The Role Of Hormones İn Breast Cancer

Year 1990, Volume: 43 Issue: 2, 327 - 342, 30.06.1990

Fikri İçli

Abstract

The role of endocrine factors in breast cancer development is not clear. In this study, we examined the comparative levels of E2, Progesterone, PRL, T3, T4, TSH, hGH and bèta-HCG as a tumor marker, in breast cancer patients and in a healthy control group. Higher serum PRL levels were discovered in postmenopausal patients when compa red to the control group (p< 0.05). Likewise, in premenopausal patients, Progesterone levels at follicular phase and T4 and hGH levels were significantly different than the control group 0.05). HoweVer, E2 levels at pre and postmenopausal patients, P levels in postmenopausal patients, T3, TSH and Beta-HCG levels were similar to those of the control group. Furthermore, the PHL and Beta-HCG levels failed to show a correlation with the disease activity

Keywords

cancer , breast , hormone , endocrine

Ethical Statement

-

Supporting Institution

-

Project Number

-

Thanks

-

Meme Kanserinde Hormonların Rolü

Abstract

Meme kanserinin gelişmesinde endokrin faktörlerin rolü tartışmalıdır. Bu çalışmada meme kanserli hasta ve sağlıklı kontrol grubunda karşılaştırmalı olarak E2, Progesteron,, PRL,T3,T4,TSH,hGH ve tümör belirleyici olarak beta-HCG düzeyleri incelenmiştir. Meme kanserinin gelişmesinde endokrin faktörlerin rolü tartış malıdır. Bu çalışmada meme kanserli hasta ve sağlıklı kontrol gruplarmda karşılaştırmalı olarak E), Progesieron, PRL, T3, T4, TSH, hGH ve tümör belirleyici olarak beta-HCG düzeyleri incelenmiştir.Sonuç olarak; postmenapozal grupta PRL, premenapozal folliküler fazda progesteron ile T4 ve hGH düzeylerinin hasta ve kontrol gruplarındaki tartışmalarında anlamlı farklılıklar ( p<0.05) saptanırken,premenapozal grupta PRL, pre ve postmenapozal E2, postmenapozal progesteron ile T3, TSH ve beta-HCG düzeylerinin karşılaştırılmasında anlamlı farklılıklar saptanmamıştır.( p > 0.05). Ayrıca hasta grubunda PRL ve beta-HCG düzeylerinde hastalığın aktivitesine göre anlamlı farklılık saptanmadı ( p > 0.05).
..

