Ga-68 DOTATATE Positron Emission Tomography Computed Tomography Findings in Patients with Neuroendocrine Tumor Suspicion

Year 2016, Volume: 69 Issue: 1, 7 - 10, 03.06.2016

Çiğdem Soydal , Elgin Özkan , Evrim Bali Ataş Nuriye Özlem Küçük , Metin Kemal Kır

Abstract

Aim: We aimed to retrospectively evaluate the outcome of patients with suspected neuroendocrine tumor (NET)s who underwent Ga-68 DOTATATE Pozitrun Emission Tomography/Computed Tomography (PET/CT) imaging and to describe the value of Ga-68 DOTATATE PET/CT in the detection of NETs.

Material and Method: Ga-68 DOTATATE PET/CT images of 35 patients (26M; 9F, mean age; 45.2±5.4 years) with suspected NET were analyzed retrospectively. Suspicion of NET was due to clinical symptoms (n:12), elevated biochemical markers (n:19) and/or radiological findings (n:13). Clinical/imaging follow-up and/or histopathological
confirmation was used as reference standard.

Results: Based on the reference standard 13 of 35 patients had NET. Ga-68 DOTATATE PET/CT was positive in 12 out of 13 patients and it was false negative in 1 patient. Pancreas was the commonest site of the primary tumor. Ga-68 DOTATATE was TP(true pozitive), FP (False Positive), TN (True Negative) and FN (False Negative) in, 12, 2, 20 and 1, patients respectively. Sensitivity, specificity, Pozitive Pedictive Value (PPV), Negative Pedictive Value (NPV), and accuracy of Ga-68 DOTATATE PET/CT was calculated as 85%, 95%, 92%, 90% and 91%, respectively.

Conclusion: Ga-68 DOTATATE PET/CT has a high accuracy in the detection of suspected NET. It can be used for searching possible NET in patients with suspicion.

Keywords

Neuroendocrine Tumor , Ga-68 DOTATATE , PET/CT

Ethical Statement

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Nöroendokrin Tümör 􀄸üphesi Olan Hastalarda Ga-68 DOTATATE Pozitron Emisyon Tomografisi/Bilgisayarl Tomografi Bulgular

Abstract

Amaç: Nöroendokrin Tümör (NET) 􀄹üphesi ile Ga-68 DOTATATE Pozitron Emisyon Tomografisi/Bilgisayarl Tomografi (PET/BT) görüntüleme yaplan hastalarn sonuçlarn retrospektif olarak de􀃾erlendirmeyi ve NET saptanmasnda Ga- 68 DOTATATE PET/BT’nin yerini tanmlamay amaçladk.

Gereç ve Yöntem: Nöroendokrin tumor 􀄹üphesi ile Ga-68 DOTATATE PET/BT yaplan 35 hastann (26E; 9K, ort. ya􀄹; 45.2±5.4) sonuçlar retrospektif olarak analiz edildi. Nöroendokrin tumor 􀄹üphesi klinik bulgular (n:12), biyokimyasal parametrelerde yükselme (n:19) ve radyolojik bulgular (n:13) idi. Klinik/radyolojik takip ve/veya histopatolojik inceleme referans standart olarak kullanld.

Bulgular: Referans standart temel alnarak 35 hastann 13’ü NET olarak kabul edildi. Ga-68 DOTATATE PET/BT 13 hastann 12’sinde pozitif ve 1’inde yalanc negative idi. En sk primer tümör lokalizayonu pankreas idi. Ga-68 DOTATATE PET/BT 12, 2, 20 and 1 hastada sras ile Gerçek Pozitif (GP), Yalanc Pozitif (YP), Gerçek Negatif (GN) ve
Yalanc Negatif (YN) idi. Ga-68 DOTATATE PET/BT için duyarllk, özgüllük, pozitif pediatrig de􀃾er, negatif pediatrik de􀃾er ve do􀃾ruluk sras ile %85, %95, %92, %90 ve %91% olarak hesapland.

Sonuç: Ga-68 DOTATATE PET/BT NET 􀄹üphesinde tümör oda􀃾nn saptanmasnda yüksek do􀃾rulu􀃾a sahiptir ve bu amaçla kullanlabilir.

Keywords

Nöroendokrin Tümör , Ga-68 DOTATATE , PET/BT

Ethical Statement

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Supporting Institution

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Project Number

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Thanks

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