Antifosfolipid Antikorları

Nurşen Düzgün

TR EN

Antifosfolipid Antikorları

Abstract

Antifosfolipit antikor ailesinden başlıca iki grubu iyi belirlenmiştir. Bunlar lupus antikoagülanı ve antikardiyolipin antikorudur. Antikordiyolipin antikorunun varlığını, biyolojik false pozitif standart sıfiliz testi yansıtabilirse de, daha hassas bir yöntem olan standardize edilmiş ELİSA ile tayin etmek mümkündür. Sistemik lupus eritematozus ve romatoid artrit gibi otoimmün hastalıklarda, yüksek antikardiyolipin antikor seviyeleri saptanmıştır. Otoimmün olmayan hastalıklarda da antikordiyolipin antikor pozitifliği gösterilmiştir. Çalışmaların çoğunda, yüksek antikardiyolipin antikor ve onunla yakın ilişkili olan lupus antikoagülanın trombozis. rekürrent fetus kaybı ve trombositopeni ile beraberlik gösterdiği dikkati çekmiştir. Fosfolipitlere karşı oluşan bu antikorların trombozisde patogenetik bir rolü olup olmadığı konusu kesin bilinmemektedir. Yüksek antikardiyolipin antikorları saptanan hastalarda immunosüpresif tedavinin önemi ve yeri tartışmalıdır.

Keywords

antikor, antikoagülan, Antikordiyolipin

References

1. Asherson, RA. Lanham, JG,., Hull, RG,, Boey, ML., Gharavi, AE and Hughes GRV. : Renal vein thrombosis in systemic lupus erythematosus. Clin. Exp. Rheumatology 2 : 75-79, 1984.
2. Ashersan, RA., Mackworth - Young CG,, Boey, ML. : Pulmonary hypertension in systemic lupus erythematosus. Br. Med. J. 287 : 1024-1025, 1983.
3. Boxer, M. Ellman, L., Carvalho-A. : The lupus anticoagulant. Arth. Rheum. 19; 1244-1248, 1976.
4.Bowie, EJW., Thomson, JH., Pascussi, CA., Owen, CA. : Thrombosis in systemic lupus erythematosus despite circulating anticoagulant, J. Lab, Clin. Med. 62:416-430, 1963.
5.Carrras, LO., Defreyn, G., Machin, SJ., Vermylen, J., Deman, R., Spitz, B., Assche, AV. : Arteriel thrombosis, intrauterine death and lupus anticoagulant : detection of immunglobulin interfering with prostocylin formation. Langet 2 : 366, 1880.
6.Colaco, CB, Male, DK. : Antiphospholipid antibodies in syphilis and a thrombotic subset of systemic lupus eryihematosus : distinci profiles of epitopespecificity. Clin. Exp. Immunol, 59 : 449-456, 1985.
7.Conley, CI, Hartmann, RD.:A hemorajic disorder caused by circulating anticoagulant in patients with systemic lupus eryihematosus, J, Clin. Invest. 31 ; 621-022, 1952.
8.Düzgün, N., Dağalp, Z. : Anticerdiolipin antibodies in patients with systemic lupus eryihemafosus and rheumatoid arthritis. 4th Mediterranean congress of “ rheumatology, 2-3 June 1988 Istanbul. Abstract book pages : 49.
9.Efthimiou, J., Harris, EN, Hughes, GRV.: Negative anticardiolipin antibodies and vaşscular complications in Behçet's syndrome. Arın, Rheum. Dis. 44 : 725-726, 1985 10.Fırkın, BG., Howard, MA., Radford, N, : Possible relationship between lupus inhibitor and recurrent abortion in young women. Lancet 2 : 366, 1980.
11.Fort, JG., Cowehock, Fs., Abrusso, JL,, Smith, JB. : Anticardiolipin antibodies in patients with rheumatic diseases. Art. Rheum, 30 : 752-780, 1987.