Keywords

kanser , meme , hormon , endokrin

Ethical Statement

-

Supporting Institution

-

Project Number

-

Thanks

-

References

• 1. Backwinkel K Jackson AS : Some features of breast cancer and thyroid deficiency, Cancer : 1174 - 1176, 1964.
• 2, Boyns AR Cole EN Griffiths K et al : Plasma Prolactin in breast cancer. Europ J Cancer 9 : 99-102, 1973.
• 3. Bulbrook, RD : Endocrine aspects of breast and prostatic cancer an overiew. Cancer Surveys 5 : 435-445, 1986.
• 4. Di Renzo GF Schettini G and Preziosi P : Effects of some antineoplagtic agents on plasma levels of corticosterone, prolactin and thyroid stimulating hormone. Arch Int Pharmacodyn 230 : 324-329, 1977.
• 5. Dnistrian AM Greenberg EJ Dillon HJ et al : Chemohormonal therapy and endocrine function in breast cancer patients. Cancer 56 63-70, 1985.
• 6. Henderson BE Ross RK et al : Do regular ovulatory cycles increase breast cancer risk?. Cancer 56 1206-1208, 1985.
• 7. Henderson BE Ross RK Pike MC Casagrande JT Endogenous hormones as a major factor in human cancer, Cancer Research 42 : 3232-3239, 1982.
• 8. Hill P Chan P et al : Diet and endocrine-related cancer. Cancer 39 : 1820-1826, 1977.
• 9. Humphrey LJ and Swerdlow M : The relationship of breast disease to thyroid disease. Cancer : 1170-1173, 1964.
• 10. içli F : Kanserli hastalarda prolaktin. Ankara TIP Bülteni 10 : 77-92, 1988. Il. Jones LA Ota DM et al Bioavailability of estradiol as a marker for breast cancer risk assessment. Cancer Res 47 : 5224-5229, 1987.
• 12. Kirschner MA : The role of hormones in the etiology of human breast cancer. Cancer 39 : 2716-2726, 1971.
• 13. Korenrnan SG The endocrinology of breast cancer. Cancer 46 (4 suppl) : 874878, 1980.
• 14. Kwa HG De Jong-Bakker M Engelsman E Cleton FJ Plasma prolactin in human breast cancer. Lancet : 433-434, 1974.
• 15. L'Hermite M L'Hermite-DaIeriaux M • Prolactin and breast cancer. Eur J Can cer Clin Oncol 24 : 955-958, 1988.
• 16. Lipsett MB Hormones, medications and cancer Cancer 51 (12 suppl) : 2424-2429, 1983.
• 17. Lynch HT Harris RE et al : Endocrine profile in a patient with familial. breast cancer : a case-control study. Cancer 44 1860-1869, 1979.
• 18. Mac Mahon B Cole P and Brown J : Etiology of human breast cancer : a review. J Natl Cancer Inst 50 : 21-42, 1973.
• 19. Malarkey WB Kennedy M Allred LE Milo G : Physiological concentrations of prolactin can promote the growth of human breast tumor cells in culture. J Clin Endoc Metab 56 : 673-677, 1983.
• 20. MC Fadyen, TJ Forrest A PM et al : Circulating hormone concentrations in women with breast cancer, Lancct : 1100-1102, 1976.
• 21. Mittra T Hayward JL : Hypothalamic-pituitary-thyroid axis in breast cancer. Lancet : 885-888, 1974.
• 22. Modan B : Epidemiology of breast cancer. Israel J Med Sci 17 : 804-809, 1981.
• Murphy LJ Murphy LC et al : Modulation of lactogenic receptors by progestins in cultured human breast cancer cells. J Clin Endoc Metab 62 : 280-287, 19C6.
• 24. Murphy LJ Vrhovsek E Sutherland RL Lazarus L : Growth hormone binding to cultured human breast cancer cells. J Clin Endoc Metab 58 : 149-156, 1984.
• 25. Nagasawa H : Prolactin and human breast cancer : a review Eur J Cancer 15 •267-279, 1979.
• 26. Pike MC and Ross RK : Breast cancer. Brit Med Bull 40 : 351-354, 1984.
• 27. Rolandi E Barreca T et al : Plasma prolactin in breast cancer. Lancet 845-846, 1974.
• 28. Rose DP Pruitt BT : Plasma prolactin levels in patients with breast cancer. Cancer 48 : 2687-2791* 1981.
• 29. Rose Robert M : Psychoendocrinology. Williams Textbook of Endocrinology, seventh edition : 653-681, 1985.
• 30. Sheth NA Suraiya JN Ranadive KJ Sheth AR : Ectopic production of human chorionic gonadotrophin by human breast tumors. Br J Cancer 30 : 566-570, 1974.
• 31, Sheth NA Suraiya JN Sheth AR Ranadive KJ Jussawalla DJ : Ectopic production of human placental lactogen by human breast tumours. Cancer 39 : 1693-1699, 1977.
• 32. Smithline F Sherman L Kolodny HD : Prolactin and breast carcinoma New Eng J Med 292 : 784-791, 1975.
• 33. Stadel BV : Dietary iodine and risk of breast, endometrial and ovarian cancer Lancet 890-891, 1976.
• 34. Thomas DB : Do hormones cause breast cancer . Cancer 53 : 595-604, 1984.
• 35. Tormey DC Waalkes TP Simon RM : Biological markers in breast carcinoma, Clinical correlations with human chorionic gonadotrophin. Cancer 39 : 2391,2396, 1977.
• 36. Tormey DC Waalkes TP et al : Biological markers in breast carcinoma, incidence of abnormalities of CEA, HCG, Three polyamines and three minor nucleosides. Cancer 35 : 1095-1100, 1975.
• 37. Vorherr H : Thyroid function in benign and malignant breast disease. Eur J Cancer Clin Oncol 23 : 255-257, 1987.
• 38. Wysowski DK Comstock GW Belsing KJ Jau HL : Sex hormone levels in serum in relation to the development of breast cancer, Am J Epid 125 : 791-799, 1987.