Research Article

Amniocentesis Results According to Risk Factors: A Result of 1026 Women With Advanced Maternal Age

Volume: 69 Number: 1 June 3, 2016
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Ankara Üniversitesi Tıp Fakültesi Mecmuası
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Amniocentesis Results According to Risk Factors: A Result of 1026 Women With Advanced Maternal Age

Abstract

Aim: To compare amniocentesis results of women above age of 35 according to their risk factors (maternal age alone vs maternal age and biochemical risk) Method: This was a retrospective cohort study including a population of pregnant women who underwent amniocentesis between years 2006 and 2014. Women were grouped into two according to their risk factor (age alone vs age and biochemical risk). Abnormal amniocentesis results were compared among groups. Results: 702 women with only maternal age risk and 324 women with combined age and biochemical risk were included in study (1026 in total). Mean age of the study population was 38,11±2,66. Biochemical risk group had 27 fetuses (8,3%) with Trisomy 21 while advanced age only risk group had 18 fetuses (2,5%) diagnosed with Trisomy 21. When added to age factor, biochemical factors increased detection of Trisomy 21 significantly (Odds ratio : 3,56 p <0,001 ). Conclusion: Advanced maternal age alone can be used to detect a small percentage of chromosomal abnormality cases, and its use as an indication for invasive procedures should be at clinician’s discretion along with patient consent. Biochemical factors added to maternal age risk increases detection rates and combined risk offers a more solid indication for invasive procedures

Keywords

References

  1. 1.􀀃 Goddijn M, Joosten JH, Knegt AC, et al. Clinical relevance of diagnosing structural chromosome abnormalities in couples with repeated miscarriage. Hum Reprod. 2004;19:1013-1017.
  2. 2.􀀃 Balkan M, Akbas H, Kalkanli S, et al. Evaluation of clinical and cytogenetic findings on 1,068 second-trimester amniocenteses in Southeast Turkey. Clin Exp Obstet Gynecol. 2011;38:364-368.
  3. 3.􀀃 Karao􀃸uz MY, Bal F, Yakut T, et al. Cytogenetic results of amniocentesis materials: incidence of abnormal karyotypes in the Turkish collaborative study. Genet Couns. 2006;17:219-230.
  4. 4.􀀃 Bottalico JN, Chen X, Tartaglia M, et al. Second-trimester genetic sonogram for detection of fetal chromosomal abnormalities in a community-based antenatal testing unit.Ultrasound Obstet Gynecol. 2009;33:161-168
  5. 5.􀀃 Qi QW, Jiang YL, Zhou XY, et al. Genetic counseling, prenatal screening and diagnosis of Down syndrome in the second trimester in women of advanced maternal age: a prospective study. Chin Med J. 2013;126(11):2007-2010.
  6. 6.􀀃 Han SH, An JW, Jeong GY et al. Clinical and cytogenetic findings on 31,615 midtrimester amniocenteses. Korean J Lab Med. 2008; 28: 378–385.􀍒
  7. 7.􀀃 Chang YH, Chen PY, Li TY, et al. Discrepancy of cytogenetic analysis in Western and Eastern Taiwan. Pediatric Neonatology 2013;54:161–165.
  8. 8.􀀃 Ocak Z, Ozlü T, Yazcog􀡅lu HF, Ozyurt O, Aygün M. Clinical and cytogenetic results of a large series of amniocentesis cases from Turkey: report of 6124 cases. Journal of Obstetrics and Gynaecology Research 2013;40:139–146.

Details

Primary Language

English

Subjects

Obstetrics and Gynaecology

Journal Section

Research Article

Authors

Publication Date

June 3, 2016

Submission Date

June 12, 2015

Acceptance Date

March 3, 2016

Published in Issue

Year 2016 Volume: 69 Number: 1

IZ

https://izlik.org/JA68JT33KY

Cite

RIS / Bibtex
APA
Yüce, T., Kalafat, E., Özmen, B., Koç, A., & Söylemez, F. (2016). Amniocentesis Results According to Risk Factors: A Result of 1026 Women With Advanced Maternal Age. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 69(1), 49-52. https://izlik.org/JA68JT33KY
AMA
1.Yüce T, Kalafat E, Özmen B, Koç A, Söylemez F. Amniocentesis Results According to Risk Factors: A Result of 1026 Women With Advanced Maternal Age. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2016;69(1):49-52. https://izlik.org/JA68JT33KY
Chicago
Yüce, Tuncay, Erkan Kalafat, Batuhan Özmen, Acar Koç, and Feride Söylemez. 2016. “Amniocentesis Results According to Risk Factors: A Result of 1026 Women With Advanced Maternal Age”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 69 (1): 49-52. https://izlik.org/JA68JT33KY.
EndNote
Yüce T, Kalafat E, Özmen B, Koç A, Söylemez F (June 1, 2016) Amniocentesis Results According to Risk Factors: A Result of 1026 Women With Advanced Maternal Age. Ankara Üniversitesi Tıp Fakültesi Mecmuası 69 1 49–52.
IEEE
[1]T. Yüce, E. Kalafat, B. Özmen, A. Koç, and F. Söylemez, “Amniocentesis Results According to Risk Factors: A Result of 1026 Women With Advanced Maternal Age”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 69, no. 1, pp. 49–52, June 2016, [Online]. Available: https://izlik.org/JA68JT33KY
ISNAD
Yüce, Tuncay - Kalafat, Erkan - Özmen, Batuhan - Koç, Acar - Söylemez, Feride. “Amniocentesis Results According to Risk Factors: A Result of 1026 Women With Advanced Maternal Age”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 69/1 (June 1, 2016): 49-52. https://izlik.org/JA68JT33KY.
JAMA
1.Yüce T, Kalafat E, Özmen B, Koç A, Söylemez F. Amniocentesis Results According to Risk Factors: A Result of 1026 Women With Advanced Maternal Age. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2016;69:49–52.
MLA
Yüce, Tuncay, et al. “Amniocentesis Results According to Risk Factors: A Result of 1026 Women With Advanced Maternal Age”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 69, no. 1, June 2016, pp. 49-52, https://izlik.org/JA68JT33KY.
Vancouver
1.Tuncay Yüce, Erkan Kalafat, Batuhan Özmen, Acar Koç, Feride Söylemez. Amniocentesis Results According to Risk Factors: A Result of 1026 Women With Advanced Maternal Age. Ankara Üniversitesi Tıp Fakültesi Mecmuası [Internet]. 2016 Jun. 1;69(1):49-52. Available from: https://izlik.org/JA68JT33KY