The Effect of Adjuvant Chemoradiotherapy Initiation Time on Prognosis in Glioblastoma Multiforme
Abstract
Objectives: To determine survival and investigate associated prognostic factors in glioblastoma multiforme (GBM) patients receiving adjuvant
therapy.
Materials and Methods: The study population comprised patients with isocitrate dehydrogenase wild-type GBM who were September 2022 and 1 March 2024. The primary endpoint was overall survival (OS), while the secondary endpoint was progression-free survival. Comparisons between groups were conducted using the log-rank test, and multivariate analyses were performed using Cox regression. Results: A total of 67 patients were evaluated. The median OS of patients was 19.3
months [95% confidence interval (CI) 15.1 to not reached (NR)]. A total of 60 patients (89.1%) underwent adjuvant treatment. The median OS was 31.1 months (95% CI 19.3 to NR) for patients treated within the first four weeks, 15.7 months (95% CI 15.1 to NR) for those treated within four to six weeks, and 11.3 months (95% CI 9.8 to NR) for those treated after six weeks.
Conclusion: The observed survival rate in our study was comparable to that reported in clinical trials. However, the survival rate was significantly lower in patients who received treatment at a later stage. Therefore, further studies with larger patient populations are recommended to ensure that the guidelines more accurately reflect the timing of adjuvant therapy in GBM patients.
Keywords
Glioblastoma multiforme, stupp protocol, overall survival, time to treatment
Ethical Statement
Ethics Committee Approval: This study was approved by the Scientific Research Evaluation and Ethics Committee of Etlik City Hospital (decision no.: AEŞH-BADEK-2024-758, date: 02.10.2024).
Informed Consent: Consent was not obtained since it was a retrospective study
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