı Tanı

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