Immünopathogenenis of Multiple Sclerosis Part 2: The beginning and rise of the disease

Abstract

İlk kısımda multipl sklerozisli bir hastanın MR görüntülemesinde gördüğümüz bütün plakların aynı anlama gelmediğinden, hastalar arası farklar olduğundan ve konvansiyonel MR görüntülerde göremesek de, kortekste de plaklar olduğundan bahsedilmiști. İkinci kısımda ise, önce hastalığın doğușu ve yükseliși ile ilgili hayvan modellerinin in vivo görüntülemesiyle elde edilmiș veriler sunulacak, sonra da hasta takibinde kullanılan konvansiyonel ve nonkonvansiyonel MR görüntülerinden șimdiye kadar öğrendiklerimiz ve bu görüntüleme yönteminin kısıtlılıklarından bahsedilecektir. Bu bölümün sonunda, multipl sklerozis tedavisinde kullanılmakta olan ve/veya ileride kullanılabilecek ilaçların bazılarının tedavi mekanizmaları hakkında bilgi sahibi olunması ve hasta takibinde birincil rol oynayan MR görüntülerinin daha bilinçli olarak yorumlanır hale gelinmesi hedeflenmektedir.

Keywords

• : Multipl Skleroz
• Patogenez
• İmmünoloji
• Deney Modeli
• Manyetik Rezonans Görüntüleme

Multipl Sklerozisin İmmünpatogenezi Kısım 2: Hastalığın doğușu ve yükseliși

Abstract

In the first part of this review, we described that plaques that we see on MRI are not all the same, there are different plaque patterns between patients and although we cannot detect with conventional MRI, there are cortical plaques in almost all of the patients. In the second part, we will first concentrate on the first phase of disease. We will explain the data that we learned by in vivo imaging of animal models. Thereafter, we will review what we have learned from conventional and non-conventional MRI imaging, and discuss the shortcomings of these methods. After the completion of this section, we hope that readers will have knowledge on the mechanisms of some of the most widely used therapeutic agents and will be able to interpret MR images of MS patients more efficiently

Keywords

• : Multiple Sclerosis
• Pathogenesis
• Immunology
• Disease Model
• Magnetic Resonance Imaging

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