Amniocentesis Results According to Risk Factors: A Result of 1026 Women With Advanced Maternal Age

Year 2016, Volume: 69 Issue: 1, 49 - 52, 03.06.2016

Tuncay Yüce , Erkan Kalafat , Batuhan Özmen , Acar Koç , Feride Söylemez

Abstract

Aim: To compare amniocentesis results of women above age of 35 according to their risk factors (maternal age alone vs maternal age and biochemical risk)

Method: This was a retrospective cohort study including a population of pregnant women who underwent amniocentesis between years 2006 and 2014. Women were grouped into two according to their risk factor (age alone vs age and biochemical risk). Abnormal amniocentesis results were compared among groups.

Results: 702 women with only maternal age risk and 324 women with combined age and biochemical risk were included in study (1026 in total). Mean age of the study population was 38,11±2,66. Biochemical risk group had 27 fetuses (8,3%) with Trisomy 21 while advanced age only risk group had 18 fetuses (2,5%) diagnosed with Trisomy 21. When added to age factor, biochemical factors increased detection of Trisomy 21 significantly (Odds ratio : 3,56 p <0,001 ).

Conclusion: Advanced maternal age alone can be used to detect a small percentage of chromosomal abnormality cases, and its use as an indication for invasive procedures should be at clinician’s discretion along with patient consent. Biochemical factors added to maternal age risk increases detection rates and combined risk offers a more solid indication for invasive procedures

Keywords

Amniocentesis , Advanced Maternal Age , Biochemical Factors

Ethical Statement

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