Kronik Konjestif Kalp Yetmezliğinde İsosorbid Dinitrat'ın Sol Ventrikül Fonksiyonuna Etkisinin Klinik Ve Ekokardiyografik Olarak İncelenmesi

Year 1982, Volume: 35 Issue: 3, 519 - 524, 30.09.1982

Sinan Akpınar

Abstract

1 — Çalışma, 1981 yılında A.Ü. Tıp Fakültesi Kardiyoloji kliniğinde yatan, «digital * diüretik» tedaviye refrakter 11 kronik konjestif kalb yetmezlikli hasta üzerinde yapılmıştır.

Keywords

Tedaviye dirençli kalp yetmezliği , İzosorbid dinitrat , Sol ventrikül fonksiyonel kapasitesi

The effect of isosorbid dinitrat on left ventircular function in chronic congestive heart failure. A study made by clinical and echocardiographic examination

Abstract

In this paper we studied 11 cases of intractable heart failure refractory to all treatment. Although they have been taking full dosisol digilalis and diuretic, displeyed no regression in any symptom and sign of the congestive heart failure, In an attempt to ameliorate the clinical status we prescribed to all patient per os isosorbid dinitrate 160 mg daliy devieded in egual dosis during 7 days. By this method left ventricular functional capacity, studied by echocardiography and clinical syptoms and signs of the conestive heart failure improved substantialIy.

Keywords

Intractable heart failure , Isosorbide dinitrate , Left ventricular functional capacity

Ethical Statement

-

Supporting Institution

-

Thanks

-

References

• 1, Allan D. Sniderman, Derek GF. Marpole, Wilfred H. Palmer, and Ernest L. Fallen : Response of the left veniricle to niiroglycerin in patients with and without mitral regurgitation. Brit. H. Journal, 36 : 357-361, 1974.
• 2. Anthony N. Maria, Louis A, Vismara, Karen Auditore, Ezra A. Amsterdam, Robert Zeus, Dean Mason : Effects of nitroglycerin on left ventricular cavitary size and cardiac performance determined by ultrasound in man, Am, Journal Med. 57 : 754-760, 1974,
• 3, Barr, H. Greenberg, Barry M. Massie, Bruce H. Brundage, Elias H. Botvinick, William W. Parmley and Kanu Chatterjee : Beneficial effects of Hydralazine in severe mitral regurgitation. Circulation, 58 : 273-279, 1978.
• 4. Barıy M., Kanu C,, Jefirey W., William W. : Hemodynamiç advantage of combined administration of Hydralazine oraliy and nitrates nonparenteraliy in the vasodilator therapy of chronic heart failure. Am. 1. of Cardiol. 40 : 794-801, 1977.
• 5. Benchimal A. : Non-invazive diagnostic technigues in cardiology. The Williams and Wilkins Company Baltimore. 15-29, 1977,
• 6. Chaim Y. Edward ve ark, : Mechanism of teduction of mitral regurgitation with Vasodilator therapy. The Am. 1. of Cardiol, 43 : 774-777, 19179.
• 7. Charles WH. William G., Alal B.M., and Tambert P, : Reduced systemic vascular Te sistance as therapy for severe mitral regurgitation of valvular origin, Ann, of İnter. Med. 83 : 312-316, 1975.
• 8. Chatterjee and William W. Parmley : Progress in cardio-vaşcular diseases. Vol, KIZ, Na, 4 (January, February), 301-325, 1977.
• 9. Clark RD : Ekokardiyografide Olgu İncelemeleri. Tanı alıştırma kitabı, 1977.
• 10. Daniel T. Danahy ve ark. : Sustained hemadynamic and antianginal effect of high dose oral isoserbid dinitrate. Circulation. 55 : 381-387, 1977.
• 11. David OW., Ezha AA, and Dean TM. : Hemodynamic effect of nitrogiycerin in acuis myocardial infaretion. Circulation, 51 : 421-427, 1975.
• 12. David OW., William JB., Richard RM., Ezra AA., Dean TM. > Hemodynamic assessment of oral peripherel vasodilator therapy in chronic congestive heart İailure : Prolonged effectivess of isosorbide dinitrate, Am. J, of Cardiol. 39 : 84-89, 1977,
• 13. Dean T. Mason : Vasodilator an inotropic therapy of heart failure, Am. J. of Medicine, 65 : 101-105, 1978.
• 14. Estaben M., Joseph AF, and Jay NC. : Comparative hemodynamic effects of chewable isasorhide dinitrate and nitroglycerine in patienis with congöstive heart failure, Circulation, 52 : 477-482, 1975.
• 15. Feigenbaum H. : Ekokardiografi (Pektaş, O.) 1976.
• 16. Herman KG., Robert CL., and Charles AS. : Use of sublingual nitrogiycerin in congesüye failure fallowing acutz myocardial infaretion, Circulation. 46 : 839-845, 1972,
• 17. Hrateh K.. Leslie W., Pete RD., Ronald SG., Albert NB. : Comparative hemodynamic effect of placebo and oral isosorbid dinitrate in patients With significant coronary arter) disease. Am. H. ournal, 90 : 68-74, 1975.
• 18. Jâime F., William RT., Takeshio 0., James SF., Braham N,, and H.C. Swan : Com parative haemodynamic and peripheral vasodilator effects of oral and chewable isosorbid dinitrate in patients with refractory congestive cardiac failure Brit. Heart. Journal, 41 : 317-324, 1979.