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The Relation Between the Severity of Androgenetic Alopecia and Cardiovascular Atherosclerosis Measured Via Carotid Intima-Media Thickness and the Syntax Score

Year 2016, Volume: 69 Issue: 2, 101 - 106, 20.10.2016

Abstract

Objectives: We aimed to search the relation between androgenetic alopecia (AGA) and cardiovascular atherosclerosis measured via carotid intima-media thickness (CIMT) and the SYNTAX score.

Material-Methods: One hundred and sixteen subjects with an indication for coronary angiography were prospectively enrolled into the study. AGA was classified according to the Hamilton baldness scale (for males) and Ludwig scale (for females). Subjects were separated into three groups according to degree of their baldness scale. The SYNTAX score and CIMT were measured for each subject accordingly. Analyses of male and female subjects were carried out separately.

Results: For male subjects; group 3 (n=15) had significantly higher SYNTAX score compared to group 1 (n=14) and group 2 (n=35). Similarly for female subjects, group 3 (n=12) had significantly higher SYNTAX score compared to group 1 (n=29) and group 2 (n=14). Among both male and female subjects, CIMT of group 3 were significantly higher than that of other groups.

Conclusion: AGA may be a simple phenotypical indicator for cardiovascular atherosclerosis since we found that patients with higher stage of AGA had significantly higher SYNTAX score and CIMT value among both gender.

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References

  • 1. Stough D, Stenn K, Haber R, et al. Psychological effect, pathophysiology, and management of androgenetic alopecia in men.Mayo Clin Proc. 2005;80:1316-1322.
  • 2. Piraccini BM, Alessandrini A. Androgenetic alopecia.G Ital Dermatol Venereol. 2014;149:15-24.
  • 3. Hogan DJ, Chamberlain M. Male pattern baldness.South Med J. 2000;93:657-662.
  • 4. Sharma KH, Jindal A. Association between androgenetic alopecia and coronary artery disease in young male patients. Int J Trichology. 2014;6:5-7.
  • 5. Traish AM. Adverse health effects of testosterone deficiency (TD) in men. Steroids. 2014;88:106-16.
  • 6. Agac MT, Bektas H, Korkmaz L, et al. Androgenetic alopecia is associated with increased arterial stiffness in asymptomatic young adults. J Eur Acad Dermatol Venereol. 2014 Mar 14. doi: 10.1111/jdv.12424. [Epub ahead of print].
  • 7. Vigen R, O’Donnell CI, Barón AE, et al. Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels. JAMA. 2013;310:1829–1836
  • 8. Herskovitz I, Tosti A. Female pattern hair loss. Int J Endocrinol Metab. 2013;11:e9860.
  • 9. Stein JH, Korcarz CE, Hurst RT, et al. American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima- Media Thickness Task Force. Endorsed by the Society for Vascular Medicine. J Am Soc Echocardiogr. 2008;21:93-111.
  • 10. Sianos G, Morel MA, Kappetein AP, et al. The SYNTAX score: an angiographic tool grading the complexity of coronary artery disease. Euro Intervention 2005;1:219–227.
  • 11. Grober ED. Testosterone deficiency and replacement: Myths and realities. Can Urol Assoc J. 2014;8:S145-147.
  • 12. Norwood OT. Male pattern baldness: classification and incidence. South Med J 1975;68: 1359–1365.
  • 13. Erkoç MF, Çölgeçen E, Ede H, et al. Correlation Of Carotid Intima Media Thickness And Aortic Stiffness Index With Androgenetic Alopecia. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2015;68:9-14.
  • 14. Ludwig E. Classification of the types of androgenetic alopecia (common baldness) occurring in the female sex. Br J Dermatol. 1977;97:247-254.
  • 15. Trieu N, Eslick GD. Alopecia and its association with coronary heart disease and cardiovascular risk factors: a metaanalysis. Int J Cardiol. 2014;176:687-695.
  • 16. Arias-Santiago S, Gutiérrez-Salmerón MT, Castellote-Caballero L, et al. Androgenetic alopecia and cardiovascular risk factors in men and women: a comparative study. J Am Acad Dermatol. 2010;63:420-429.,
  • 17. Ahouansou S, Le Toumelin P, Crickx B, et al. Association of androgenetic alopecia and hypertension. Eur J Dermatol. 2007;17:220-222.
  • 18. Sianos G, Morel MA, Kappetein AP, et al. The SYNTAX score: an angiographic tool grading the complexity of coronary artery disease. EuroIntervention 2005;1:219–27.
  • 19. Yadav M, Palmerini T, Caixeta A, et al. Prediction of coronaryrisk by SYNTAX and derivedscores: synergy between percutaneous coronary intervention with taxus and cardiac surgery. J Am Coll Cardiol. 2013;62:1219-1230.
  • 20. Vayá A, Sarnago A, Ricart JM, et al. Inflammatory markers and Lp(a) levels as cardiovascular risk factors in androgenetic alopecia. Clin Hemorheol Microcirc. 2016;61:471-477.
  • 21. Rebora A. Baldness and coronary artery disease: the dermatologic point of view of a controversial issue. Arch Dermatol. 2001;137:943-947.
  • 22. Bakry OA, Shoeib MA, El Shafiee MK, et al. Androgenetic alopecia, metabolic syndrome, and insulin resistance: Is there any association? A case-control study. Indian Dermatol Online J. 2014; 5:276-281.
  • 23. Mirmirani P. Age-related hair changes in men: Mechanisms and management of alopecia and graying. Maturitas. 2014 Oct 23. doi: 10.1016/j.maturitas.2014.10.008. [Epub ahead of print].
  • 24. Korkmaz L, Bektas H, Korkmaz AA, et al. Increased carotid intima-media thickness is associated with higher SYNTAX score. Angiology. 2012;63:386-389.

