The Role Of Hormones İn Breast Cancer

Abstract

The role of endocrine factors in breast cancer development is not clear. In this study, we examined the comparative levels of E2, Progesterone, PRL, T3, T4, TSH, hGH and bèta-HCG as a tumor marker, in breast cancer patients and in a healthy control group. Higher serum PRL levels were discovered in postmenopausal patients when compa red to the control group (p< 0.05). Likewise, in premenopausal patients, Progesterone levels at follicular phase and T4 and hGH levels were significantly different than the control group 0.05). HoweVer, E2 levels at pre and postmenopausal patients, P levels in postmenopausal patients, T3, TSH and Beta-HCG levels were similar to those of the control group. Furthermore, the PHL and Beta-HCG levels failed to show a correlation with the disease activity

Keywords

• cancer
• breast
• hormone
• endocrine

Meme Kanserinde Hormonların Rolü

Abstract

Meme kanserinin gelişmesinde endokrin faktörlerin rolü tartışmalıdır. Bu çalışmada meme kanserli hasta ve sağlıklı kontrol grubunda karşılaştırmalı olarak E2, Progesteron,, PRL,T3,T4,TSH,hGH ve tümör belirleyici olarak beta-HCG düzeyleri incelenmiştir. Meme kanserinin gelişmesinde endokrin faktörlerin rolü tartış malıdır. Bu çalışmada meme kanserli hasta ve sağlıklı kontrol gruplarmda karşılaştırmalı olarak E), Progesieron, PRL, T3, T4, TSH, hGH ve tümör belirleyici olarak beta-HCG düzeyleri incelenmiştir.Sonuç olarak; postmenapozal grupta PRL, premenapozal folliküler fazda progesteron ile T4 ve hGH düzeylerinin hasta ve kontrol gruplarındaki tartışmalarında anlamlı farklılıklar ( p<0.05) saptanırken,premenapozal grupta PRL, pre ve postmenapozal E2, postmenapozal progesteron ile T3, TSH ve beta-HCG düzeylerinin karşılaştırılmasında anlamlı farklılıklar saptanmamıştır.( p > 0.05). Ayrıca hasta grubunda PRL ve beta-HCG düzeylerinde hastalığın aktivitesine göre anlamlı farklılık saptanmadı ( p > 0.05). ..

Keywords

• kanser
• meme
• hormon
• endokrin

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