Nefrotık Sendromlu Cocuklarda Tıroıd Fonksıyonları
Abstract
Thyroid function (TT:, TT;, FT:, FT;, TSH, TBG) were investigated in 27 patients with minimal change nephrotic syndrome during hypo- albuminemic phase before treatment. Serum TT3, TT:, FT; and FT; le- vels were marginally low. Those levels were compared to the normal controls and the difference was found statistically significant (P< 0,001). Although serum TSH levels were within the norma] range, tho- se were found higher than the control group (P< 0.05). Serum TBG levels were found within the normal limits of the same age (12-31 pg/ml.). No correlation was noted between serum total protein, serum al- bumin, urinary protein levels and thyroid function tests (P> 0.05).
Our patients did not have clinical hypothyroidism. But thyroid function tests were lower and serum TSH levels were higher than the control group of the same age. We suggested a subclinical hypothyro- idism might be complicated with the syndrome. A TRH stimulation test is necessary to prove this suggestion
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References
- 1. Adikofer F ve ark : Thyroid function in patients with proteinuria and normal or increased serum creatinine concentration. Acta Endocrinologica 102 : 367- 376, 1983, 2. Afrasiabi MA ve ark ; Thyroid function studies in the nephrotic syndrome. Ann Intern Med 90 : 335-338, 1979,
- 3. Brook : tific Clinical Paediatric Endocrinology 2nd ed. 1989. Plackwell Scien- GD Publications Oxford, London, Edinburgh, Boston Malbourne p. 703.
- 4. Burke CW Shakespear RA : Triiodcthyronine and thyroxine in urine. IJ. Renal handling, and effect of urinary protein. J Clin Endocrinol Metab 42 : 504-513, 1976.
- 5. De Luca F ve ark. ; Changes in thyroid function tests in infantile nephrotic syndrome. Horm Metabo] Res i5 : 258-259, 1983.
- 6. Evered B ve ark : Grades of hypothyroidism. Br Med J 1 : 657-662, 1973.
- 7. Ferrari C ve ark : Serum free thyroid hormones in different degrees of hypot- hyroidism and in euthyroid autoimmune thyroiditis, Acta Endocrinologica, 114 : 559-564, 1987.
- 8. Gavin LA ve ark : Alterations in serum thyroid hormones and thyroxine-binding globulin in patients with nephrosis, J Clin Endocrinol Metab 46 » 125-130, 1978.
- 9. Glass AR ve ark ; Low serum thyroxine and high serum triiodothyronine in nephrotic rats. Endocrinology 114 : 1745-1753, 1984.
- 10. Massry SG Glassock RJ : Textbook of Nephrology 2 nd ed. 1989 Williams and Wilkins Comp. Baltimore Hong Kong London Sydney p. 605-610.
- 11. Mc Enery RT Strife CF : Nephrotic syndrome in childhood. Ped. Clin North Am 89 875-894, 1982.