Yıl 2019, Cilt 3 , Sayı 2, Sayfalar 42 - 51 2019-08-31

Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi
Effect Of Envıronmental Enrıchment On Depressıon-Lıke Behavıor, Cortıcal And Hıppocampal BDNF And IL-1 β In Vascular Dementıa Model

Osman Çengil [1] , Hale Sayan Özaçmak [2] , İnci Turan [3] , Veysel Haktan Özaçmak [4]


Amaç: Bu çalışma çevresel zenginleştirmenin (EE) kronik serebral hipoperfüzyonla (KSH) oluşturulan vasküler demans modelinde depresyon benzeri davranış, serebral korteks ve hipokampüsde beyin kaynaklı nörotrofik faktör (BDNF), kaspaz-1 ve IL-1β seviyeleri üzerine etkisini incelemek için tasarlanmıştır. Daha önceki çalışmalar EE’nin KSH modelinde oksidatif stres inhibisyonu ve endojen nörokoruyucu faktörlerin artırılmasını içeren yararlı etkilere sahip olduğunu göstermişlerdir. 

Gereç ve Yöntemler: KSH sıçanlarda bilateral ortak karotid arterlerin oklüzyonu ile oluşturulmuştur. Hayvanlar 3 gruba ayrılmıştır: Sham, standart kafes koşulları ve 4 hafta boyunca zenginleştirilmiş koşullara maruz bırakılan grup. Sükroz tercih testi ve zorlu yüzme testi (FST) KSH sonrası depresif davranışı değerlendirmek için kullanılmıştır. BDNF, IL-1β ve kaspaz-1 düzeylerindeki değişim incelenmiştir. 

Bulgular: KSH, hipokampüsde BDNF seviyesinde azalmaya, IL-1β ve kaspaz-1 düzeylerinde artış ile birlikte depresyon benzeri davranışa neden olmuştur.. 

Sonuç: EE serebral hipoperfüzyon durumunda inflamatuar yanıtı azaltarak ve BDNF seviyelerini koruyarak depresif davranışı iyileştirmede farmakolojik olmayan yeni bir strateji olabilir.

 Aim: This study was designed to investigate the effects of environmental enrichment (EE) on depressive like-behaviour, and cerebral cortex and hippocampus brain derived neurotrophic factor (BDNF), IL-1β and caspase-1 levels in vascular dementia model induced by chronic cerebral hypoperfusion (CCH). Previous studies demonstrated that EE posesses beneficial effects againts CCH including inhibition oxidative stress and stimulation of endogenous neuroprotective factors. 

Material and Methods: CCH was induced by permanent occlusion of the bilateral common carotid arteries in rats. Animals were divided into three groups: Sham control, standart cage condition and enriched condition for 4 weeks. Sucrose preference and forced swiming test (FST) were used for evaluation of depressive like behaviour after induction of CCH.   The change in BDNF, IL-1β and caspase-1 levels were also examined. 

Results: CCH caused a decrease in the hippocampus BDNF level and depressive behaviour associated with increase in IL-1β and caspase-1 levels. EE attenuated depressive behaviour by preserving BDNF level and reducing inflammatory response in hippocampus. 

Conclusion: In conclusion, EE may be a new non-pharmacological strategy for ameliorating depressive like behaviour through reducing inflammatory response and restore BDNF levels in cerebral hypoperfusion condition.

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Birincil Dil tr
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0002-0702-6751
Yazar: Osman Çengil

Orcid: 0000-0002-3564-0468
Yazar: Hale Sayan Özaçmak (Sorumlu Yazar)
Ülke: Turkey


Orcid: 0000-0003-2211-3914
Yazar: İnci Turan

Orcid: 0000-0003-2651-8353
Yazar: Veysel Haktan Özaçmak

Destekleyen Kurum Zonguldak Bülent Ecevit Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü
Proje Numarası 2016-26259946-01
Tarihler

Yayımlanma Tarihi : 31 Ağustos 2019

Bibtex @araştırma makalesi { baktipd594521, journal = {Batı Karadeniz Tıp Dergisi}, issn = {}, eissn = {2587-0602}, address = {Bülent Ecevit Üniversitesi Tıp Fakültesi Dekanlığı İbn-i Sina Kampüsü 67600 Esenköy/Kozlu ZONGULDAK}, publisher = {Bülent Ecevit Üniversitesi}, year = {2019}, volume = {3}, pages = {42 - 51}, doi = {}, title = {Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi}, key = {cite}, author = {Çengil, Osman and Sayan Özaçmak, Hale and Turan, İnci and Özaçmak, Veysel Haktan} }
APA Çengil, O , Sayan Özaçmak, H , Turan, İ , Özaçmak, V . (2019). Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi. Batı Karadeniz Tıp Dergisi , 3 (2) , 42-51 . Retrieved from https://dergipark.org.tr/tr/pub/baktipd/issue/48419/594521
MLA Çengil, O , Sayan Özaçmak, H , Turan, İ , Özaçmak, V . "Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi". Batı Karadeniz Tıp Dergisi 3 (2019 ): 42-51 <https://dergipark.org.tr/tr/pub/baktipd/issue/48419/594521>
Chicago Çengil, O , Sayan Özaçmak, H , Turan, İ , Özaçmak, V . "Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi". Batı Karadeniz Tıp Dergisi 3 (2019 ): 42-51
RIS TY - JOUR T1 - Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi AU - Osman Çengil , Hale Sayan Özaçmak , İnci Turan , Veysel Haktan Özaçmak Y1 - 2019 PY - 2019 N1 - DO - T2 - Batı Karadeniz Tıp Dergisi JF - Journal JO - JOR SP - 42 EP - 51 VL - 3 IS - 2 SN - -2587-0602 M3 - UR - Y2 - 2019 ER -
EndNote %0 Batı Karadeniz Tıp Dergisi Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi %A Osman Çengil , Hale Sayan Özaçmak , İnci Turan , Veysel Haktan Özaçmak %T Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi %D 2019 %J Batı Karadeniz Tıp Dergisi %P -2587-0602 %V 3 %N 2 %R %U
ISNAD Çengil, Osman , Sayan Özaçmak, Hale , Turan, İnci , Özaçmak, Veysel Haktan . "Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi". Batı Karadeniz Tıp Dergisi 3 / 2 (Ağustos 2019): 42-51 .
AMA Çengil O , Sayan Özaçmak H , Turan İ , Özaçmak V . Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi. Batı Karadeniz Tıp Dergisi. 2019; 3(2): 42-51.
Vancouver Çengil O , Sayan Özaçmak H , Turan İ , Özaçmak V . Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi. Batı Karadeniz Tıp Dergisi. 2019; 3(2): 51-42.