The Permeahility Increase Mechanisms of Blood-Brain Barrier

Abstract

İt is known that the permeability of bjood-brain barrier (BBB) againts the proteins is very Iow. Main reason for this Iow permeability is the existence of tight junctions between brain endothelial cells, a fcw pinocytotic activity and absence of fenestrae. However, during ArtbsSL Meleanizmalarl pathologic cases like ischemia, cold injury, acute hypertension and seizure activity, BBB breaks down. The reason for the permeability increace against the proteins on the BBB, is found to be the pinocytotic activity increase, and the role of various factors from histamine to the products of arachidonic acid metabolism has been studied. In the presented review, the relationship between histamine releasing, arachi-donic acid metabolism and oxidant stress, which lead to increase of BBB permeability is discussed.

Keywords

• Blood-brain barrier
• histamine
• oxidant stress
• prostaglandins
• hypertension
• seizure

KAN-BEYİN BARİYERİ PERMEABİLİTE ARTIŞI MEKANİZMALARI

Abstract

Kan beyin bariyeri (KBB)nin proteinlere karşı permeabilitesinin çok düşük olduğu bilinmektedir. Bu düşük permeabilite; beyin kapiller endotel hücreleri arasında bulunan sıkı fenestraların yokluğuna ve pinositotik aktivitenin düşüklüğüne bağlanmıştır. Ancak iskemi, soğuk yaralanması, akut hipertansiyon ve konvülsiyonlar gibi patolojik olaylar esnasında KBB'i yıkılmaktadır. KBB'de proteinlere karşı artmış permeabilitedenj pinositotik aktivite artışı sorumlu tutulmuş ve histaminden araşidonik asit metabolizması ürünlerine kadar çeşitli faktörlerin rolü incelenmiştir. Sunulan derlemede, KBB permeabilite artışına yol açan, histamin salınımı, araşidonik asit metabolizması ve oksidan stres arasındaki ilişki tartışılmıştır.

Keywords

• : Kan-beyin bariyeri
• Pinositotik aktivite
• histamin
• oksidan stres
• Drostaglandinler
• hipertansiyon
• epileptik atak.

References

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