Androgenetik Alopesi Ciddiyeti ile Karotid İntima-Media Kalınlığı ve SYNTAX skoru ile ölçülen Kardiyovasküler Ateroskleroz İlișkisi

Year 2016, Volume: 69 Issue: 2, 101 - 106, 20.10.2016

Abstract

Amaç: Androgenetik alopesi (AGA) ile karotid intima-media kalınlığı (KİMK) ve SYNTAX skoru ile ölçülenkardiyovasküler ateroskleroz arasındaki ilișkiyi araștırmayı amaçladık.

Gereç ve Yöntem: Koroner anjiyografi endikasyonu konulmuș yüz onaltı hasta prospektif olarak çalıșmaya dahil edildi. Hamilton kellik skalası (erkekler için) ve Ludwig kellik skalası (kadınlar için) kullanılarak AGA sınıflandırıldı. Hastalar, kellik skala derecelerine göre üç gruba ayrıldı. Her bir hastanın SYNTAX skoru ve KİMK değeri uygun biçimde ölçüldü. Kaın ve erkek hastaların verileri ayrı ayrı değerlendirildi.

Bulgular: Erkeklerde; 3. grup (n=15), 1. gruba (n=14) ve 2. gruba (n=35) göre belirgin biçimde daha yüksek SYNTAX skoruna sahipti. Benzer șekilde, kadınlarda da 3. grup (n=12), 1. gruba (n=29) ve 2. gruba (n=14) göre belirgin biçimde daha yüksek SYNTAX skoruna sahipti. Hem kadınlarda hem de erkeklerde 3. grup diğerlerine göre daha yüksek KİMK değerine sahipti.

Sonuç: Androgenetik alopesi, kardiyovasküler aterosklerozun basit bir göstergesi olabilir çünkü her iki cinsiyettede yüksek AGA seviyelerine sahip olan hastalar belirgin olarak daha yüksek SYNTAX skoruna ve KIMK değerine sahip olduğunu bulduk.

