Serum Laktik Dehidrogenaz izoenzim 1 (LDH-1)'in Germinal Testis Tümörlerinin Tanı ve İzlenmesindeki Rolü

Abstract

Bu galismada, primer testis tiimoérlii 29 olguda, orkiektomi 6ncesi ye sonrasi, kemoterapi ve radyoterapi sonras1 serum AFP, B-hCG ve LDH-1 izoenzimi duzeyleri incelenerek, 6zellikle LDH-1 izoenzimi uzerinde duruldu. Nonseminomatéz timdorlerin tanisinda, LDH-1 izoenziminin AFP ve BhCG ile birlikte yiksek degerlerinin énemli rol oynadigi gésterildi. Seminomatéz timérlerde ise, LDH-1 izoenziminin % 84,6 oraninda tanida degerli sonug verebilecek nitelikte oldugu saptandi. Ayrica, LDH-1 izoenziminin seminomatéz timorlerde tiimoriin evresi ile paralel olarak ylksek serum duzeylerine ulasabilecegi gésterildi.

Keywords

• Testis Tumori
• Laktik Dehidrogenaz
• izoenzim

THE ROLE OF SERUM LACTIC DEHYDROGENASE ISOENZYME 1 (LDH-1) IN THE DIAGNOSIS AND MONITORING OF GERMINAL TESTICULAR TUMORS

Abstract

In our study, we investigated pre-orchiectomy, post-orchiectomy, post-chemotherapy, post-radiotherapy serum AFP, B-hCG, and LDH-1 isoenzyme levels, in 29 cases with primary testis tumors, and we focused on LDH-1 isoenzyme, in particular. We showed that high levels of LDH-1 isoenzyme, along with AFP and B-hCG, play signinficant roles in the diagnosis of non-seminomatous tumors. And we pointed out the fact that LDH-1 isoenzyme is capable of yielding a correct outcome, with a 84,6 % possibility, in seminomatous tumors. We also observed that there is a correlation between tumor stages and serum LDH-1 isoenzyme levels.

Keywords

• Testis Tumori
• Laktik Dehidrogenaz
• izoenzim

References

1. 1. Boden G Gibb RB: Radiotherapy and Testicular Neoplasm. Lancet, 2 ; 1195, 1951.
2. 2, Dawson-Saunders B Trapp RB : Basic and Clinical Biostatictics. London, Sydney, Toronto, Mexico, New Delhi, Tokyo, Singapors, Rio de Jenerio, New Jersey prentice-Hall International. Inc., 149-151, 1990.
3. 3. Fossa A Fossa SD : Serum Lactate Dehydrogenase and Human Choriogonadotrophin in Seminoma. Br. J. Urol., 63 ; 408-415, 1989.
4. 4, Galen RS Gambino SZ : Beyond Normality. The Perdictive Value of Medical Diagnosis. New York, Jhon Wiley and Sons, 1975.
5. 5. Kinumaki H Takeuchi H Nakamura K et all : Serum Lactate Dehydrogenase isoenszyme-1 in Children With Yolksac Tumor, Cancer, 56 : 178-181, 1985.
6. 6. Koshida K Nishino A Yamamoto H et all : The Role of Alkaline Phosphatase isoenzymes As Tumor Markers For Testicular Germ Cell Tumors. J Urol., 146 : 57-60, 1991.
7. 7. Lange PH Winfield HN : Biological Markers in Urologic Cancer. Cancer, 60 : 464-472, 1987.
8. 8. Lippert MC Javadpour N : Lactic Dehydrogenase in The Monitoring and Prognosis of Testicular Cancer, Cancer, 48 : 2274-2278, 1981.

9. 9. Lippert M Papadopoules N Javadpour N : Role of Lactate Dehydrogenase Isoenzymes in Testicular Cancer. Urology. 18 : 50-53, 1981.
10. 10 Liu F Fritsche HA Trujillo JM Samuels ML : Serum Lactate Dehydrogenase Isoenzymel in Patients with Advanced Testicular Cancer. Am. J. Clin. Pathol., 78 ; 178-183, 1982.
11. 11 Scardino PT ; Adjuvant Chemotherapy is of Value Following Retroperitoneal Lymph Node Dissection for Nonseminomatous Testicular Tumors. Urol. Clin. North Am., 7 : 735, 1980.
12. 12 Tanisma K Hayashi MM Machikawa Y : Activity of Lactate Dehydrogenase Isoenzymes LD-1 and LD-2 in Serum As Determined by Using as Inhibitor of the M-Subunit, Clin. Chem., 31 : 1175-1177, 1985.
13. 13 Von Eyben FE Skude G Fossa SD Kleep O Borner O : Serum Lactate Dehydrogenase (S-LDH) and S-LDH Isoenzymes in Patients with Testicular Germ Cell Tumors. Mol. Gen. Genet., 189 : 326-333, 1983. .
14. 14 Von Eyben FE Blaabjerg O Petersen PH Horder M Nielsen HV Krause-Anderson 5 Parlev E : Serum Lactate Dehydrogenase Isoenzyme 1 As a Marker of Testicular Germ Cell Tumor. J. Urol., 140 ; 986-990, 1988