Prostat Kanserli Hastalarda Bilateral Orkiektomi ve Flutamid Tedavisinin Karşılaştırılması

Year 1992, Volume: 45 Issue: 4 , 777 - 784 , 31.12.1992

Hamit Ersoy

https://izlik.org/JA92NJ86XM

Abstract

W, hormonal tedavi gerektiren 31 prostat kanseri hastasına bilateral orşiektomi uyguladı ve 15'ine steroid olmayan anti-androjen flutamid (750 mg/gün) tedavisi ekledi. Tek orşiektomi uygulanan grupta %-67 başarı oranı elde ederken; kombine tedavi alan grupta ilk yıl başarı oranı %92 oldu. Çiftçi grubunda %58 ve ikinci yılda ikinci grupta %8 oranında ilerleme görüldü. İki grup arasında istatistiksel olarak anlamlı bir fark olmasına rağmen, fhutamid eklendiğinde anti-androjen tedavisinin daha başarılı olduğunu gözlemledik. Prostat kanserinin heterojenliği ve anti-androjen tedaviye rağmen intraprostatik dihidrotestesteronun varlığı, başarı oranını zamanla azaltır ve nükslere neden olur:

Keywords

Brosiat kenseri , anti-androjen edna-Flutamid , bilateral orkiektomi

Ethical Statement

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‘Bilateral Orchiectomi Versus Bilateral Orchiectomi : And Flutamid “ , In Prostate Cancer Patients

https://izlik.org/JA92NJ86XM

Abstract

“W performed bilateral orchiectomi to the-31 prostate cancer. patiérits requiring hormonal therapy and added non-steroidal anti-androgen flutamid (750 mg/day) therapy to the 15 of them. While we got
the %:-67 success rate in the only orchiectomi: performed group; ‘the
success rate was % 92 in the combined therapy receiving group for
the first year. Progression was observed ‘in’ % 58 in the farmer’ group
and % 8 in the latter for the second year. Despite there was fio statistically meaningful difference between: two groups, we observed:-that:
the anti-androgen therapy was more suctessfull' by adding fhutamid.
The heterogeneity of the prostat cancer and the presente ‘of intraprostatic dihydrotestesterone despite anti-androgen therapy decrease
the success rate by the time being and cause relaps:

Keywords

Prostate cancer , anti-androjen therapy , Flutamid

Ethical Statement

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Thanks

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