Nefrotık Sendromlu Cocuklarda Tıroıd Fonksıyonları

Abstract

Caligmada, minimal degisiklikli nefrotik sendrom tanis1 ile izle- nen 27 hastanın hipoalbuminemik evrede tiroid fonksiyonlari incelen- mistir. Hastalarimizda ayni yas grubu igin verilen referans değerlerinin alt sınırında bulunan TT:, TTs, sT; ve sT, degerleri kontrol grubu ile karşılaştırıldığında istatistiksel anlam gésterir sekilde diisiik dtizeylerde bulunmustur (P< 0.001). Bu bulguların yan sira TSH düzeyinin referans değerleri içinde olmakla beraber, kontrol grubuna gore ylksek oldugu dikkati cekmistir (P< 0.05). Nefrotik sendromlu hastalarimizda ortalama serum TBG diizeyinin yas icin belirtilen re- ferans degerler iginde (12-31 pe/ml)) oldufu gésterilmistir. Nefrotik sendromlu hastalarin serum total protein, serum albu- min duzeyleri ve idrardaki glinlik protein miktarlari ile tiroid fonk- siyon testleri (TT;, TT;, sT:, sT; TSH, TBG) arasinda istatistiksel iliski bulunmamıştır (P< 0.05). Hastalarımızda klinik hipotiroidi bulgular1 olmamasina karşın, tiroid hormon düzeylerinin kontrol grubuna değerlerine gére belir- gin dUstk, TSH’1n ise kontrol grubuna gére yiiksek degerlerde bulunmasi subklinik gizli hipotiroidinin varlignı duşündürtmektedir. Bu konunun kesin kanitlanmasi1 TRH testi ile olanak olacaktir. Elde ettigimiz veriler TRH testinin zorunluluğunu ortaya koymuştur.

Keywords

• nefrotik sendrom
• tiroid
• hipotiroidi

Nefrotık Sendromlu Cocuklarda Tıroıd Fonksıyonları

Abstract

Thyroid function (TT:, TT;, FT:, FT;, TSH, TBG) were investigated in 27 patients with minimal change nephrotic syndrome during hypo- albuminemic phase before treatment. Serum TT3, TT:, FT; and FT; le- vels were marginally low. Those levels were compared to the normal controls and the difference was found statistically significant (P< 0,001). Although serum TSH levels were within the norma] range, tho- se were found higher than the control group (P< 0.05). Serum TBG levels were found within the normal limits of the same age (12-31 pg/ml.). No correlation was noted between serum total protein, serum al- bumin, urinary protein levels and thyroid function tests (P> 0.05). Our patients did not have clinical hypothyroidism. But thyroid function tests were lower and serum TSH levels were higher than the control group of the same age. We suggested a subclinical hypothyro- idism might be complicated with the syndrome. A TRH stimulation test is necessary to prove this suggestion

Keywords

• Thyroid
• nephrotic syndrome
• hypothyroidism.

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