12.Fulford, KWM., Catterall, RD., Delhaniy, JJ. ; A collagen disorder of the nervous system presenting as multiple sclerosis, Brain 95 : 187-190, 1986.
13.Hamsten, A., Norberg, R., Björkholm, Defaire, U., Holm, G. : Antibodies to cardiolipin in young survivors of myocardial infarction : A associaiton with recurrent cardiovascular events. Lancet 1 113, 1986.
14.Harris, EN., Gharavi, AE., Asherson ,RA., Boey, ML, Hughes, G. : Cerebral infarction in systemic lupus erythematosus : association With anticardiolipin antibodies. Clin. Exp. Rheumatol. 2 : 47-51, 1984.
15.Harris, EN. Gharavi, AE. : Antiphospholipid antibodies. Clin. Rheum, Dis, ( :591 - 606, 1985.
16.Harris, EN,, Gharavi, AE., Boey, ML,, Patel, BM, Mackworth-Young, Gn. Loizon. s., Hughes, GRV. : Anticardiolipin antibodies : Detection by radioimmunoassay and association with thrombosis in systemic lupus eryihematosus Lancet 3: 1211-1214; 1983. 5
17.Harris, EN., Gharavi, AE;, Hegde, U., Derve, G., Morgan, SH., Englert, H., Chan, JHK., Asherson, RA., Hughes-GRV. :-Anticardiolipin antibodies in autoimmune ihrombocytopenic punpura. Br. J. Haemaiol. 59 : 231, 1985.
18.Harris, EN., Hughes; GRV. : Standardizing the anticardiolipin antibody- test. Laricet 277, 1987.
19.Harris, EN., Hughes, GRV., Gharavi, AE. : Anticerdiolipin antibodies and lupus anticoagulant. Clin, Exp. Rheum, 4 : 187-190, 1986.
20.Harvey, AM, : Autoimmune disease and the chronic biologic false positive tesi for syphilis. J. Am. Med. Assoc. 182 : 513, 1962.
21.Hughes, GRV. : Autoantibodies ın lupus and its variants : Experience in 1000 . Patienis. Br. Med. J, 289 ; 339-342, 1984.
22.Hughes, GRV., Harris, EN. Gharavi, AE. : The anticardiolipin syndrome. J. Rheumi, 13 : 486, 1988.
23.Hughes, GRV., Harris, EN., Gharavi, AE, : Antiphospholipid antbiodies. Edited “by Gupta, -S., Talal, N: in Immunology of Rheumatic Disease 251-269 1985.
24. Hull, RG, Harris, EN., Gharavi, AE. Tincani, A., Asherson, RA,, Valesu, G, Denman, AM,, Froude, G., Hughes, GRV, : Anticardiolipin antibodies occurence in Behçet's Syndrome. Ann. Rheum. Dis. 43 : 746, 1984.
25.Koike, T., Sueshi, M., Funakı, H., Tomioka, H., Yoshida, 5. ; Antiphospholipid an tibodies and Biologic false positive serological test for syphilis and a thrombotic subset of systemic lupus erythematosus. Clin. Exp. Immunol. 56 : 193, 1984.
26.Koike, T., Tomiaka,H. , Kemagal, A. ; Antibodies cross reactive with DNA and cardiolipin in patients with systemic lupus erythematosus, Clin. Exp. Immunol. 50 : 298, 1982
27.Lenzi, R., Rand, JH., Spiera, H. : Anticardiolipin anticardiolipin antibodies in pregnant patients with systemic lupus eryihematosus, N, Eng. J. Med. 314 : 1382, 1986.
28.Lockshine, M. : Anticardiolipin antibodies. Arh. Rheum. 30 : 471-472, 1987.
29.Lockshine, M., Druzin, ML., Goel, 5., Guinor, T., Magid, MS, Jovanic, L., Ferenc, M. : Antibody to cardiolipin as a predictor of fetal distress or death in pregnant patients with systemic lupus erythematosus. N. Eng. J. Med. 313 : 152, 1985,
30.Loizou, SJD., Mecrea, AC. Rudge, AC, Reynolds, R., Cathrine, C., Boyle, CC, Harris, EN. : Measurement of anticardiolipin antibodies by an enzyme linked immunosorbent assay (ELISA) ; Standardization and guantitation of resulis. Cün, Exp. Immunol, 62 : 738-745, 1985.
31.Marcus, DM and Schwartig, GA. : Immunochemical properties of giycolipids and phospholipids. Adv. lmmunol, 23 : 203, 1976,
32.Moore, JE., Mohr, CF, : Biologically false positive serologic test for syphilis type, incidence and cause. JAMA. 150, 467, 1952.
33.Much, JR., Herbst, KD., Rapaport, 5I. : Thrombosis and patients with lupus anticoagulant. Ann. Int. Med. 92 ; 156-159, 1980.
34.Norberg, R., Nived, O,, Sturlelt, G., Unander, M., Arfors, LI : Anticardiolipin antibodies and complement activation : relation to clinical symptoms. J. Rheumatol,14 ; 149, 1987.
35.Pangborn, MC. ; A new serologically active phospholipid from beef heart Proc. Soc. Exp. Biol. Med. 48 : 464-486, 1941 (literatür 31'in referensi).
36.Rauch, J., Tannenbaum, H., Stollar, D., Sçhwartz, RS. : Monoclonal anticardiolipin antibodies bind to DNA. Eur, J. Immunol. 14 : 529-534, 1984,
37.Schleider, MA., Nachman, RI. Jaffe, EA., Coleman, M. : A clinical study of the lupus anticoagulant, Blood 48 : 499-509, 1976.
38.Seibold, JR. : Anticardiolipin antibodies in systemic sclerosis. Arth. Rheum. 29 : 1052, 1986.
39.Sturfelt, G., Nived, O., Norberg, R., Thorstensson, R., Krook, K. ; Anticardiolipin antibodies in patients with systemic lupus erythematosus, Arth. Rheum. 30 (4) ; 382-388, 1987.
40.Sukenik, 5., El Roeiy, A., Shoenfeld, Y. : Lupus anticoagulânt and anticardiolipin antibodies in systemic lupus erythematosus, Acta, Haemat, 76 : 88, 1988.
41.Thiagarajan, P., Shapiro, 55., De Marco, L. ; Monoclonal immunglobulin M lambda coagulation inhibitor with phospholipid specificity. Mechanism of a lupus anticoagulant, J. Clin. Invest, 66 : 397-405, 1980,
42.Tokgöz, G., Düzgün. N., Gürler, A., Gül, Ü,, Tutkak, H. : Anticardiolipin antibodies in Behçet's Disease. ist Mediterranean of Behçet's Symposium on Behçet's
43.Disease. 4june 1988 Istanbul, Abstract book page : Vaarala, D., Polosuo, T., Klemola, M., Anticardiolipin response in acute enfections, Clin. Immunol, Immunopathol, 41 : 8-15, 1986.
44.Wasserman, A., Neisser, A., Bruck, C. : A serodiagnostic reaction for syphilis Deutsch. Med. W. Sahur. 320745, 1906. (literatür 17'nin referensi),

