Profilaktik Mastektomide Meme Rekonstrüksiyonu

Abstract

It has become evident that breast cancer; the leading cause of morbidity and mortality in women; can be prevented in some cases due to the increasing social awareness, BRCA1 and BRCA2 gene mutation analysis and developing risk reduction strategies. Prophylactic mastectomy, which happens to be one of those strategies, is found to reduce the risk of cancer development by 85-90 % in high-risk patients. Analysis of the genes leaves the surgeons with a population at an early age that gives importance to the integrity of the body image and demands breast reconstruction as soon as possible. However; breast reconstruction after prophylactic mastectomy bears some distinct features. For this reason, a multidisciplinary approach should be followed and the timing of surgical procedure, type of mastectomy to be applied, reconstruction options for each patient, possible complications should be discussed in details before the surgery. This study defines the differences and the importance of reconstruction after prophylactic mastectomy

Keywords

• Breast cancer
• BRCA 1-2
• Prophylactic
• Mastectomy
• Breast reconstruction
• Implant
• Autologous.

Profilaktik Mastektomide Meme Rekonstrüksiyonu

Abstract

Kadınlarda morbidite ve mortalite nedenlerinden bașı çeken meme kanserinin; artan toplumsal bilinç, BRCA1 ve BRCA2 gen mutasyon analizlerinin hız kazanması ve risk azaltıcı stratejilerin geliștirilmesiyle bazı olgularda önlenebilir olduğu netlik kazanmıștır. Yüksek risk tașıdığı tespit edilen bu hastalarda risk azaltıcı tekniklerden profilaktik mastektominin bilateral uygulandığı olgularda meme kanseri gelișme riskini yaklașık %85-90 düșürdüğü gösterilmiștir. Gelișen gen analizleri ile erken yașta tespit edilen ve vücut görünümünün bütünlüğüne önem veren yüksek riskli bu populasyonun profilaktik mastektomi sonrasında meme rekonstrüksiyonu isteği giderek artmaktadır. Ancak profilaktik mastektomi sonrası meme rekonstrüksiyonu bazı özellikler tașımaktadır. Bu nedenle hastalar multidisipliner bir yöntemle incelenmeli; cerrahi ișlemin zamanlaması, uygulanacak mastektomi tipi, (her hasta için kișiselleștirilmiș) rekonstrüksiyon seçenekleri, olușabilecek komplikasyonlar ameliyat öncesi ayrıntılarıyla konușulmalıdır. Bu çalıșmada profilaktik mastektomi sonrası rekonstrüksiyonunun önemi ve farklılıkları açıklanmıștır.

Keywords

• Meme kanseri
• BRCA 1-2
• Profilaktik
• Mastektomi
• Meme rekonstrüksiyonu
• İmplant
• Otolog

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