The effect of the cross-linker ratio used in gellan gum biomaterial synthesis on biomineralization
Yıl 2021,
, 27 - 31, 31.12.2021
Serbülent Türk
,
Burak Ünlü
,
Mahmut Özacar
Öz
The first step in using polymeric materials for many applications is their crosslinking. Before application, the cross-linker used in crosslinking should be kept at an optimum ratio. The use of gellan gum, a polymeric material, as an intra-body biomaterial is also included in these application areas. In this study, the effect of CaCl2 ratio used as GG cross-linker on the biomineralization of the obtained GG hydrogel was investigated. FTIR, XRD, SEM and EDS analyzes of the synthesized and lyophilized cross-linked GG samples were performed before and after biomineralization. In line with the results obtained, it was observed that the bioactivity of the GG hydrogel could be changed by changing the cross-linking ratio.
Destekleyen Kurum
Sakarya Üniversitesi
Proje Numarası
2019-6-23-223
Teşekkür
This work was supported by the Scientific Research Projects Commission of Sakarya University (Project number: 2019-6-23-223).
Kaynakça
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Yıl 2021,
, 27 - 31, 31.12.2021
Serbülent Türk
,
Burak Ünlü
,
Mahmut Özacar
Proje Numarası
2019-6-23-223
Kaynakça
- Bendtsen, S. T., & Wei, M. (2015). Synthesis and characterization of a novel injectable alginate-collagen-hydroxyapatite hydrogel for bone tissue regeneration. Journal of Materials Chemistry B, 3(15), 3081–3090. https://doi.org/10.1039/c5tb00072f
- Choi, Y., Kim, H.-J., & Min, K.-S. (2016). Effects of proanthocyanidin, a crosslinking agent, on physical and biological properties of collagen hydrogel scaffold. Restorative Dentistry & Endodontics, 41(4), 296. https://doi.org/10.5395/rde.2016.41.4.296
- Costa, L., Silva-correia, J., & Oliveira, J. M. (2018). Gellan Gum-Based Hydrogels for Osteochondral Repair. In S. R. J. Oliveira J., Pina S., Reis R. (Ed.), Osteochondral Tissue Engineering (pp. 281–304). https://doi.org/10.1007/978-3-319-76711-6
- Hua, J., Li, Z., Xia, W., Yang, N., Gong, J., Zhang, J., & Qiao, C. (2016). Preparation and properties of EDC/NHS mediated crosslinking poly (gamma-glutamic acid)/epsilon-polylysine hydrogels. Materials Science and Engineering C, 61, 879–892. https://doi.org/10.1016/j.msec.2016.01.001
- Kokubo, T., & Takadama, H. (2006). How useful is SBF in predicting in vivo bone bioactivity? Biomaterials, 27(15), 2907–2915. https://doi.org/10.1016/j.biomaterials.2006.01.017
- Maiti, S., Khillar, P. S., Mishra, D., Nambiraj, N. A., & Jaiswal, A. K. (2021). Physical and self – crosslinking mechanism and characterization of chitosan-gelatin-oxidized guar gum hydrogel. Polymer Testing, 97, 107155. https://doi.org/10.1016/j.polymertesting.2021.107155
- Tang, G., Tan, Z., Zeng, W., Wang, X., Shi, C., Liu, Y., … Ye, X. (2020). Recent Advances of Chitosan-Based Injectable Hydrogels for Bone and Dental Tissue Regeneration. Frontiers in Bioengineering and Biotechnology, 8(September), 1–15. https://doi.org/10.3389/fbioe.2020.587658
- Xue, J., Feng, C., Xia, L., Zhai, D., Ma, B., Wang, X., … Wu, C. (2018). Assembly Preparation of Multilayered Biomaterials with High Mechanical Strength and Bone-Forming Bioactivity. Chemistry of Materials, 30(14), 4646–4657. https://doi.org/10.1021/acs.chemmater.8b01272
- Ye, B., Zhang, S., Li, R., Li, L., Lu, L., & Zhou, C. (2018). An in-situ formable and fi brils-reinforced polysaccharide composite hydrogel by self-crosslinking with dual healing ability, 156, 238–246. https://doi.org/10.1016/j.compscitech.2017.12.032