Details

Primary Language

Turkish

Subjects

Immunology (Other)

Journal Section

Research Article

Authors

Nurşen Düzgün ^*
Türkiye

Publication Date

March 31, 1990

Submission Date

January 1, 1990

Acceptance Date

March 31, 1990

Published in Issue

Year 1990 Volume: 43 Number: 1

IZ

https://izlik.org/JA53YF34RN

APA

Düzgün, N. (1990). Antifosfolipid Antikorları. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 43(1), 237-246. https://izlik.org/JA53YF34RN

AMA

1.Düzgün N. Antifosfolipid Antikorları. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1990;43(1):237-246. https://izlik.org/JA53YF34RN

Chicago

Düzgün, Nurşen. 1990. “Antifosfolipid Antikorları”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 43 (1): 237-46. https://izlik.org/JA53YF34RN.

EndNote

Düzgün N (March 1, 1990) Antifosfolipid Antikorları. Ankara Üniversitesi Tıp Fakültesi Mecmuası 43 1 237–246.

IEEE

[1]N. Düzgün, “Antifosfolipid Antikorları”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 43, no. 1, pp. 237–246, Mar. 1990, [Online]. Available: https://izlik.org/JA53YF34RN

ISNAD

Düzgün, Nurşen. “Antifosfolipid Antikorları”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 43/1 (March 1, 1990): 237-246. https://izlik.org/JA53YF34RN.

JAMA

1.Düzgün N. Antifosfolipid Antikorları. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1990;43:237–246.

MLA

Düzgün, Nurşen. “Antifosfolipid Antikorları”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 43, no. 1, Mar. 1990, pp. 237-46, https://izlik.org/JA53YF34RN.

Vancouver

1.Nurşen Düzgün. Antifosfolipid Antikorları. Ankara Üniversitesi Tıp Fakültesi Mecmuası [Internet]. 1990 Mar. 1;43(1):237-46. Available from: https://izlik.org/JA53YF34RN

Antifosfolipid Antikorları

Antifosfolipid Antikorları

Abstract

Keywords

Antiphosholipid Antibodies

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

IZ

Cite