Project Number

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References

  • 1. Stough D, Stenn K, Haber R, et al. Psychological effect, pathophysiology, and management of androgenetic alopecia in men.Mayo Clin Proc. 2005;80:1316-1322.
  • 2. Piraccini BM, Alessandrini A. Androgenetic alopecia.G Ital Dermatol Venereol. 2014;149:15-24.
  • 3. Hogan DJ, Chamberlain M. Male pattern baldness.South Med J. 2000;93:657-662.
  • 4. Sharma KH, Jindal A. Association between androgenetic alopecia and coronary artery disease in young male patients. Int J Trichology. 2014;6:5-7.
  • 5. Traish AM. Adverse health effects of testosterone deficiency (TD) in men. Steroids. 2014;88:106-16.
  • 6. Agac MT, Bektas H, Korkmaz L, et al. Androgenetic alopecia is associated with increased arterial stiffness in asymptomatic young adults. J Eur Acad Dermatol Venereol. 2014 Mar 14. doi: 10.1111/jdv.12424. [Epub ahead of print].
  • 7. Vigen R, O’Donnell CI, Barón AE, et al. Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels. JAMA. 2013;310:1829–1836
  • 8. Herskovitz I, Tosti A. Female pattern hair loss. Int J Endocrinol Metab. 2013;11:e9860.
  • 9. Stein JH, Korcarz CE, Hurst RT, et al. American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima- Media Thickness Task Force. Endorsed by the Society for Vascular Medicine. J Am Soc Echocardiogr. 2008;21:93-111.
  • 10. Sianos G, Morel MA, Kappetein AP, et al. The SYNTAX score: an angiographic tool grading the complexity of coronary artery disease. Euro Intervention 2005;1:219–227.
  • 11. Grober ED. Testosterone deficiency and replacement: Myths and realities. Can Urol Assoc J. 2014;8:S145-147.
  • 12. Norwood OT. Male pattern baldness: classification and incidence. South Med J 1975;68: 1359–1365.
  • 13. Erkoç MF, Çölgeçen E, Ede H, et al. Correlation Of Carotid Intima Media Thickness And Aortic Stiffness Index With Androgenetic Alopecia. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2015;68:9-14.
  • 14. Ludwig E. Classification of the types of androgenetic alopecia (common baldness) occurring in the female sex. Br J Dermatol. 1977;97:247-254.
  • 15. Trieu N, Eslick GD. Alopecia and its association with coronary heart disease and cardiovascular risk factors: a metaanalysis. Int J Cardiol. 2014;176:687-695.
  • 16. Arias-Santiago S, Gutiérrez-Salmerón MT, Castellote-Caballero L, et al. Androgenetic alopecia and cardiovascular risk factors in men and women: a comparative study. J Am Acad Dermatol. 2010;63:420-429.,
  • 17. Ahouansou S, Le Toumelin P, Crickx B, et al. Association of androgenetic alopecia and hypertension. Eur J Dermatol. 2007;17:220-222.
  • 18. Sianos G, Morel MA, Kappetein AP, et al. The SYNTAX score: an angiographic tool grading the complexity of coronary artery disease. EuroIntervention 2005;1:219–27.
  • 19. Yadav M, Palmerini T, Caixeta A, et al. Prediction of coronaryrisk by SYNTAX and derivedscores: synergy between percutaneous coronary intervention with taxus and cardiac surgery. J Am Coll Cardiol. 2013;62:1219-1230.
  • 20. Vayá A, Sarnago A, Ricart JM, et al. Inflammatory markers and Lp(a) levels as cardiovascular risk factors in androgenetic alopecia. Clin Hemorheol Microcirc. 2016;61:471-477.
  • 21. Rebora A. Baldness and coronary artery disease: the dermatologic point of view of a controversial issue. Arch Dermatol. 2001;137:943-947.
  • 22. Bakry OA, Shoeib MA, El Shafiee MK, et al. Androgenetic alopecia, metabolic syndrome, and insulin resistance: Is there any association? A case-control study. Indian Dermatol Online J. 2014; 5:276-281.
  • 23. Mirmirani P. Age-related hair changes in men: Mechanisms and management of alopecia and graying. Maturitas. 2014 Oct 23. doi: 10.1016/j.maturitas.2014.10.008. [Epub ahead of print].
  • 24. Korkmaz L, Bektas H, Korkmaz AA, et al. Increased carotid intima-media thickness is associated with higher SYNTAX score. Angiology. 2012;63:386-389.
There are 24 citations in total.

