Akut ST Yüksekliği Olmayan Miyokard İnfarktüsü Tanısında Erken Diyagnostik Belirteç Olarak Kalp Tipi Yağ Asidi Bağlayıcı Protein’in Kalitatif Ölçümünün, Diğer Kardiyak Belirteçler İle Karșılaștırılması
Abstract
Objective: Heart type fatty acid binding protein (H-FABP) is a new cardiac marker which is used in early diagosis (within the first two hours) of acute myocardial infarction (MI) and which shows myocyte injury. In our study, it was aimed to compare bed-side H-FABP measurement with routinely used CK-MB and troponin I for early diagnosis of non ST elevation MI (NSTEMI) and for determining its exclusion capacity.
Material and Method: A total of 48 patients who were admitted to emergency room with ischemic type chest pain lasting for more than 30 minute within the first 12 hours and who did not have ST segment elevation on electrocardigraphy (ECG) were included in the study. Definite diagnosis of NSTEMI was made in 24 patients as the result of 24-hour follow up, remaining 24 patients did not develop MI.
Results: When various subgroups were analysed according to admission hours, H-FABP was detected to be a beter diagnostic marker (accuracy 85%) comparedto CK-MB and troponin with high sensitivity (79%) and specifity (93%) in early diagnosis (≤6 hours) (p<0,05).
Conclusion: Bed-side H-FABP measurement may be considered to contribute to correct and early diagnosis as it elevated early following MI, its measurement is easy and it provides a rapid result.
Keywords
Acute Coronary syndrome, Non ST Elevation Myocardial Infarction, H-FABP, CK-MB, troponin
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