Serum immunoglabuline A,M and G levels at pre enel post theropy in head and neck Concers.

Abstract

The pre and post therapy serum immunglobuline A. M. and G. levels of 32 head and neck Cancer patients are inivestigated. The radiotherapy results of pre and post therapy and operative values are compared. Also the gamaglobulin levels are studied whether they are inflicted by neck metastasis or not. The Ig A levels statistically found hgih in our patients, however the decrease after the therapy in meaningfull. The effects of radiotherapy and the operation on Ig A are the same. The metastase to the neck does not effect the gamaglobuline levels. Statistically the differences between Ig A and Ig G levels are not important.

Keywords

• immunglobuline A
• metastase
• radiotherapy

BAS - BOYUN KANSERLi HASTALARDA TEDAVI ONCESi VE SONRASI SERUM IMMUNOGLOBULIN -A- M, ve G DEGERLERI

Abstract

Baş ve boyun kanseri olan 32 hastanın serum IgA, M ve G değerlerinin tedavi öncesi ve sonrasındaki seviyeleri araştırıldı. Tedavi öncesi ve sonrası ,radyoterapi ve operasyon sonrası degerler karşılaştırıldı. Ayrıca boyuna metastazların immünoglobülinlerin seviyelerini etkileyip etkilemediği incelendi. Hastalarımızda tedavi öncesi IgA istatistiki olarak yüksek bulunmus olup, tedavi sonrası düşüşde aynı şekilde anlamlıdır. Radyoterapi ve operasyoniun IgA üzerindeki etkileri aynı derecededir. Boyuna metastaz immünoglobülin düzeylerini etkilememektedir. IgM ve IgG seviyelerindeki farklılık istatistiki olarak önemli değildir.

Keywords

• Baş ve boyun kanseri
• radyoterapi
• IgA

References

1. 1. Ablin R., Gonder M.J., Soenes W.A. : Levels of immunoglobulin in the serum of patients with carcinoma of the prostate. Neoplasma. 19 : 57-60, 1972.
2. 2. Anderson. P., Pederson, O.E., Bach B, Bonde G.J. : Serum antibodies and immiinoglobulins in smokers and nonsmokers, Clin. Exp. Immunol. 47 : 467-473, 1982.
3. 3. Brown AM, Lally ET., Frankel, A, Harwick R. Davis LW., Rominger C.J. » The association of the IgA levels of serum and whole saliva with the progression of oral cancer, 35 : 1154-1162, 1975.
4. 4. Clifford P. : The principles of cancer immunology with particular reference to head and neck. In Scott-Brow’s Diseases of the Ear, Nose and Throat. 4. th. editions. Vol : 1, Butterworths. 1978.
5. 5. Dostalova O., Wagnenova V., Schén E., Wagner, V., Jelinek J. : Serum immunoglobulin levels in cancer patients III. Immunoglobulin levels and metastases of malign tumors. Neoplasma. 24 : 177-191, 1077.
6. 6. Gillmezoglu E. : Bağışklığın temelleri. Hacettepe Universitesi Yayınları. A/16, 1983.
7. Hughes N.R. : Serum concentrations of G,A and M immunoglobulins in patients with carcinoma, melanoma and sarcoma. J. Natl. Cancor. Inst. 46 : 1015- 1028, 1971.
8. Katz E.A., Yoo T.J., Harker L.A. : Serum Immunoglobulin A (IgA) levels in carcinoma of head and neck. Trans. Am. Acad. Ofthalmol. Otolaryngol. 82 : 131- 137, 1976.

9. Katz A.E., Nysather J.O. Harker L.A. : Major immunoglobulin rations in carcinoma of the head and neck. Ann. Otol., 87 ; 412-415, 1978.
10. Katz A.E. : Inmunobiologic staging of patients with carcinoma of the head and neck. Laryngoscope. 93 : 445, 1083.
11. Khanna N.N,, Das S.N., Khanna'S. : Serum immunoglobulins squamous cell carcinoma of the oral cavity. J. Surg. Oncol. 20 : 46-48, 1982.
12. Lin TM, Yang C.S., Chiou J.F., Tu SM, Lin CC, Liu CH, Chen K.P., Ito Y., Kawamura, A., Hirayama T. : Seroepidemiological studies on carcinoma of the nasofarynx. Cancer Reserch. 33 : 2603-2618, 1973.
13. Mancini G., Carbonara A.O., Heremans x.F. : Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistr. 2 : 235, 1965.
14. Neel H B. III, Ritts R.E. : Tumor-specific immunity and the otolaryngologist. Ann. Otol. 82 : 323-329, 1973.
15. Nicsic M., Balogh M. : Die Serum immunoglobulinsbei Patienten mit Malignomen des Kehkopfs und des Rachens. Laryng. Rhinol. 55 : 882-887, 1976. Pottingale K.W., Merret T.G., Tee D.E. : Prognostic value of serum levels of immunoglobulins (IgA, IgG, IgM ve IgE) in breast cancer. Apreliminary study, Br. J. Cancer. 36 : 550, 1977.
16. Plesnicar S. : Immunoglobulins in carcinoma of the uterine cervix. Acta Radiol. 11 : 37-47, 1972.
17. Roitt LM. : Essential Immunology., 3nd edition. Blackwell Sci. Pub. 1977.
18. Ronald B., Herberman M.D. Cancer. 37 : 549-562, 1976.
19. Immunologic approches to diagnosis of cancer. Sako K., Minowada J., Marchetta F.C. : Epstein-barr virus antibodies in patients with carcinoma of the nasopharynx and carcinoma of other sites in the head and neck. Am. J. Surg., 130 : 437-439, 1975.
20. Silverman N.A., Alexander J.C., Chretien P.B. : CEA levels in head and neck cancer. Cancer. 37 : 2204, 1976.
21. ‘Wara W.M., Ammann A.J., Wara D.W,, Phillips T.L. : Serum IgA in diagnosis of the nasopharyngeal and paranasal sinus carcinoma .Radiology. 116 : 409 411, 1975,
22. Wara W.M., Wara D.W,, Phillips T.L., Ammann A.J. : Eleveted IgA in carcinoma of the nasopharynx. Cancer 35 : 1313-1315, 1975.
23. ‘Watanabe T, Iglehart J.D., Bolognesi D.P. : Secretory immune response in patients with orofaryngeal carcinoma. Ann. Otol. Rhinol. Laryngol. 92 : 295, 1983.