Research Article

ANALYSIS OF FOUR-HOUR GROWTH HORMONE PROFILES AFTER ONSET OF SLEEP IN NORMAL AND GH-DEFICIENT CHILDREN: A STANDARDIZATION OF THIS SIMPLE TEST FOR CLINICAL USE

Volume: 54 Number: 3 September 30, 2001
Merih Berberoğlu *
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ANALYSIS OF FOUR-HOUR GROWTH HORMONE PROFILES AFTER ONSET OF SLEEP IN NORMAL AND GH-DEFICIENT CHILDREN: A STANDARDIZATION OF THIS SIMPLE TEST FOR CLINICAL USE

Abstract

The study comprised three groups of 131 prepubertal children. Group A included 55 healthy children and Group 8 included 66 children with GHD. Group C included 10 children with growth retardation but normal GH response to pharmacological tests with flat GH-sleep testing compared with those of Group A. All children except Group A underwent two pharmacological stimulation test for selection of patients. Spontaneous GH secretion was estimated by taking integrated 30 minutes blood samples for the first 4 - hour period of nocturnal sleep. The mean 4 - hour integrated GH concentration (ICGH), number of peaks (>5ng/ml) and the peak amplitude were calculated on 1048 occasions of sampling. The sensitivity of sleep test was defined by the percentage of true positive results. The mean ICGH, peak number and peak amplitude in the control group were 5.77+1.22, 3.98 + 1.37 and 15.91 + 2.2 ng/ml respectively. The mean ICGH was 2.14+0.26 ng/ml in Group B and 3.12+0.6 ng/ml for Group C. There was concordance between GH response to pharmacological stimulation and short time sleep testing in 58 of 66 GHD patients. Thus the sensitivity of the test is 87.7 %. in conclusion short time sleep test is safe, reliable and practical for clinical use. Four-hour sleep study should be especially indicated when GH responses to provocative testing are inconsistent with observed growth pattern. Long term sleep testing can be considered as a research tool rather than clinican one.

Keywords

Neorosecretuary Dysfunction; Short Time Sleep, test, uyku

References

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Details

Primary Language

English

Subjects

Pediatric Endocrinology

Journal Section

Research Article

Authors

Publication Date

September 30, 2001

Submission Date

February 19, 2001

Acceptance Date

June 19, 2001

Published in Issue

Year 2001 Volume: 54 Number: 3

IZ

https://izlik.org/JA37LR73TG

Cite

RIS / Bibtex
APA
Berberoğlu, M. (2001). ANALYSIS OF FOUR-HOUR GROWTH HORMONE PROFILES AFTER ONSET OF SLEEP IN NORMAL AND GH-DEFICIENT CHILDREN: A STANDARDIZATION OF THIS SIMPLE TEST FOR CLINICAL USE. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 54(3), 195-200. https://izlik.org/JA37LR73TG
AMA
1.Berberoğlu M. ANALYSIS OF FOUR-HOUR GROWTH HORMONE PROFILES AFTER ONSET OF SLEEP IN NORMAL AND GH-DEFICIENT CHILDREN: A STANDARDIZATION OF THIS SIMPLE TEST FOR CLINICAL USE. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2001;54(3):195-200. https://izlik.org/JA37LR73TG
Chicago
Berberoğlu, Merih. 2001. “ANALYSIS OF FOUR-HOUR GROWTH HORMONE PROFILES AFTER ONSET OF SLEEP IN NORMAL AND GH-DEFICIENT CHILDREN: A STANDARDIZATION OF THIS SIMPLE TEST FOR CLINICAL USE”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 54 (3): 195-200. https://izlik.org/JA37LR73TG.
EndNote
Berberoğlu M (September 1, 2001) ANALYSIS OF FOUR-HOUR GROWTH HORMONE PROFILES AFTER ONSET OF SLEEP IN NORMAL AND GH-DEFICIENT CHILDREN: A STANDARDIZATION OF THIS SIMPLE TEST FOR CLINICAL USE. Ankara Üniversitesi Tıp Fakültesi Mecmuası 54 3 195–200.
IEEE
[1]M. Berberoğlu, “ANALYSIS OF FOUR-HOUR GROWTH HORMONE PROFILES AFTER ONSET OF SLEEP IN NORMAL AND GH-DEFICIENT CHILDREN: A STANDARDIZATION OF THIS SIMPLE TEST FOR CLINICAL USE”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 54, no. 3, pp. 195–200, Sept. 2001, [Online]. Available: https://izlik.org/JA37LR73TG
ISNAD
Berberoğlu, Merih. “ANALYSIS OF FOUR-HOUR GROWTH HORMONE PROFILES AFTER ONSET OF SLEEP IN NORMAL AND GH-DEFICIENT CHILDREN: A STANDARDIZATION OF THIS SIMPLE TEST FOR CLINICAL USE”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 54/3 (September 1, 2001): 195-200. https://izlik.org/JA37LR73TG.
JAMA
1.Berberoğlu M. ANALYSIS OF FOUR-HOUR GROWTH HORMONE PROFILES AFTER ONSET OF SLEEP IN NORMAL AND GH-DEFICIENT CHILDREN: A STANDARDIZATION OF THIS SIMPLE TEST FOR CLINICAL USE. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2001;54:195–200.
MLA
Berberoğlu, Merih. “ANALYSIS OF FOUR-HOUR GROWTH HORMONE PROFILES AFTER ONSET OF SLEEP IN NORMAL AND GH-DEFICIENT CHILDREN: A STANDARDIZATION OF THIS SIMPLE TEST FOR CLINICAL USE”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 54, no. 3, Sept. 2001, pp. 195-00, https://izlik.org/JA37LR73TG.
Vancouver
1.Merih Berberoğlu. ANALYSIS OF FOUR-HOUR GROWTH HORMONE PROFILES AFTER ONSET OF SLEEP IN NORMAL AND GH-DEFICIENT CHILDREN: A STANDARDIZATION OF THIS SIMPLE TEST FOR CLINICAL USE. Ankara Üniversitesi Tıp Fakültesi Mecmuası [Internet]. 2001 Sep. 1;54(3):195-200. Available from: https://izlik.org/JA37LR73TG