Frequency of Vitamin D Deficiency in Postmenopausal Women Who Live in Ankara Region

Abstract

Objectives: The aim of this study is to define the frequency of vitamin D deficiency in postmenopausal women and to evaluate its implications on bone metabolism. Patients, who admitted to the Ankara University Faculty of Medicine Outpatient Clinics included to the study. Materials and Methods: The study was conducted as a cross-sectional study. Postmenopausal women were scanned with DEXA and divided into three groups as osteoporosis, osteopenia, and the control group according to the T scores. During medical visit, patients’ clothing habits, and daily sunlight exposure rates have been scored from 1 to 4 with a questionnaire. Vitamin D, Parathyroid hormone (PTH), osteocalcin, Dependent personality disorder (DPD), calcium, phosphorus, Alkaline phosphotase (ALP) levels were compared. Results: 29.8% of the women had osteoporosis, and 45.8% had osteopenia. Forty eight women (36.6%) were reported to have severe vitamin D deficiency (25-OH-D<10 ng/mL), 38 women (%29) moderate vitamin D deficiency (10≤25-OH-D<20 ng/mL), and 22 women (%16.8) mild vitamin D deficiency (20≤25-OH-D<30 ng/mL). Only 23 of the women (17.6%) had vitamin D levels higher than 30 ng/mL. It was observed that as the vitamin D levels dropped, PTH levels increased. The threshold for 25-OH-D level was estimated as 16.3 ng/mL. A negative relation was observed between vitamin D and osteocalcin and a positive relation was observed between ALP, osteocalcin and PTH. Conclusion: Since the research to find out preventive effects of vitamin D on chronic diseases such as cancer, hypertension, diabetes mellitus and it is already known that vitamin D reduces the risk of falls and fracture, closer follow-up of patients with vitamin D levels below 16.3 ng/mL with appropriate vitamin replacement may be important in reducing bone loss.

Keywords

• Postmenopausal Osteoporosis
• Secondary Hyperparathyroidism
• Vitamin D Deficiency

Ankara Bölgesinde Yaşayan Postmenapozal Kadınlarda D Vitamini Eksikliği Görülme Oranı

Abstract

Amaç: Ankara Üniversitesi Tıp Fakültesi Dahiliye Polikliniklerine başvuran postmenapozal kadınlarda D vitamini eksikliği sıklığının ve kemik metabolizması üzerine olan etkilerinin belirlenmesi. Gereç ve Yöntem: Çalışma kesitsel bir çalışma olarak düzenlendi. Postmenapozal 131 kadın Dexa ile taranarak osteoporoz, osteopeni ve kontrol grubu olarak üçe ayrıldı. Hasta viziti sırasında hastaların giyimleri ve günlük aldıkları güneş ışığı miktarı 1’den 4’e kadar skorlandı. Bu kadınlarda D vitamini, Paratiroid hormon (PTH), osteokalsin, Bağımlı kişilik bozukluğu (DPD), kalsiyum, fosfor, Alkalin fosfataz (ALP) seviyeleri karşılaştırıldı. Bulgular: Kadınların %29,8’inde osteoporoz, %45,8’inde osteopeni saptandı. Kırk sekiz kadında (%36,6) ağır D vitamini eksikliği (25-OH-D<10ng/ mL), 38 kadında (%29) orta dereceli D vitamini eksikliği (10≤25-OH-D<20 ng/mL arası), 22 kadında (%16,8) hafif D vitamini eksikliği (20≤25- OH-D<30 ng/mL arası) saptandı. Kadınların sadece 23’ünde (%17,6) D vitamini 30 ng/mL’nin üzerinde bulundu. D vitamini seviyesi azaldıkça PTH seviyesinde artış olduğu gösterildi. D vitamini eksikliği için eşik değer 16,3 ng/mL saptandı. Kemik belirteçleri değerlendirildiğinde D vitamini ilişkisi incelendiğinde D vitamini ile osteokalsin arasında negatif ilişki, ALP ve osteokalsin ile PTH arasında pozitif ilişki gösterildi. Sonuç: Dünya genelinde D vitamini eksikliğine sık rastlanmaktadır ve D vitaminin kanser, hipertansiyon, diabetes mellitus gibi kronik hastalıklardan koruyuculuğu, düşme ve kırık riskini azalttığı bilinmektedir. D vitamini seviyesi 16,3 ng/mL’nin altında olan vakaların uygun vitamin replasmanı ile daha yakın takibi kemik kaybını azaltmada önem arz etmektedir.

Keywords

• D Vitamini Eksikliği
• Postmenapozal Osteoporoz
• Sekonder Hiperparatiroidizm

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