Details

Primary Language English
Subjects Cardiology, Dermatology, Diagnostic Radiography
Journal Section Research Article
Authors

Hüseyin Ede 0000-0003-1218-257X

Emine Çölgeçen 0000-0001-9651-6068

Mustafa Fatih Erkoç This is me 0000-0002-6266-5177

Yurdanur Akyüz 0000-0002-4070-6652

Ali Rıza Elbay This is me 0009-0008-1117-2170

Project Number -
Publication Date October 20, 2016
Published in Issue Year 2016 Volume: 69 Issue: 2

Cite

APA Ede, H., Çölgeçen, E., Erkoç, M. F., … Akyüz, Y. (2016). The Relation Between the Severity of Androgenetic Alopecia and Cardiovascular Atherosclerosis Measured Via Carotid Intima-Media Thickness and the Syntax Score. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 69(2), 101-106.
AMA Ede H, Çölgeçen E, Erkoç MF, Akyüz Y, Elbay AR. The Relation Between the Severity of Androgenetic Alopecia and Cardiovascular Atherosclerosis Measured Via Carotid Intima-Media Thickness and the Syntax Score. Ankara Üniversitesi Tıp Fakültesi Mecmuası. October 2016;69(2):101-106.
Chicago Ede, Hüseyin, Emine Çölgeçen, Mustafa Fatih Erkoç, Yurdanur Akyüz, and Ali Rıza Elbay. “The Relation Between the Severity of Androgenetic Alopecia and Cardiovascular Atherosclerosis Measured Via Carotid Intima-Media Thickness and the Syntax Score”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 69, no. 2 (October 2016): 101-6.
EndNote Ede H, Çölgeçen E, Erkoç MF, Akyüz Y, Elbay AR (October 1, 2016) The Relation Between the Severity of Androgenetic Alopecia and Cardiovascular Atherosclerosis Measured Via Carotid Intima-Media Thickness and the Syntax Score. Ankara Üniversitesi Tıp Fakültesi Mecmuası 69 2 101–106.
IEEE H. Ede, E. Çölgeçen, M. F. Erkoç, Y. Akyüz, and A. R. Elbay, “The Relation Between the Severity of Androgenetic Alopecia and Cardiovascular Atherosclerosis Measured Via Carotid Intima-Media Thickness and the Syntax Score”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 69, no. 2, pp. 101–106, 2016.
ISNAD Ede, Hüseyin et al. “The Relation Between the Severity of Androgenetic Alopecia and Cardiovascular Atherosclerosis Measured Via Carotid Intima-Media Thickness and the Syntax Score”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 69/2 (October2016), 101-106.
JAMA Ede H, Çölgeçen E, Erkoç MF, Akyüz Y, Elbay AR. The Relation Between the Severity of Androgenetic Alopecia and Cardiovascular Atherosclerosis Measured Via Carotid Intima-Media Thickness and the Syntax Score. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2016;69:101–106.
MLA Ede, Hüseyin et al. “The Relation Between the Severity of Androgenetic Alopecia and Cardiovascular Atherosclerosis Measured Via Carotid Intima-Media Thickness and the Syntax Score”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 69, no. 2, 2016, pp. 101-6.
Vancouver Ede H, Çölgeçen E, Erkoç MF, Akyüz Y, Elbay AR. The Relation Between the Severity of Androgenetic Alopecia and Cardiovascular Atherosclerosis Measured Via Carotid Intima-Media Thickness and the Syntax Score. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2016;69(2):101-6.