The effect of the cross-linker ratio used in gellan gum biomaterial synthesis on biomineralization
Year 2021,
, 27 - 31, 31.12.2021
Serbülent Türk
,
Burak Ünlü
,
Mahmut Özacar
Abstract
The first step in using polymeric materials for many applications is their crosslinking. Before application, the cross-linker used in crosslinking should be kept at an optimum ratio. The use of gellan gum, a polymeric material, as an intra-body biomaterial is also included in these application areas. In this study, the effect of CaCl2 ratio used as GG cross-linker on the biomineralization of the obtained GG hydrogel was investigated. FTIR, XRD, SEM and EDS analyzes of the synthesized and lyophilized cross-linked GG samples were performed before and after biomineralization. In line with the results obtained, it was observed that the bioactivity of the GG hydrogel could be changed by changing the cross-linking ratio.
Supporting Institution
Sakarya Üniversitesi
Project Number
2019-6-23-223
Thanks
This work was supported by the Scientific Research Projects Commission of Sakarya University (Project number: 2019-6-23-223).
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Year 2021,
, 27 - 31, 31.12.2021
Serbülent Türk
,
Burak Ünlü
,
Mahmut Özacar
Project Number
2019-6-23-223
References
- Bendtsen, S. T., & Wei, M. (2015). Synthesis and characterization of a novel injectable alginate-collagen-hydroxyapatite hydrogel for bone tissue regeneration. Journal of Materials Chemistry B, 3(15), 3081–3090. https://doi.org/10.1039/c5tb00072f
- Choi, Y., Kim, H.-J., & Min, K.-S. (2016). Effects of proanthocyanidin, a crosslinking agent, on physical and biological properties of collagen hydrogel scaffold. Restorative Dentistry & Endodontics, 41(4), 296. https://doi.org/10.5395/rde.2016.41.4.296
- Costa, L., Silva-correia, J., & Oliveira, J. M. (2018). Gellan Gum-Based Hydrogels for Osteochondral Repair. In S. R. J. Oliveira J., Pina S., Reis R. (Ed.), Osteochondral Tissue Engineering (pp. 281–304). https://doi.org/10.1007/978-3-319-76711-6
- Hua, J., Li, Z., Xia, W., Yang, N., Gong, J., Zhang, J., & Qiao, C. (2016). Preparation and properties of EDC/NHS mediated crosslinking poly (gamma-glutamic acid)/epsilon-polylysine hydrogels. Materials Science and Engineering C, 61, 879–892. https://doi.org/10.1016/j.msec.2016.01.001
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- Ye, B., Zhang, S., Li, R., Li, L., Lu, L., & Zhou, C. (2018). An in-situ formable and fi brils-reinforced polysaccharide composite hydrogel by self-crosslinking with dual healing ability, 156, 238–246. https://doi.org/10.1016/j.compscitech.2017.12.032