Role of the Free Oxygen Radicals on the Occurance of Hyperbaric Bradycardia.

Year 1993, Volume: 46 Issue: 3, 515 - 526, 30.09.1993

Metin Baştuğ

Abstract

One of the changes that observed in human and animals who are
exposed to high pressure is the decrease of the heart rate and is called as «hyperbaric bradycardia». Specific reflex mechanisms, progressive hypoxia and hypercapnia have been claimed to be efficient
factors on the pathogenesis of hyperboaric bradycardia but it has been
proved that the increase of vagal activity is of no importance and reflex mechanisms haven’t played a major role. In hyperbaric environment, a decrease in erythrocyte SOD activity, an increase in lipid peroxidation products, and an existence of correlation between variousmembran phospholipid amounts and bradycardic response have been
established. In this study the preadministration of SOD + Catalase
and allopurinol prevented occurance of hyperbaric bradycardia. These findings have shown that free oxygen radicals have a role in the
pathogenesis of hyperbaric bradycardia and the primer source of free
oxygen radicals might be due to the increase in xanthine oxidase acitivity.

Keywords

allopurinol , antioxidants , atmospheric pressure , bradyceardia , catalase , diving , hyperbaric oxygenation , superoxide dismutase , xanthine oxidase.

Project Number

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Hiperbarik Bradikardt Olugumunda Serbest Okstjen

Abstract

Ytiksek basinca maruz kalan insan ve hayvanlarda gézlenen degisikliklerden birisi kalp frekansinda azalmadir ve «hiperbarik bradikardi» olarak isimlendirilmistir. Hiperbarik bradikardinin patogenezinde etkin faktorler olarak spesifik refleks mekanizmalar, progresif
hipoksi ve hiperkapni ileri siivilmtig ancak vagal aktivite artigmin
énernli olmadiéi, refleks mekanizmanin major bir rol oynamadigi gosterilmistir. Hiperbarik ortamda eritrosit SOD aktivitesinde azalma, lipid peroksidasyon tiriinlerinde artma ve gesitli membran fosfolipid
miktarlari ile bradikardik cevap arasinda korelasyon oldugu saptanmistir. Bu calismada SOD + katalaz ve allopurinol on uygulamasi hiperbarik bradikardi olugsumunu dniemistir. Bu bulgular hiperbarik
bradikardinin patogenezinde serbest oksijen radikallerinin rolu oldufunu ve serbest oksijen radikallerinin primer kaynagmim ksantin oksidaz aktivitesindeki artisa bagh olabilecegini géstermektedir.

Keywords

Allopiirinol , Antioksidanlar , Atmosferik basing , Bradikardi , Dalma , Hiperbarik oksijenasyon , Katalaz , Siiperoksit dismutaz , Ksantin oksidaz.

Ethical Statement

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Supporting Institution

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Project Number

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Thanks

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