Correlation of Carotid Intima Media Thickness and Aortic Stiffness Index With Androgenetic Alopecia

Abstract

Androgenetic alopecia (AGA) is a common health problem that causes hair loss in both men and women due to the effect of androgens in the presence of genetic predisposition. Recent studies have shown that AGA patients are associated with an increased risk of coronary artery disease. Aortic stiffness index (ASI) and carotid intima-media thickness (CIMT) are considered strong markers for the presence of atherosclerosis. The aim of this study was to determine the possible relationship between ASI and CIMT in the presence of AGA.

Keywords

• Ateroskleroz
• Androgenetik Alopesi
• Artepiyel sertlik indeksi
• Aortik distensibilite
• Karotid intima media kalınlığı

Andogenetik Alopesililerde Karotid İntima Media Kalınlığı Ve Aortik Sertlik İndeksi İlișkisi

Abstract

Androgenetik alopezi (AGA), hem erkeklerde hem de kadınlarda genetic yatkınlık varlığında androgenlerin etkisiyle saç kaybı ile giden yaygın bir sağlık sorunudur. Yeni çalıșmalar AGA’lı hastalarda artmıș koroner arter hastalığı riski ile ilișkili olduğunu göstermiștir. Aortik sertlik indeksi (ASİ) ve karotid intima media kalınlığı (KİMK) ateroskeroz varlığı için güçlü belirteçler olarak kabul edilir. Bu çalıșmanın amacı, AGA varlığında ASİ ve KİMK arasındaki olası ilișkiyi belirlemektir.

Keywords

• Ateroskleroz
• Androgenetik Alopesi
• Artepiyel sertlik indeksi
• Aortik distensibilite
• Karotid intima media kalınlığı

References

1. 1- Sreekumar GP, Pardinas J, Wong CQ et al. Serum androgens and genetic linkage analysis in early onset androgenetic alopecia. J Invest Dermatol 1999;113:277279.
2. 2- Dunajska K, Milewicz A, Szymczak J et al. Evaluation of sex hormone levels and some metabolic factors in men with coronary atherosclerosis. Aging Male 2004;7:197–204.
3. 3- Hamilton JB. Male hormone stimulation is prerequisite and an incitantin common baldness. Am J Anat 1942:71:451480.
4. 4-. Norwood OT. Male pattern baldness: Classification and incidence. South Med J 1975;68:1359-1365.
5. 5- Dogramaci AC, Balci DD, Balci A, et al.Is androgenetic alopecia a risk for atherosclerosis?J Eur Acad Dermatol Venereol. 2009;23:673-677.
6. 6- Lang RM, Bierig M, Devereux RB, et al. Chamber Quantification Writing Group, American Society of Echocardiography’s Guidelines and Standards Committee, European Association of Echocardiography.Recommendations for chamber quantification: a report from the American Society of Echocardiography’s Guidelines and StandardsCommittee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am SocEchocardiogr 2005;18:14401463.
7. 7- Erdogan D, Calıskan M, Yıldırım I. Effect of normal blood pressure, prehypertension and hypertension on left ventricular diastolic function and aortic elastic properties. Blood Pressure 2007;16:114-121.
8. 8- Katakami N, Kaneto H, Shimomura I. Carotid ultrasonography: A potent tool for better clinical practice in diagnosis of atherosclerosis in diabetic patients. J Diabetes Investig. 2014;5:3-13.

9. 9- Nyholt DR, Gillespie NA, Heath AC, et al. Genetic basis of male pattern baldness. J Invest Dermatol 2003;121:15611564.
10. 10- Wynne FL, Khalil RA. Testosterone and coronary vascular tone: implications in coronary artery disease. J Endocrinol Invest 2003;26:181-186.
11. 11- Fujimoto R, Morimoto I, Morita E et al. Androgen receptors, 5 alphareductase activity and androgen-dependent proliferation of vascular smooth muscle cells. J Steroid Biochem Mol Biol 1994;50:169-174.
12. 12- Cotton SG, Nixon JM, Carpenter RG , et al. Factors discriminating men with coronary heart disease from healthy controls. Br Heart J. 1972;34:458–464.
13. 13- Lesko SM, Rosenberg L, Shapiro S. A case-control study of baldness in relation to myocardial infarction in men.JAMA 1993; 269:998-1003.
14. 14- Lotufo PA, Chae CU, Ajani UA et al. Male pattern baldness and coronary heart disease: the physicians’ health study. Arch Intern Med 2000;160:165171.
15. 15- Herrera CR, D’Agostino RB, Gerstman BB et al. Baldness and coronary heart disease rates in men from the Framingham Study. Am J Epidemiol 1995;142:828-833.
16. 16- Miric D, Fabijanic D, Giunio L et al. Dermatological indicators of coronary risk: a case-control study. Int J Cardiol 1998; 67:251-255
17. 17- Sharrett AR, Sorlie PD, Chambless LE, et al. Relative importance of various risk factors for asymptomatic carotid atherosclerosis versus coronary heart disease incidence: The Atherosclerosis Risk in Communities Study. Am J Epidemiol. 1999;149:843-852.
18. 18- van der Meer IM, Bots ML, Hofman A et al. Predictive value of noninvasive measures of atherosclerosis for incident myocardial infarction: the Rotterdam Study. Circulation 2004; 109:10891094.
19. 19- Arias-Santiago S, Gutiérrez-Salmerón MT, Castellote-Caballero L, et al. Androgenetic alopecia and cardiovascular risk factors in men and women: a comparative study. J Am Acad Dermatol. 2010;63:420-429.
20. 20- Agac MT, Bektas H, Korkmaz L, et al. Androgenetic alopecia is associated with increased arterial stiffness in asymptomatic young adults. J Eur Acad Dermatol Venereol. 2015;29:26-30.
21. 21- Sethi S, Rivera O, Oliveros R, et al.. Aortic stiffness: pathophysiology, clinical implications, and approach to treatment. Integr Blood Press Control. 2014;7:29-34.
22. 22- Roos CJ, Djaberi R, Schuijf JD, et al. Relationship between vascular stiffness and stress myocardial perfusion imaging in asymptomatic patients with diabetes. Eur J Nucl Med Mol Imaging. 2011;38:2050-2057.
23. 23- Safar ME, Levy BI. Studies on arterial stiffness and wave reflections in hypertension. Am J Hypertens. 2015;28:1-6.
24. 24- Cavalcante JL, Lima JA, Redheuil A, et al. Aortic stiffness: current understanding and future directions. J Am Coll Cardiol. 2011;57:1511-1522.